A5103137364- Nanoplatforms for cancer theranostics
- Cancer Research and Treatments
- Advanced Computational Techniques and Applications
- Graphene and Nanomaterials Applications
- Bacteriophages and microbial interactions
- Extracellular vesicles in disease
- RNA Interference and Gene Delivery
- Rheumatoid Arthritis Research and Therapies
- Immune cells in cancer
- Data Management and Algorithms
- Technology and Security Systems
- Reproductive System and Pregnancy
- Innovative Education and Learning Practices
- Atherosclerosis and Cardiovascular Diseases
- Geographic Information Systems Studies
- Education and Technology Integration
- Structural Engineering and Vibration Analysis
- Bone and Joint Diseases
- E-Learning and Knowledge Management
- Advanced Decision-Making Techniques
- Advanced biosensing and bioanalysis techniques
- Educational Innovations and Technology
- Autoimmune and Inflammatory Disorders Research
- Sarcoidosis and Beryllium Toxicity Research
- Genetics and Neurodevelopmental Disorders
Central South University
2020-2025
Xiangya Hospital Central South University
2021
University of Waikato
2021
Third Xiangya Hospital
2020
Beihua University
2018
Luoyang Normal University
2013
Capital Normal University
2011
Abstract Macrophages play essential roles in the progression of rheumatoid arthritis (RA), which are polarized into pro‐inflammatory M1 phenotype with significant oxidative stress and cytokines excretion. Herein, an active targeting nanomedicine based on metal‐organic frameworks (MOFs) to re‐educate diseased macrophages for RA therapy is reported. The MOFs prepared via coordination between tannic acid (TA) Fe 3+ , anti‐TNF‐α siRNA loaded a simple sonication process, achieving high loading...
Salmonella selectively colonizes into the hypoxic tumor region and exerts antitumor effects via multiple mechanisms, while colonized recruits host neutrophils tumor, presenting a key immunological restraint to compromise efficacy. Here, we develop combinatorial strategy by employing silver nanoparticles (AgNPs) improve efficacy biosafety of Salmonella. The AgNPs were decorated with sialic acid (SA) allow selective recognition L-selectin on neutrophil surfaces, based which tumor-homing was...
Abstract Bacteria‐based microbial immunotherapy shows various unique properties for tumor therapy owing to their active tropism and multiple anti‐tumor mechanisms. However, its clinical benefit is far from satisfactory, which limited by rapid systemic clearance neutrophils‐mediated immune restriction compromise the efficacy, as well non‐specific distribution cause toxicity. To address all these limitations, herein we reported a polyserotonin (PST) coated Salmonella ( Sal ) with surface...
The current world crisis of COVID-19 has enforced international lockdowns in educational institutions, necessitating that these institutions quickly transition to online learning. In mathematics education studies, where collaborative problem-solving is considered a necessary pedagogical approach, lecturers have had challenges incorporating an authentic manner. There are now also complex living and learning contexts which the students undertake their processes. This paper examines students’...
Autologous cancer vaccine that stimulates tumor-specific immune responses for personalized immunotherapy holds great potential tumor therapy. However, its efficacy is still suboptimal due to the immunosuppressive microenvironment (ITM). Here, we report a new type of bacteria-based autologous by employing calcium carbonate (CaCO3) biomineralized Salmonella (Sal) as an in-situ producer and systematical ITM regulator. CaCO3 can be facilely coated on Sal surface with ionophore A23187 co-loading,...
Atherosclerosis (AS) is a prevalent inflammatory vascular disease characterized by plaque formation, primarily composed of foam cells laden with lipids. Despite lipid-lowering therapies, effective clearance remains challenging due to the overexpression CD47 molecule on apoptotic cells, inhibiting macrophage-mediated cellular efferocytosis and resolution. Moreover, AS lesions are often associated severe inflammation oxidative stress, exacerbating progression. Herein, we introduce...
Gene therapy that employs therapeutic nucleic acids to modulate gene expression has shown great promise for diseases therapy, and its clinical application relies on the development of effective vector. Herein a novel delivery strategy by just using natural polyphenol (-)-epigallocatechin-3-O-gallate (EGCG) as raw material is reported. EGCG first intercalates into yield complex, which then oxidizes self-polymerizes form tea polyphenols nanoparticles (TPNs) encapsulation. This general method...
Atherosclerosis (AS) is a major contributor to cardiovascular diseases, necessitating the development of novel therapeutic strategies alleviate plaque burden. Macrophage efferocytosis, process by which macrophages clear apoptotic and foam cells, plays crucial role in regression. However, this impaired AS lesions due overexpression CD47, produces "do not eat me" signal. In study, we investigated potential CpG, toll-like receptor 9 agonist, enhance macrophage efferocytosis for therapy. We...
With the continuous development of science and technology, more technologies such as computers have been put into actual teaching work.Li's computer-assisted music model can just make up for single exam-oriented education.Based on this article carries out design a digital course system.The system easily digitally process recorded sound present it in form waves computer.It visually edit audio save specific training status database comprehensively, providing information training.Intuitive...
SNCA, GBA, and VPS35 are three common genes associated with Parkinson's disease. Previous studies have shown that these may be Alzheimer's disease (AD). However, it is unclear whether increase the risk of AD in Chinese populations. In this study, we used a targeted gene sequencing panel to screen all exon regions nearby sequences cohort including 721 patients 365 healthy controls from China. The results revealed neither variants nor rare were population. These findings suggest mutations not...
In order to solve the deficiencies of high degree coupling in traditional WebGIS spatial analysis function development, this paper attempts use service-oriented architecture and apply geoprocessing service perform analysis. On basis studying architecture, we establish framework. framework, take realize WebGIS, verify feasibility using services via examples.
Undering the background of campus informationization construction becomes mature day after day, it is a meaningful work to design research management information system improve level and efficiency university.This study took college university for experimental object, used Visual Studio2008 development platform, SQLServer2005 backend database, c# as language ASP.net technology, then designed Web-based college.The mainly realized all kinds query, data scientific statistics analysis functions.
In view of the current university choosing information query results in intuitive, legibility and comparative difference, space positioning, spatial analysis visualization expression is not enough, we designed a college entrance examination select service system based on WEBGIS.The used ArcGIS for data representation method, B/S mode, it can realize fractional line colleges universities, match to GIS database map, also result diversification expression, thus then improve efficiency selection...
Following the development of information technology, traditional medical teaching faced huge challenge. E-learning is a method that transmitted knowledge to students through network with computer standardized techniques. As good complement teaching, became focus education. but for some complicated reasons, this did not achieve results we expected, considering construction and application in campus, proposed strategies make full use E-learning.
The mining and application of data in sports training through intelligent computer-aided research, this paper proposes a system development design method to improve the efficiency visualization reduce cost by using Python language handle high programming convenience charts.Thus, it further improves interactivity information management stability managing data.This is preliminary exploration Echarte technology programs.Because integration programs with computer technology, still needs be...