A5040648061- Advanced biosensing and bioanalysis techniques
- Insect symbiosis and bacterial influences
- Natural product bioactivities and synthesis
- Extracellular vesicles in disease
- Hippo pathway signaling and YAP/TAZ
- Invertebrate Immune Response Mechanisms
- Biosensors and Analytical Detection
- Epigenetics and DNA Methylation
- Insect Resistance and Genetics
- Advanced Nanomaterials in Catalysis
- Sesquiterpenes and Asteraceae Studies
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Cancer-related gene regulation
- Phytochemical compounds biological activities
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Mosquito-borne diseases and control
- Ginseng Biological Effects and Applications
- Cancer-related molecular mechanisms research
- Plant-Microbe Interactions and Immunity
- Marine Sponges and Natural Products
- RNA Research and Splicing
- Insect and Pesticide Research
- MXene and MAX Phase Materials
Shanghai First Maternity and Infant Hospital
2020-2025
University of Chinese Academy of Sciences
2022-2025
Shanghai Institute of Pharmaceutical Industry
2023-2025
Kunming Institute of Botany
2023-2025
Wuhan University
2020-2025
State Key Laboratory of Virology
2023-2025
Wuhan Institute of Virology
2023-2025
Henan University
2025
Xi'an Honghui Hospital
2023-2025
Xi'an Jiaotong University
2023-2025
Abstract Endometrial cancer stem cells (ECSCs) are stem-like endowed with self-renewal and differentiation abilities, these essential for progression in endometrial (EC). As hallmarks of the tumour microenvironment (TME), hypoxia hypoxia-inducing factors (HIFs) give rise to dysregulation stemness genes, such as SOX2. Against this backdrop, we investigated regulatory mechanisms regulated by HIFs SOX2 ECSCs during EC development. Here, isolated from cell lines tissues were found express genes...
Mitochondrial quality control plays an important role in maintaining mitochondrial homeostasis and function. Disruption of degrades brain We found that flunarizine (FNZ), a drug whose chronic use causes parkinsonism, led to parkinsonism-like motor dysfunction mice. FNZ induced decreased mass specifically the brain. content both neurons astrocytes, without affecting number nigral dopaminergic neurons. In human neural progenitor cells, also depletion. Mechanistically, independent ATG5- or...
Chronic hepatitis B virus (HBV) infection can significantly increase the incidence of cirrhosis and liver cancer, there is no curative treatment. The persistence HBV covalently closed circular DNA (cccDNA) major obstacle antiviral treatments. cccDNA formed through repairing viral partially double-stranded relaxed (rcDNA) by varies host factors. However, detailed mechanisms are not well characterized. To dissect biogenesis cccDNA, we took advantage an in vitro rcDNA repair system to...
Peptidoglycan recognition proteins (PGRPs) and commensal microbes mediate pathogen infection outcomes in insect disease vectors. Although PGRP-LD is retained multiple vectors, its role host defense remains elusive. Here we report that Anopheles stephensi protects the vector from malaria parasite by regulating gut homeostasis. Specifically, knock down of (dsLD) increased susceptibility to Plasmodium berghei infection, decreased abundance microbiota changed their spatial distribution. This...
Objective: Severe acute pancreatitis (SAP) can lead to lung injury (ALI). This study investigated the therapeutic effect of emodin and its molecular mechanisms in a rat model SAP-ALI. Methods: Forty male Sprague-Dawley rats were randomly divided into groups: Control (CON), SAP (SAP), (EMO), C23 (C23). The latter three groups induced for SAP-ALI by retrograde injection 5% sodium taurocholate biliary-pancreatic duct treated with vehicle, or C23, respectively. One day post induction, their...
Hepatitis B virus (HBV) chronically infects 296 million individuals and there is no cure. As an important step of viral life cycle, the mechanisms HBV egress remain poorly elucidated. With proteomic approach to identify capsid protein (HBc) associated host factors siRNA screen, we uncovered tumor susceptibility gene 101 (TSG101). Knockdown TSG101 in HBV-producing cells, HBV-infected cells transgenic mice suppressed release. Co-immunoprecipitation site mutagenesis revealed that VFND motif...
Hepatitis B virus (HBV) chronically infects 296 million people worldwide, posing a major global health threat. Export of HBV RNAs from the nucleus to cytoplasm is indispensable for viral protein translation and genome replication, however mechanisms regulating this critical process remain largely elusive. Here, we identify key host factor embryonic lethal, abnormal vision, Drosophila-like 1 (ELAVL1) that binds controls their nuclear export. Using an unbiased quantitative proteomics screen,...
Abstract In the field of biomedical research, organoids represent a remarkable advancement that has potential to revolutionize our approach studying human diseases even before clinical trials. Organoids are essentially miniature 3D models specific organs or tissues, enabling scientists investigate causes diseases, test new drugs, and explore personalized medicine within controlled laboratory setting. Over past decade, organoid technology made substantial progress, allowing researchers create...
LATS1/2 are frequently mutated and down-regulated in endometrial cancer (EC), but the contributions of EC progression remains unclear. Impaired antigen presentation due to mutations or downregulation major histocompatibility complex class I (MHC-I) has been implicated tumor immune evasion. Herein, we elucidate oncogenic role that dysregulation leads evasion through down-regulation MHC-I. The mutation expression as well clinical significance was assessed TCGA cohort our sample cohort....
Ischemic stroke remains the leading cause of death worldwide, and in experimental studies ischemic stroke, neuroprotective agents may display good efficacy. In our previous work, Fenazinel showed promising effects entered phase I clinical trials China. However, some side have limited its further study. To explore novel with higher potency lower cardiotoxicity, this a series derivatives piperidine urea groups (A1–A13) were designed synthesized. The effect A1–A13 was evaluated human...
ABSTRACT Background Previous studies have suggested that hypoxia‐inducible factor 1‐α (HIF‐1α) exerted multiple effects on different central nervous system disorders. However, it is still uncertain whether plasma HIF‐1α can be a causal indicator for the relevant diseases. This study aimed to test causality relationship between and neurological diseases, including cerebrovascular migraines, neurodegenerative diseases with Mendelian randomization (MR) method. Methods Single‐nucleotide...
To explore the genetic alterations, pathobiological functions, and downstream molecular mediators of RBM10 in endometrial cancer (EC) cells. Targeted sequencing The Cancer Genome Atlas (TCGA) dataset analysis were performed. Following knockout (KO) or exogenous overexpression EC cell lines, biological functions underlying mechanism cells evaluated by Western blot, qRT-PCR, CCK-8, Transwell, RNA-sequencing (RNA-seq), Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analysis....
ABSTRACT Controlled photocatalytic conversion of CO 2 into premium fuel such as methane (CH 4 ) offers a sustainable pathway towards carbon energy cycle. However, the efficiency and selectivity are still unsatisfactory due to limited availability active sites on current photocatalysts. To resolve this issue, design oxygen vacancies (OVs) in metal–oxide semiconductors is an effective option. Herein, situ deposition TiO onto SiO nanospheres construct @TiO core–shell structure was performed...
Orthopedic wound infection is a difficult problem in the clinic. Accurate and rapid microbiological test results are essential for case management, antibiotic therapy, control. We retrospectively evaluated 1285 specimens (puncture fluid, catheter, secretions, joint lavage extraction blood culture, drainage cerebrospinal bone, prosthesis tissue, etc.) from 739 patients who received orthopedic diagnosis treatment, using routine conventional method (RCM)s as reference to evaluate performance of...