Lei Yang

ORCID: 0000-0001-7618-9936
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About
Contact & Profiles
Research Areas
  • Viral-associated cancers and disorders
  • Hearing, Cochlea, Tinnitus, Genetics
  • Cytomegalovirus and herpesvirus research
  • Noise Effects and Management
  • Hearing Loss and Rehabilitation
  • Liver Disease Diagnosis and Treatment
  • MicroRNA in disease regulation
  • RNA Interference and Gene Delivery
  • Cholesterol and Lipid Metabolism
  • Drug Transport and Resistance Mechanisms
  • Nerve injury and regeneration
  • Parvovirus B19 Infection Studies
  • Alcohol Consumption and Health Effects
  • Vestibular and auditory disorders
  • Epigenetics and DNA Methylation
  • Cancer-related molecular mechanisms research
  • RNA modifications and cancer
  • Genetic Associations and Epidemiology
  • Metabolomics and Mass Spectrometry Studies
  • Lymphoma Diagnosis and Treatment
  • Birth, Development, and Health
  • Telomeres, Telomerase, and Senescence
  • Liver physiology and pathology
  • Circular RNAs in diseases
  • Genomics, phytochemicals, and oxidative stress

Hangzhou Normal University
2016-2025

Southern Medical University
2025

Nanfang Hospital
2025

China Medical University
2025

Jiangmen Wuyi Traditional Chinese Medicine Hospital
2024

Xinjiang Uygur Autonomous Region Uygur Medicine Hospital
2024

Beijing Tongren Hospital
2023-2024

Wuhan University
2023-2024

Linyi University
2024

Zhongnan Hospital of Wuhan University
2024

A growing number of epidemiologic studies have estimated associations between type 2 diabetes mellitus and exposure to metals. However, on the internal assessments metal gestational (GDM) are limited in scope inconsistent outcomes.This investigation aimed explore urinary nickel (Ni), arsenic (As), cadmium (Cd), antimony (Sb), cobalt (Co), or vanadium (V) early pregnancy subsequent risk GDM Chinese pregnant women.The study population included 2090 women with singleton from Tongji Maternal...

10.1016/j.envint.2019.105370 article EN cc-by-nc-nd Environment International 2019-12-18

Sex disparities in acute large vessel occlusion (LVO) following endovascular treatment (EVT) have been recently reported. However, there is uncertainty about the effect of sex differences on functional outcomes after EVT, particularly an Asian population. The present study aimed to compare clinical and safety between men women with anterior circulation LVO treated EVT.

10.1161/strokeaha.122.041195 article EN Stroke 2023-01-23

Background Sensitive and specific detection of liver cirrhosis is an urgent need for optimal individualized management disease activity. Substantial studies have identified circulation miRNAs as biomarkers diverse diseases including chronic diseases. In this study, we investigated the plasma miRNA signature to serve a potential diagnostic biomarker silent cirrhosis. Methods A genome-wide microarray was first performed in 80 specimens. Six candidate were selected then trained CHB-related...

10.1371/journal.pone.0066577 article EN cc-by PLoS ONE 2013-06-21

10.1016/j.clinre.2019.02.003 article EN Clinics and Research in Hepatology and Gastroenterology 2019-03-09

Abstract Despite increasing preventive efforts, pressure injury still occurs in intensive care patients. This study was aimed to describe prevalence, risk factors, and prevention practices adult a multi‐centre, one‐day, prospective point prevalence which total of 198 units from 21 provinces China participated. Overall ICU‐acquired patients were 12.26% 4.31%, respectively. Consistent with earlier reports, almost half the injuries at stage I, one‐fourth 2, most common body sites for sacral...

10.1111/iwj.13648 article EN cc-by-nc-nd International Wound Journal 2021-07-05

Abstract Xinjiang, China is an endemic area for Kaposi's sarcoma (KS) but the seroprevalence of sarcoma‐associated herpesvirus (KSHV) and risk factors remain undefined. In this study, antibodies to one KSHV latent protein (ORF73) two lytic proteins (ORF65 ORF‐K8.1) were examined in 2,228 subjects from general population 37 infected with HIV‐1 560 Hubei, a low KS incidence region. The serostatus serum sample was defined based on positive results any three serologic assays. higher Xinjiang...

10.1002/jmv.21550 article EN Journal of Medical Virology 2009-06-23

In China, demands for disease prevention and health care the prevalence of chronic non-communicable diseases have increased. TCM general hospitals are increasingly utilizing strategies prevention. This study aimed to investigate professionals' (HCPs') perceptions prevention, their knowledge, abilities provide such services in hospitals. cross-sectional investigated Chinese medicine departments five cities. A self-designed questionnaire used 400 HCPs focused on basic demographic data, demand...

10.1186/s12906-018-2273-y article EN cc-by BMC Complementary and Alternative Medicine 2018-07-05

Insufficient local levels of neurotrophic factor after spinal cord injury (SCI) are the leading cause secondary and limited axonal regeneration. Neuritin belongs to a family factors that promote neurite outgrowth, maintain neuronal survival, provide favorable microenvironment for regeneration repair nerve cells injury. However, it is not known whether exogenously applied neuritin protein has positive effect on SCI. This was investigated in present study using purified human recombinant...

10.1089/hum.2015.159 article EN Human Gene Therapy 2016-03-24

Background: This study addresses the need for a systematic analysis of research trends and hotspots in mental health rural elderly populations, field that has gained increasing attention due to growing global aging population. The previous literature explored specific issues such as loneliness, depression, social support, yet comprehensive review development, key themes, gaps remains lacking. Methods: Using CiteSpace software (CiteSpace 6.3.R1), this conducts bibliometric 1545 articles from...

10.3390/healthcare13030209 article EN Healthcare 2025-01-21

Kaposi's sarcoma-associated herpesvirus (KSHV) is etiologically related to sarcoma (KS), primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). It typically displays two different phases in its life cycle, the default latency occasional lytic replication. The epigenetic modifications are thought determine fate of KSHV infection. Previous studies elegantly depicted landscape latent viral genome vitro cell culture systems. However, physiologically relevant scenario...

10.1371/journal.ppat.1006167 article EN cc-by PLoS Pathogens 2017-01-24

Antimony (Sb) has been associated with type 2 diabetes in previous studies. However, the role of Sb incidence Gestational mellitus (GDM) remains unclear.We investigated association between exposure during early pregnancy and risk GDM.We performed a prospective study 2093 pregnant women from Tongji Maternal Child Health Cohort (TMCHC). concentrations were measured urine samples by ICP-MS. The urinary concentration GDM was assessed using robust Poisson regression model after adjustment for...

10.1016/j.envint.2018.11.072 article EN cc-by-nc-nd Environment International 2018-12-05

Occupational noise-induced hearing loss (NIHL) is one of the most prevalent occupational diseases worldwide. Few studies have been reported on applying kurtosis-adjusted noise energy (e.g., cumulative exposure, CNE-K) as a joint indicator for assessing NIHL. This study aimed to analyze effectiveness CNE-K in associated with complex typical manufacturing industries.A cross-sectional survey 1404 Chinese workers from industries was conducted. General demographic characteristics, exposure data,...

10.1097/aud.0000000000001327 article EN cc-by-nc-nd Ear and Hearing 2023-01-11

To compare the vascular structures of retina and choroid in Chinese Han Uygur populations with proliferative diabetic retinopathy (PDR) using swept-source OCTA (SS-OCTA). Fifty-three eyes 53 healthy volunteers (25 from Hans 28 Uygurs) 40 PDR patients (20 20 were included. Retinal choroidal parameters, including thickness, vessel flow density (VFD), foveal avascular zone (FAZ) area, vascularity volume index (CVV CVI) evaluated. Compared respective controls, superficial capillary plexus...

10.1016/j.pdpdt.2024.103995 article EN cc-by Photodiagnosis and Photodynamic Therapy 2024-01-28

Three recent large‐scale genome‐wide association studies ( GWAS ) in Chinese Han populations have identified an esophageal squamous cell carcinoma ESCC susceptibility locus within phospholipase C epsilon 1 PLCE1 gene, which encodes a involved intracellular signaling. The expressed , however, are inconsistent. This study examined expression by immunohistochemistry IHC from 110 ethnic Kazakh patients and 50 adjacent normal tissues NETs ). was localized cytoplasm, especially the peripheral...

10.1111/apm.12095 article EN Apmis 2013-05-09
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