A5101445592- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Sarcoma Diagnosis and Treatment
- Immune cells in cancer
- Circular RNAs in diseases
- TGF-β signaling in diseases
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Genomic variations and chromosomal abnormalities
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Wnt/β-catenin signaling in development and cancer
- Kruppel-like factors research
- Fibroblast Growth Factor Research
- Renal cell carcinoma treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Hedgehog Signaling Pathway Studies
- Galectins and Cancer Biology
- Cancer-related Molecular Pathways
Shihezi University
2016-2025
Chengdu Institute of Biology
2024
Chinese Academy of Sciences
2024
University of Chinese Academy of Sciences
2024
Blood Center of Zhejiang Province
2024
Central South University
2023
Jiangsu University
2021
First People's Hospital of Kunshan
2021
Ministry of Education of the People's Republic of China
2015
Huazhong University of Science and Technology
2015
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, serves as a conduit for migration. Targeting oncogenes involved in angiogenesis needed treat organ-confined locally advanced ESCC. Although phospholipase C epsilon-1 (PLCE1) gene was originally identified susceptibility ESCC, how PLCE1 ESCC unclear. Matrix-assisted laser desorption ionization time-of-flight mass...
MicroRNAs (miRNAs) are a large family of small, non-coding RNAs that play pivotal role in tumorigenesis. miR‑34a, which is member the miR-34 family, downstream target p53. Increasing evidence shows miR-34a dysregulation may contribute to tumor development and progression numerous cancers, including esophageal squamous cell carcinoma (ESCC). However, mechanism regulation ESCC cells need be further elucidated because complex regulative network miRNAs. The expression samples has been confirmed...
Abstract Ferroptosis can activate immune response via inducing tumor cells immunogenic cell death (ICD), and antitumor immunity in turn boosts the efficacy of ferroptosis by excreting interferon gamma (IFN‐ γ ), which shows a promising combo for synergistically amplified treatment. However, their combination is strictly limited complexity microenvironment, including poor immunosuppressive factors tumor. Herein, metal‐phenolic networks (MPNs) nanoplatform with all‐active components...
Abstract Background Esophageal squamous cell carcinoma (ESCC) is a deadly gastrointestinal malignancy, and chemotherapy resistance key factor leading to its poor prognosis. M2 tumor-associated macrophages (M2-TAMs) may be an important cause of chemoresistance in ESCC, but exact mechanism still unclear. Methods In order study the role M2-TAMs ESCC chemoresistance, CCK-8, clone formation assay, flow cytometric apoptosis qRT-PCR, western blotting, serum-free sphere assays were used. vivo animal...
Invasion and metastasis are the major causes of death in patients with esophageal squamous cell carcinoma (ESCC). Epithelial-mesenchymal transition (EMT) is a critical step tumor progression transforming growth factor-β1 (TGF-β1) signaling has been shown to play an important role EMT. In this study, we investigated how TGF-β1 pathways contributed EMT three ESCC lines as well 100 nomadic ethnic Kazakhs residing northwest Xinjiang Province China. vitro analyses included Western blotting detect...
Abstract Membrane type 1-matrix metalloproteinase (MT1-MMP) is associated with enhanced tumorigenicity in many cancers. A recent study has revealed that MT1-MMP induces epithelial-to-mesenchymal transition (EMT) prostate and breast cancer cells. However, its role esophageal squamous cell carcinoma (ESCC) not been studied. Here, we investigated the of dissemination ESCC. Expression was detected by immunohistochemistry tissue microarray 88 Kazakh ESCC patients. Western blotting performed to...
Atherosclerosis (AS) is a prevalent inflammatory vascular disease characterized by plaque formation, primarily composed of foam cells laden with lipids. Despite lipid-lowering therapies, effective clearance remains challenging due to the overexpression CD47 molecule on apoptotic cells, inhibiting macrophage-mediated cellular efferocytosis and resolution. Moreover, AS lesions are often associated severe inflammation oxidative stress, exacerbating progression. Herein, we introduce...
Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with dismal prognosis and high incidence mortality in Kazakh population. MiR-34a, a direct p53 target gene, possesses tumor-suppressive properties as they mediate apoptosis, cycle arrest, senescence. The reduced expression of miR-34a by methylation various cancers has been reported. To determine whether aberrant occurs esophageal cancer, the DNA 23 CpGs sites promoter was quantitatively analyzed relation to translation...
// Xiao-Bin Cui 1, 2, * , Su Li 3, Ting-Ting Hao Peng 1 Jin Shu-Mao Zhang Chun-Xia Liu Lan Yang Yao-Yuan Shen 4 Shu-Gang Na 5 Yong 6 Jian-Ming Hu Jin-Fang Jiang Jing Suo Yan Qi Wei-Hua Liang Liang-Hai Wang Hong-Wei Dang Wei-Wei Cao 7 Yutao Wei 8 Laibo-Yin Chuan-Yue Wu 9 Xiang-Lin Yuan 2 Hong Zhou 10 Yu Zheng Yun-Zhao Chen Feng Department of Pathology and Key Laboratory for Xinjiang Endemic Ethnic Diseases, Shihezi University School Medicine, Shihezi, China Oncology, Tongji Hospital, Huazhong...
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressively malignant tumors with dismal prognosis. Profilin 2 (PFN2) an actin-binding protein that regulates dynamics actin polymerization and plays a key role in motility. Recently, PFN2 have emerged as significant regulators cancer processes. However, clinical significance biological function ESCC remain unclear. expression was validated by immunohistochemistry (IHC) on tissue microarray from Chinese Han Kazakh populations...
Esophageal squamous cell carcinoma (ESCC) is a highly lethal cancer, and its underlying molecular mechanisms are poorly understood. Recent large-scale genome-wide association studies in Chinese Han populations have identified an ESCC susceptibility locus within the SLC39A6 gene. Here, we sought to explore expression biological function of ESCC.Multiethnic validation protein was performed different cohorts patients from Kazakh Xinjiang region by immunohistochemistry. The associations among...
Tumour-associated macrophages (TAMs) play an important role in the growth, progression, and metastasis of tumours. Epithelial-mesenchymal transition (EMT) is a mechanism for tumour invasion metastasis. In this study, we aimed to determine whether TAMs can induce EMT Kazakh oesophageal squamous cell cancer (ESCC).CD163 was used as marker TAMs, density nest surrounding stroma quantified using immunohistochemistry (IHC). IHC staining evaluate expression E-cadherin (epithelial marker) vimentin...
Abstract Esophageal squamous cell carcinoma (ESCC) is one of the deadliest malignant diseases. Multiple studies with large clinic-based cohorts have revealed that variations phospholipase C epsilon 1 (PLCE1) correlate esophageal cancer susceptibility. However, causative role PLCE1 in ESCC has remained elusive. Here, we observed hypomethylation-mediated upregulation expression was implicated carcinogenesis and poor prognosis cohorts. inhibited autophagy suppressed protein p53 various...
BackgroundMetastasis of rhabdomyosarcoma (RMS) is the primary cause tumour-related deaths. Previous studies have shown that overexpression guanine nucleotide exchange factor T (GEFT) correlated with a poorer RMS prognosis, but mechanism remains largely unexplored.MethodsWe focused on determining influence GEFT-Rho-GTPase signalling pathway and epithelial–mesenchymal transition (EMT) or mesenchymal–epithelial (MET) progression metastasis by using cell lines, BALB/c nude mice cells molecular...
The involvement of human papillomavirus (HPV) in the carcinogenesis esophageal squamous carcinoma remains undetermined. However, three genome-wide association studies cancer have identified a shared susceptibility locus at 10q23 (rs2274223: A5780G) phospholipase C epsilon 1 (PLCE1). current study aims to present comprehensive and novel spectrum about HPV genotype distribution Kazakhs assess its with PLCE1 polymorphisms. genotypes 183 patients 89 controls selected from Kazakh population were...
Soft tissue sarcomas (STSs) are a rare and fascinating group of diseases that can be subdivided into specific reciprocal translocations in STSs (SRTSs) nonspecific (NRTSs). PTEN mutations STSs, suggesting expression may lost by alternative mechanisms such as methylation. In order to reveal whether aberrant methylation occurs MassARRAY Spectrometry was carried detect patterns STSs. We evaluated levels 41 CpG sites from −2,515 −2,186 bp (amplicon A) −1,786 −1,416 B) relative the translation...