A5101742314- Adipose Tissue and Metabolism
- Animal Genetics and Reproduction
- Ovarian cancer diagnosis and treatment
- Liver Disease Diagnosis and Treatment
- Geotechnical Engineering and Soil Stabilization
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Receptor Mechanisms and Signaling
- T-cell and B-cell Immunology
- Advanced Photocatalysis Techniques
- Renin-Angiotensin System Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Lipid metabolism and biosynthesis
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Endometrial and Cervical Cancer Treatments
- Geotechnical Engineering and Underground Structures
- Inflammatory mediators and NSAID effects
- Reproductive Biology and Fertility
- Automotive and Human Injury Biomechanics
- Genetic diversity and population structure
- Catalysis and Hydrodesulfurization Studies
Second Affiliated Hospital of Zhejiang University
2014-2025
Shandong Provincial Hospital
2013-2024
Shandong First Medical University
2019-2024
Shihezi University
2024
State Forestry and Grassland Administration
2021-2024
Institute of Chemical Industry of Forest Products
2021-2024
Zhejiang Ocean University
2019-2024
First Affiliated Hospital of Shihezi University Medical College
2023-2024
Central South University
2024
Ansteel (China)
2008-2024
Ning Li and colleagues report the whole-genome sequence of duck, Anas platyrhynchos, a natural host avian influenza viruses. They examine response to infection by comparing lung transcriptomes ducks that were infected with A The duck (Anas platyrhynchos) is one principal hosts We present genome perform deep transcriptome analyses investigate immune-related genes. Our data indicate possesses contractive immune gene repertoire, as in chicken zebra finch, this repertoire has been shaped through...
The pathological hallmark of Alzheimer disease is deposition amyloid-beta protein (Abeta) in the brain. Telmisartan a unique angiotensin II receptor blocker with peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-stimulating activity. Activation PPAR-gamma expected to prevent inflammation and Abeta accumulation We investigated possible preventive effect telmisartan on cognitive decline an mouse model via activation. Here, male ddY mice underwent ICV injection 1-40. Cognitive...
High-calorie food leads to nonalcoholic fatty liver disease (NAFLD) through dysregulation of genes involved in lipid metabolism, but the precise mechanism remains unclear. DNA methylation represents one mechanisms that contributes gene expression via interaction with environmental factors. Berberine can alleviate db/db and ob/ob mice. Here, we investigated whether is pathogenesis NAFLD induced by a high-fat diet (HFD) berberine improves influencing status promoters key genes. HFD markedly...
Biological piezoelectric materials have significant potential for bone repair and energy harvesting owing to their excellent biocompatibility effect. The BaTiO3/Ca10(PO4)6(OH)2 (BT/HA) composite material is an outstanding representative of biological materials, which has not been individually designed using digital light processing (DLP) 3D printing because the large difference in refractive index its components. Therefore, this work, double-sided-tooth plate-like BT crystals with high...
Znln2S4 has great prospects for photocatalytic water splitting to hydrogen by visible light. Herein, a novel Znln2S4–In-MOF (ZnInMS4) photocatalyst is elaborately synthesized in situ method with In-MOF as the template and In3+ source. ZnInMS4 overcomes fast interface charge recombination sluggish lifetime via formed heterojunctions. Photoelectrochemical measurements reveal that charge-transfer kinetics enhanced since introduced act reliable charge-transport channel. exhibits outstanding...
We reported previously that an angiotensin II type 1 receptor blocker, telmisartan, improved cognitive decline with peroxisome proliferator-activated receptor-γ activation; however, the detailed mechanisms are unclear. Enhanced blood-brain barrier (BBB) permeability alteration of tight junctions is suggested to be related diabetes mellitus. Therefore, we examined possibility telmisartan could attenuate BBB impairment activation improve mellitus–induced decline. Type 2 diabetic mice KKA y...
Our previous study found that thyroid-stimulating hormone promoted sterol regulatory element-binding protein-2 (SREBP-2) expression and suppressed AMP-activated protein kinase (AMPK) activity in the liver, but it was unclear whether there a direct link between TSH, AMPK SREBP-2. Here, we demonstrate 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR)-induced activation of directly inhibited SREBP-2 its target genes HMGCR HMGCS, which are key enzymes cholesterol biosynthesis,...
Abstract Background Esophageal squamous cell carcinoma (ESCC) is a deadly gastrointestinal malignancy, and chemotherapy resistance key factor leading to its poor prognosis. M2 tumor-associated macrophages (M2-TAMs) may be an important cause of chemoresistance in ESCC, but exact mechanism still unclear. Methods In order study the role M2-TAMs ESCC chemoresistance, CCK-8, clone formation assay, flow cytometric apoptosis qRT-PCR, western blotting, serum-free sphere assays were used. vivo animal...
In this study, we aimed to validate the performance of PAX1 and JAM3 methylation (PAX1
Abstract Based on the known partial cDNA sequence of dragline silk protein an artificial gene monomer, a 360 bp sequence, was designed and polymerized to encode analog protein. Six tandem copies monomer were cloned into pBC1 vector microinjected pronuclei fertilized Kunming White eggs. Transgenic mice screened by Polymerase Chain Reaction (PCR) Southern blot which revealed that 10 (5 male, 5 female) among 58 transgenic positive. Milk five F0 eight F1 analyzed Western blot, two seven...
Obesity-dependent insulin resistance and type 2 diabetes mellitus are closely associated with decreased glucose utilization down-regulation of hepatic glycolytic enzymes expression. Previously, we showed that DNA hypermethylation is involved in age-dependent susceptibility to diabetes. However, what cannot distinguish whether the age-related obesity contributes those natural aging rats. In present study, hypothesize methylation plays a crucial role regulation high-fat diet-induced obesity....
Objectives The role of angiotensin II type 2 (AT2) receptor stimulation in the pathogenesis insulin resistance is still unclear. Therefore we examined possibility that direct AT2 by compound 21 (C21) might contribute to possible insulin-sensitizing/anti-diabetic effects diabetes (T2DM) with PPARγ activation, mainly focusing on adipose tissue. Methods T2DM mice, KK-Ay, were subjected intraperitoneal injection C21 and/or a antagonist, GW9662 drinking water for weeks. Insulin was evaluated oral...
Stroke is a leading cause of death and disability; however, meta-analysis randomized controlled trials blood pressure–lowering drugs in acute stroke has shown no definite evidence beneficial effect on functional outcome. Accumulating suggests that angiotensin II type 1 receptor blockade with 2 (AT2) stimulation could contribute to protection against ischemic brain damage. We examined the possibility direct AT2 by compound 21 (C21) initiated even after can prevent was induced middle cerebral...
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic triglyceride accumulation, ranging from steatosis to steatohepatitis and cirrhosis. NAFLD a risk factor for cardiovascular diseases associated with metabolic syndrome. Antihyperlipidemic drugs are recommended as part of the treatment patients. Although fibrates activate peroxisome proliferator-activated receptor α (PPARα), leading reduction serum levels, effects these on remain controversial. Clinical studies have reported...
Epidemiological evidence indicates that thyrotropin (TSH) is positively correlated with the severity of obesity. However, mechanism remains unclear. Here, we show TSH promoted triglyceride (TG) synthesis in differentiated adipocytes a thyroid hormone-independent manner. Mice subclinical hypothyroidism, which characterized by elevated serum but not hormone levels, demonstrated 35% increase total white adipose mass compared their wild-type littermates. Interestingly, Tshr KO mice, had normal...
Chicken egg lysozyme (cLY) is an enzyme with 129 amino acid (AA) residue enzyme. This present not only in chicken white but also mucosal secretions such as saliva and tears. The antibacterial properties of can be attributed to the presence lysozyme, which used anti-cancer drug for treatment human immunodeficiency virus (HIV) infection. In this study, we constructed a lentiviral vector containing synthetic cLY signal peptide 447 bp (hLY) cDNA sequence driven by oviduct-specific ovalbumin...
To improve the reactivity and enrich functionality of lignin for valorization, kraft was depolymerized demethylated via cleaving aryl alkyl ether bonds in acidic lithium bromide trihydrate (∼60% LiBr aqueous solution). It found that cleavage followed order β-O-4 > phenylcoumaran dialkyl resinol methoxyl (MeO). The depolymerization occurred under mild conditions (e.g., <0.5 M HCl at 110 °C), while sufficient demethylation needed harsher (>1.5 HCl). Both generated new aromatic hydroxyl (ArOH)....
Introduction The prognosis for epithelial ovarian cancer (EOC) is exceedingly poor, with patients diagnosed stage III/IV tumours typically offered cytoreductive surgery in conjunction chemotherapy as a standard treatment option. This approach intended to reduce the risk of and address cancers that are not amenable surgical intervention. A promising alternative important option neoadjuvant (NACT) interstitial tumour surgery. combination immunotherapy has recently demonstrated remarkable...