A5006504701- T-cell and B-cell Immunology
- Phytoplasmas and Hemiptera pathogens
- Glycosylation and Glycoproteins Research
- Livestock and Poultry Management
- Monoclonal and Polyclonal Antibodies Research
- Aquaculture disease management and microbiota
- Animal Nutrition and Physiology
- RNA modifications and cancer
- melanin and skin pigmentation
- Plant Pathogenic Bacteria Studies
- Animal Genetics and Reproduction
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cocoa and Sweet Potato Agronomy
- Invertebrate Immune Response Mechanisms
- Congenital heart defects research
- Immune Response and Inflammation
- RNA and protein synthesis mechanisms
- Plant-Microbe Interactions and Immunity
- Congenital Heart Disease Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Microbial bioremediation and biosurfactants
- Genetic and Kidney Cyst Diseases
- Selenium in Biological Systems
China Agricultural University
2009-2023
Uppsala University
2019-2023
University of Florida
2014-2022
Shenzhen University
2020
National Institutes for Food and Drug Control
2019
Tianjin Medical University General Hospital
2017
Columbus Oncology and Hematology Associates
2016
University of Minnesota
2007-2015
Indian River State College
2013-2014
Shanghai Jiao Tong University
2014
Citrus huanglongbing (HLB), caused by three species of fastidious, phloem-limited 'Candidatus Liberibacter', is one the most destructive diseases citrus worldwide. To date, there no established cure for this century-old and yet, newly emerging disease. As a potential control strategy HLB, 31 antibiotics were screened effectiveness phytotoxicity using optimized graft-based screening system with Liberibacter asiaticus' (Las)-infected scions. Actidione Oxytetracycline phytotoxic to less than...
Genesis of novel gene regulatory modules is largely responsible for morphological and functional evolution. De novo generation cis-regulatory elements (CREs) much rarer than genomic events that alter existing CREs such as transposition, promoter switching or co-option. Only one case de has been reported to date, in fish without involvement phenotype alteration. Yet, this event likely occurs other animals helps drive genetic/phenotypic variation. Using a porcine model spontaneous hearing loss...
Huanglongbing (HLB) is the most devastating disease of citrus. The global citrus industry in urgent need effective chemical treatments for HLB control because its rapid spreading worldwide. Due to fastidious nature pathogens, and poor permissibility leaf surfaces, screening chemicals can be challenging. In this study, we developed a graft-based chemotherapy method rapidly screen potential HLB-controlling compounds. addition, improved transmission efficiency by using best HLB-affected...
Muffs and beard (Mb) is a phenotype in chickens where groups of elongated feathers gather from both sides the face (muffs) below beak (beard). It an autosomal, incomplete dominant encoded by locus. Here we use genome-wide association (GWA) analysis, linkage Identity-by-Descent (IBD) mapping, array-CGH, genome re-sequencing expression analysis to show that Mb allele causing derived complex structural variation (SV) on GGA27 leads altered gene HOXB8. This was shown be completely associated...
Abstract Background Huanglongbing (HLB) is a worldwide devastating disease of citrus. There are no effective control measures for this newly emerging but century-old disease. Previously, we reported combination Penicillin G and Streptomycin was in eliminating or suppressing the associated bacterium, ‘ Candidatus Liberibacter asiaticus’ (Las). Results Here report bacterial composition community structure HLB-affected citrus plants during growing season while being treated with antibiotic...
Here, we have evaluated the general genomic structure and diversity studied divergence resulting from selection historical admixture events for a collection of worldwide chicken breeds. In total, 636 genomes (43 populations) were sequenced chickens American, Chinese, Indonesian, European origin. Evaluated populations included wild junglefowl, rural indigenous chickens, breeds that been widely used to improve modern western poultry current commercial stocks bred efficient meat egg production....
IgY(ΔFc), containing only CH1 and CH2 domains, is expressed in the serum of some birds reptiles, such as ducks turtles. The duck IgY(ΔFc) produced by same υ gene that expresses intact IgY form (CH1-4) using different transcriptional termination sites. In this study, we show are encoded distinct genes red-eared turtle (Trachemys scripta elegans). At least eight five transcripts were found a single turtle. Together with Southern blotting, our data suggest multiple encoding both forms present...
Abstract Although evolutionarily just as ancient IgM, it has been thought for many years that IgD is not present in birds. Based on the recently sequenced genomes of 48 bird species well high-throughput transcriptome sequencing immune-related tissues, we demonstrate this work ostrich (Struthio camelus) possesses a functional δ gene encodes membrane-bound H chain with seven CH domains. Furthermore, sequences were clearly identified other species, demonstrating widely distributed among birds...
Previous studies on the immunoglobulin (Ig) genes in avian species are limited (mainly to galliformes and anseriformes) but have revealed several interesting features, including absence of IgD Igκ encoding genes, inversion IgA gene use conversion as primary mechanism generate an antibody repertoire. To better understand Ig their evolutionary development birds, we analyzed ostrich (Struthio camelus), which is one most primitive birds. Similar chicken duck, expressed only three IgH chain...
PKD1 and PKD2 mutations could lead to autosomal dominant polycystic kidney disease (ADPKD), which afflicts millions of people worldwide.Due the marked differences in lifespan, size, anatomy, physiology from humans, rodent ADPKD models cannot fully mimic disease.To obtain a large animal model that recapitulates disease, we constructed mini-pig by mono-allelic knockout (KO) using zinc finger nuclease.The KO pigs had lower expression than their wild-type littermates at both transcriptional...
Huanglongbing (HLB)-affected citrus often display zinc deficiency symptoms. In this study, supplemental was applied to determine its effect on Candidatus Liberibacter asiaticus (Las) titre, HLB symptoms, and leaf microbiome.HLB-affected were treated with various amounts of zinc. The treatments promoted Las growth affected microbiomes in leaves. Phylochip(™) -based results indicated that 5475 over 50 000 known Operational Taxonomic Units (OTUs) 52 phyla detected the midribs HLB-affected...
The purpose of this study was to examine histological alterations on osteoblasts from the alveolar bone transgenic mice with targeted ablation osteoctyes. Eighteen weeks-old based diphtheria toxin (DT) receptor-mediated cell knockout (TRECK) system were used in these experiments. Mice injected intraperitoneally 50 µg/kg DT PBS, or only PBS as control. Two weeks after injections, subjected transcardiac perfusion 4% paraformaldehyde 0.1M phosphate buffer (pH 7.4), and available removed for...
Abstract Mammalian IgG and IgE are thought to have evolved from IgY of nonmammalian tetrapods; however, no diversification subclasses has been reported in reptiles or birds, which phylogenetically close mammals. To our knowledge, we report the first evidence presence multiple IgY-encoding (υ) genes snakes. Two υ were identified snake Elaphe taeniura, three Burmese python (Python molurus bivittatus). Although four displayed a conventional four-H chain C region exon structure, one lacked H 2...
Crossing of populations has been, and still is, a central component in domestication breed variety formation. It is way for breeders to utilize heterosis introduce new genetic variation into existing plant livestock populations. During the mid-19th century, several chicken breeds that had been introduced America from Europe Asia became founders those formed USA. Historical records about genealogy these are often unclear inconsistent. Here, we used genomics an attempt describe ancestry White...
We compared the genomes of multiple domestic chicken breeds with red and white earlobes to identify differentiated regions between groups differing in earlobe color. This was done using a selective sweep mapping approach based on whole-genome sequence data. The most significant identified chromosome 11, where originated from Mediterranean share common haplotype, candidate genes are located. plausible functional gene is Melanocortin 1 Receptor (MC1R), receptor known regulate pigmentation skin...
Abstract Rumpless chickens exhibit an abnormality in their tail development. The genetics and biology of this trait has been studied for decades to illustrate a broad variation both the types inheritance severity developmental defects tail. In study, we created backcross pedigree by intercrossing Piao (rumpless) with Xianju (normal) investigate genetic mechanisms molecular basis rumpless chicken. Through genome-wide association linkage analyses, candidate region was fine-mapped 798.5 kb...