A5000644083- Muscle Physiology and Disorders
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Seaweed-derived Bioactive Compounds
- Glycosylation and Glycoproteins Research
- Infant Nutrition and Health
- Reproductive Biology and Fertility
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- Effects of Radiation Exposure
- Cancer, Hypoxia, and Metabolism
- Sperm and Testicular Function
- Ruminant Nutrition and Digestive Physiology
- Radiopharmaceutical Chemistry and Applications
- Plant Disease Resistance and Genetics
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Phytochemical and Pharmacological Studies
- Plant Pathogens and Resistance
- Muscle metabolism and nutrition
- Animal Genetics and Reproduction
- Neurogenetic and Muscular Disorders Research
- Animal Nutrition and Physiology
China Agricultural University
2016-2025
Hebei Agricultural University
2024
Xuzhou Medical College
2023
BOE Technology Group (China)
2022
Guangdong Medical College
2007-2021
Northwestern Polytechnical University
2021
Ministry of Industry and Information Technology
2021
First Affiliated Hospital of Anhui Medical University
2018
Anhui Medical University
2018
Fourth People’s Hospital of Jinan
2013-2016
MicroRNA-mediated post-transcriptional regulation plays key roles in stem cell self-renewal and tumorigenesis. However, the vivo functions of specific microRNAs controlling mammary (MaSC) activity breast cancer formation remain poorly understood. Here we show that miR-31 is highly expressed MaSC-enriched basal population tumors, regulated by NF-κB signaling. We demonstrate promotes epithelial proliferation MaSC expansion at expense differentiation vivo. Loss compromises tumor growth, reduces...
Lacking of treatment methods for the patients with triple negative breast cancer (TNBC) underscores pivotal needs to further understand its biology as well find better biomarkers and develop novel therapeutic strategies. Increasing evidences support that aberrantly expressed microRNAs (miRNAs) are involved in tumorigenesis may serve diagnostic prognostic purposes various cancers. In current study, we found miR-455-3p miR-196a-5p were intensively overexpressed TNBC compared hormone receptor...
Abstract Satellite cells are crucial for skeletal muscle regeneration, but the molecular mechanisms regulating satellite not entirely understood. Here, we show that immunoglobulin superfamily containing leucine-rich repeat (Islr), a newly identified marker mesenchymal stem cells, stabilizes canonical Wnt signaling and promote regeneration. Loss of Islr delays regeneration in adult mice. In absence Islr, myoblasts fail to develop into mature myotubes due defective differentiation. interacts...
Muscle regeneration is a complex process relying on precise teamwork between multiple cell types, including muscle stem cells (MuSCs) and fibroadipogenic progenitors (FAPs). FAPs are also the main source of intramuscular adipose tissue (IMAT). Muscles without exhibit decreased IMAT infiltration but deficient regeneration, indicating importance in repair process. Here, we demonstrate presence bidirectional crosstalk MuSCs via their secretion extracellular vesicles (EVs) containing distinct...
Genesis of novel gene regulatory modules is largely responsible for morphological and functional evolution. De novo generation cis-regulatory elements (CREs) much rarer than genomic events that alter existing CREs such as transposition, promoter switching or co-option. Only one case de has been reported to date, in fish without involvement phenotype alteration. Yet, this event likely occurs other animals helps drive genetic/phenotypic variation. Using a porcine model spontaneous hearing loss...
Hair follicles (HF) undergo precisely regulated recurrent cycles of growth, cessation, and rest. The transitions from anagen (growth), to catagen (regression), telogen (rest) involve a physiological involution the HF. This process is likely coordinated by variety mechanisms including apoptosis loss growth factor signaling. However, precise molecular underlying follicle after hair keratinocyte differentiation shaft assembly remain poorly understood. Here we demonstrate that highly conserved...
The p53 tumor suppressor gene is mutated or deleted in nearly half of human cancers. murine double minute 2 (Mdm2) and Mdmx represent two important cellular regulators p53. aim this study was to evaluate the abnormalities p53, Mdm2 genes archived breast We assessed genetic instability at using high resolution multi-color fluorescent situ hybridization (FISH) protocol detected expression status protein (TP53), MDMx MDM2 by immunohistochemistry 115 samples infiltrating ductal carcinomas with...
The present study aimed to investigate the effect of melatonin (MT) supplementation on in vitro maturation vitrified mouse germinal vesicle (GV) oocytes. fresh oocytes were randomly divided into three groups: untreated (control), or by open-pulled straw method without (vitrification group) with MT + group). After warming, cultured vitro, then reactive oxygen species (ROS) and glutathione (GSH) levels, mitochondrial membrane potential, ATP spindle morphology, mRNA expression assembly...
Hair follicle stem cells (HFSCs) and subsequent generations of matrix progeny make lineage choices by responding to spatiotemporal signals; however, the cues driving that specification are not well understood. Here, we demonstrate dynamics microRNA (miR)-29 expression inversely proportional HFSC progression. Furthermore, show sustained miR-29a/b1 overexpression in anagen or telogen mice causes a short-hair phenotype eventual hair loss inhibiting proliferation HFSCs likely preventing their...
Aims To identify and characterize a bacterial strain BAC03, evaluate its biological control activity against potato common scab (Streptomyces spp.) an antimicrobial substance produced by BAC03. Methods Results Bacterial isolated from suppressive soil, was identified as Bacillus amyloliquefaciens analysing sequences of fragments the recA, recN, cheA gyrA genes. BAC03 displayed antagonistic Streptomyces spp. on agar plates using co-culture method. In glasshouse assays, applied in potting mix...
miRNAs are increasingly being implicated as key regulators of cell proliferation, apoptosis, and differentiation. miRNA-34c appears to play a crucial role in cancer pathogenesis wherein it exerts its effect tumor suppressor. However, the miR-34c myoblast proliferation remains poorly understood. Here, we found that overexpression inhibited myoblasts by reducing protein mRNA expression cycle genes. In contrast, blocking function promoted increased Moreover, directly targeted YY1 expression....
Plant polysaccharides are important for anti-aging research. Polysaccharides from Hemerocallis citrina Baroni (H. citrina) have been reported to antioxidant activity; however, their roles and mechanisms not clear. In this study, we extracted H. by an ultrasonic-assisted water extraction–alcohol precipitation method chemically determined the physicochemical properties such as extraction yield, content, in vitro of polysaccharide-rich extract (HCPRE). Using Caenorhabditis elegans (C. elegans)...
IgY(ΔFc), containing only CH1 and CH2 domains, is expressed in the serum of some birds reptiles, such as ducks turtles. The duck IgY(ΔFc) produced by same υ gene that expresses intact IgY form (CH1-4) using different transcriptional termination sites. In this study, we show are encoded distinct genes red-eared turtle (Trachemys scripta elegans). At least eight five transcripts were found a single turtle. Together with Southern blotting, our data suggest multiple encoding both forms present...
This study was conducted to investigate the effect of vitrification on dynamics global transcriptome in bovine germinal vesicle (GV) oocytes and their vitro-derived metaphase II (MII) oocytes. The GV were vitrified using open-pulled straw method. After warming, resulting MII-stage cultured vitro for 2 h 24 respectively then collected. fresh MII used as controls. Then, each pool (fresh GV, n = 3; 4; MII, 1 derived from 2) different stages mRNA sequencing. results showed that maturation rates...
Female reproductive (ovarian) aging is distinctively characterized by a markedly reduced function due to remarkable decline in quality and quantity of follicles oocytes. Selenium (Se) has been implicated playing many important biological roles male fertility reproduction; however, its potential female reproduction, particularly subjects, remain poorly elucidated. Therefore, the current study we used murine model elucidated how different Se-levels might affect efficiency females. Our results...
Background: Brown adipose tissue (BAT) dissipates chemical energy as heat and has the potential to be a protective strategy prevent obesity. microRNAs (miRNAs) are emerging important posttranscriptional factors affecting thermogenic function of BAT. However, regulatory mechanism underlying miRNA-mediated metabolism in BAT is not fully understood. Here, we explored roles miR-22 thermogenesis metabolism. Methods: Using global conditional knockout mice vivo models primary brown adipocytes an...
Abstract Background This study investigated the effect of melatonin (MT) on cell cycle (G1/S/G2/M) parthenogenetic zygotes developed from vitrified-warmed mouse metaphase II (MII) oocytes and elucidated potential mechanism MT action in first cleavage embryos. Results After vitrification warming, were parthenogenetically activated (PA) vitro cultured (IVC). Then spindle morphology chromosome segregation oocytes, maternal mRNA levels genes including Miss, Doc1r, Setd2 Ythdf2 pronuclear...