A5066502756- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- High Altitude and Hypoxia
- Livestock and Poultry Management
- RNA modifications and cancer
- Animal Nutrition and Physiology
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Genetic diversity and population structure
- Adipose Tissue and Metabolism
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Physiological and biochemical adaptations
- melanin and skin pigmentation
- interferon and immune responses
- Genomics and Chromatin Dynamics
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Olfactory and Sensory Function Studies
- Antimicrobial Peptides and Activities
- Bat Biology and Ecology Studies
Inner Mongolia Agricultural University
2024
Annoroad Gene Technology (China)
2021
Sichuan Agricultural University
2014-2019
Uncovering genetic variation through resequencing is limited by the fact that only sequences with similarity to reference genome are examined. Reference genomes often incomplete and cannot represent full range of diversity as a result geographical divergence independent demographic events. To more comprehensively characterize pigs ( Sus scrofa ), we generated de novo assemblies nine geographically phenotypically representative from Eurasia. By comparing them pig assembly, uncovered...
Abstract Background Species living at high altitude are subject to strong selective pressures due inhospitable environments (e.g., hypoxia, low temperature, solar radiation, and lack of biological production), making these species valuable models for comparative analyses local adaptation. Studies that have examined high-altitude adaptation identified a vast array rapidly evolving genes characterize the dramatic phenotypic changes in animals. However, how environment shapes gene expression...
Genesis of novel gene regulatory modules is largely responsible for morphological and functional evolution. De novo generation cis-regulatory elements (CREs) much rarer than genomic events that alter existing CREs such as transposition, promoter switching or co-option. Only one case de has been reported to date, in fish without involvement phenotype alteration. Yet, this event likely occurs other animals helps drive genetic/phenotypic variation. Using a porcine model spontaneous hearing loss...
Abstract Background: Since the domestication of red jungle fowls (Gallus gallus; dating back to ~10 000 B.P.) in Asia, domestic chickens gallus domesticus) have been subjected combined effects natural selection and human-driven artificial selection; this has resulted marked phenotypic diversity a number traits, including behavior, body composition, egg production, skin color. Population genomic variations through diversifying not fully investigated. Findings: The whole genomes 78 were...
There are hundreds of phenotypically distinguishable domestic chicken breeds or lines with highly specialized traits worldwide, which provide a unique opportunity to illustrate how selection shapes patterns genetic variation. many local in China.Here, we population genome landscape variations 86 chickens representing 10 diverse breeds. Genome-wide analysis indicated that sex chromosomes have less diversity and under stronger than autosomes during domestication adaptation. We found an...
N6-methyladenosine (m6A) is a ubiquitous reversible epigenetic RNA modification that plays an important role in the regulation of post-transcriptional protein coding gene expression. Liver vital organ and major metabolism with numerous functions. Information concerning dynamic patterns mRNA m6A methylation during postnatal development liver has been long overdue elucidation this information will benefit for further deciphering multitude functional outcomes methylation. Here, we profile...
The transcriptional profiles of mammals during brain development and ageing have been characterized. However the global expression patterns transcriptome in chicken not explored. Here, we systematically investigated temporal lncRNAs mRNAs across 8 stages (including 3 embryonic stages, 2 growth adult stages) female cerebrum. We identified 39,907 putative 14,558 mRNAs, by tracking a set age-dependent genes predicted potential biological functions based on co-expression network. results showed...
The recently developed high-throughput chromatin conformation capture (Hi-C) technology enables us to explore the spatial architecture of genomes, which is increasingly considered an important regulator gene expression.To investigate changes in three-dimensional (3D) structure and its mediated expression during adipogenesis myogenesis, we comprehensively mapped 3D organization for four cell types (3T3-L1 pre-adipocytes, 3T3-L1-D adipocytes, C2C12 myoblasts, C2C12-D myotubes).We demonstrate...
Parentage analysis and individual identification are recent, promising methods that have been applied to evolutionary ecological studies, as well conservation management. Parental exclusion relying on polymorphic microsatellites has used worldwide in parentage determination, while the low mutation rate genotyping error of single nucleotide polymorphisms (SNPs) make them another important marker for pedigree tracing. Here, we compared effectiveness SNP markers European pigs. We also measured...
Genome-wide transcriptomic studies in humans and mice have become extensive mature. However, a comprehensive systematic understanding of protein-coding genes long non-coding RNAs (lncRNAs) expressed during pig spleen development has not been achieved. LncRNAs are known to participate regulatory networks for an array biological processes. Here, we constructed 18 RNA libraries from developing fetal (55 days before birth), postnatal spleens (0, 30, 180 2 years after the samples 2-year-old Wild...
Abstract Animal domestication is a long‐term, multistage process that results in modifications of many traits, especially the less aggressive behavior domesticated animals. In this study, we used Illumina RNA ‐seq to compare transcriptome brain frontal cortex between wild boar and Rongchang pig, typical indigenous domestic pig China, revealed 604 genes 639 were specifically detected respectively, with distinct functional characteristics may be related their respective environment. addition,...
Livestock have undergone domestication and consequently strong selective pressure on genes or genomic regions that control desirable traits.To identify selection signatures in the genome of Chinese Rongchang pigs, we generated a total about 170 Gb DNA sequence data with 6.4-fold coverage for each six female individuals.By combining these publically available 10 Asian wild boars, identified 449 protein-coding which are mainly involved growth hormone binding, nervous system development, drug...
DNA methylation is an important component of the epigenetic machinery and plays a critical role in transcriptional regulation.It mostly occurs CpG abundant regions, known as islands (CGIs).G protein-coupled receptor 120 (GPR120) functions omega-3 fatty acid involved multiple-biological processes, including lipogenesis.Herein, we show that GPR120 highly expressed porcine mature adipose tissue positively associated with development (r = 0.86, P < 0.01).We also predicted 5 CGIs across genomic...
Mule duck is vitally important to the production of global meat. Here, we present two high-quality haplotypes a female mule (haplotype 1 (H1):1.28 Gb, haplotype 2 (H2): 1.40 Gb). The continuity (H1: contig N50 = 14.90 Mb, H2: 15.70 Mb) and completeness (BUSCO: H1 96.9%, H2 97.3%) are substantially better than those other genomes. We detected structural variations (SVs) in H2. observed positive correlation between autosome length number SVs. Z chromosome was some deficient deletions...
Higher-order chromatin structures play important roles in regulating multiple biological processes such as growth and development well biotic abiotic stress response. However, little is known about three-dimensional Paulownia or whole-genome conformational changes that occur response to witches' broom (PaWB) disease. We used high-throughput chromosome conformation capture (Hi-C) obtain genome-wide profiles of both healthy phytoplasma-infected fortunei genome. The heat map results indicated...