A5055579318- Alzheimer's disease research and treatments
- Signaling Pathways in Disease
- Down syndrome and intellectual disability research
- Epigenetics and DNA Methylation
- Insect Resistance and Genetics
- Viral Infectious Diseases and Gene Expression in Insects
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- Cholinesterase and Neurodegenerative Diseases
- Acute Myeloid Leukemia Research
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- NF-κB Signaling Pathways
- Entomopathogenic Microorganisms in Pest Control
- Vector-Borne Animal Diseases
- COVID-19 Clinical Research Studies
- RNA Interference and Gene Delivery
- RNA Research and Splicing
- ATP Synthase and ATPases Research
- Cancer-related gene regulation
- Metabolism and Genetic Disorders
- Immune Response and Inflammation
- Mitochondrial Function and Pathology
Qilu Hospital of Shandong University
2014-2024
Wuhan Institute of Virology
2004-2024
Chinese Academy of Sciences
2004-2024
Bioscience (China)
2024
Affiliated Hospital of Qingdao University
2022
National Health and Family Planning Commission
2020-2022
Qingdao University
2022
Shandong University
2009-2017
City University of Hong Kong, Shenzhen Research Institute
2017
Allen Institute for Brain Science
2016
The molecular mechanism underlying the pathogenesis of majority cases sporadic Alzheimer's disease (AD) is unknown. A history stroke was found to be associated with development some AD cases, especially in presence vascular risk factors. Reduced cerebral perfusion a common component among factors, and hypoxia direct consequence hypoperfusion. Previously we showed that expression β-site β-amyloid precursor protein (APP) cleavage enzyme 1 (BACE1) gene BACE1 tightly controlled at both...
Neuritic plaques in the brains are one of pathological hallmarks Alzheimer's disease (AD). Amyloid β-protein (Aβ), central component neuritic plaques, is derived from β-amyloid precursor protein (APP) after β- and γ-secretase cleavage. The molecular mechanism underlying pathogenesis AD not yet well defined, there has been no effective treatment for AD. Valproic acid (VPA) most widely used anticonvulsant mood-stabilizing agents treating epilepsy bipolar disorder. We found that VPA decreased...
Abstract Background Notch1 is a potent regulator known to play an oncogenic role in many malignancies including T-cell acute lymphoblastic leukemia (T-ALL). Tumor hypoxia and increased hypoxia-inducible factor-1α (HIF-1α) activity can act as major stimuli for tumor aggressiveness progression. Although hypoxia-mediated activation of the pathway plays important cell survival invasiveness, interaction between HIF-1α has not yet been identified T-ALL. This study was designed investigate whether...
Amyloid beta protein (Abeta), the major component of neuritic plaques in Alzheimer's disease (AD), is derived from APP by sequential cleavages beta- and gamma-secretases. Beta-site cleaving enzyme 1 (BACE1) beta-secretase vivo. 2 (BACE2) homologue BACE1. The majority people with Down syndrome (DS), also called Trisomy 21 syndrome, will develop AD neuropathology after middle age. We others have shown that C99, product, Abeta are markedly increased DS. Since BACE2 located on chromosome 21, it...
The amyloid β protein (Aβ) is derived from β-amyloid precursor (APP). Cleavage of APP by β-secretase generates a C-terminal fragment (APPCTFβ or C99), which subsequently cleaved γ-secretase to produce Aβ. BACE (or BACE1), the major involved in cleaving APP, has been identified as Type 1 membrane-associated aspartyl protease. In this study, we found that treatment with proteasome inhibitors resulted an increase C99 levels, suggesting processing at site may be affected ubiquitin-proteasome...
Amyloid beta protein (Abeta) is the principal component of neuritic plaques in Alzheimer's disease (AD). Abeta derived from amyloid precursor (APP) by beta- and gamma-secretases. Beta-site APP cleaving enzyme 1 (BACE1) has been identified as major beta-secretase. BACE2 homolog BACE1. The gene on chromosome 21 implicated pathogenesis AD. However, function generation controversial. Some studies have shown that cleaved at beta-site whereas other showed it around alpha-secretase site. To...
Regulator of calcineurin 1 (RCAN1), a gene identified from the critical region Down syndrome, has been implied in pathogenesis Alzheimer's disease (AD). RCAN1 expression was shown to be increased AD brains;however, mechanism regulation is not well defined. The present study designed investigate molecular protein degradation. In addition being degraded through ubiquitin proteasome pathway, we found that lysosomal inhibition markedly time- and dosage-dependent manner. Inhibition macroautophagy...
Multidrug resistance (MDR) remains the major cause of disease relapse and poor prognosis in adults with acute myeloid leukemia (AML). Emerging evidence shows that drug not only exists against conventional chemotherapeutic drugs, but also limits efficacy new biological agents. Therefore, it is important to elucidate mechanisms through which AML patients develop resistance. MicroRNAs have been shown play an role regulating chemotherapy AML. A detailed understanding microRNA are clinically...
Acute myeloid leukemia (AML) is the most common hematological malignancy in adults, characterized by distorted proliferation and development of cells their precursors blood bone marrow. Interleukin 35 (IL‑35), a novel inhibitory cytokine secreted regulatory T (Treg) potential target used for therapeutic manipulation Treg activity order to treat cancer autoimmune diseases. To investigate role imbalance Treg-related cytokines pathogenesis AML, we measured plasma concentration three...
Acute myeloid leukemia (AML), caused by abnormal proliferation and accumulation of hematopoietic progenitor cells, is one the most common malignancies in adults. We reported here DYRK1A expression level was reduced bone marrow adult AML patients, comparing to normal controls. Overexpression inhibited cell lines increasing proportion cells undergoing G0/G1 phase. reasoned that proliferative inhibition due downregulation c-Myc DYRK1A, through mediating its degradation. Moreover, overexpression...
There is still much to uncover regarding the molecular details of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. As most abundant protein, nucleocapsid (N) protein encapsidates viral RNAs, serving as structural component ribonucleoprotein and virion, participates in transcription, replication, host regulations. Virus-host interaction might give clues better understand how virus affects or affected by its during infection identify promising therapeutic candidates....
Abstract Xinjiang, China is an endemic area for Kaposi's sarcoma (KS) but the seroprevalence of sarcoma‐associated herpesvirus (KSHV) and risk factors remain undefined. In this study, antibodies to one KSHV latent protein (ORF73) two lytic proteins (ORF65 ORF‐K8.1) were examined in 2,228 subjects from general population 37 infected with HIV‐1 560 Hubei, a low KS incidence region. The serostatus serum sample was defined based on positive results any three serologic assays. higher Xinjiang...
Angiogenesis is suggested to be important for leukemogenesis and chemosensitivity in acute myeloid leukemia (AML). The vascular endothelial growth factor (VEGF) Notch/Dll4 pathways have been identified as critical the regulation of embryonic development tumor angiogenesis. However, potential role pathway leukemia-endothelium cross-talk its functional link with VEGF remains obscure. This study assessed expression molecules primary AML investigated their biological function coculture cells...
Down Syndrome (DS) patients develop characteristic Alzheimer's Disease (AD) neuropathology after their middle age. Prominent neuronal loss has been observed in the cortical regions of AD brains. However, underlying mechanism leading to this both DS and remains be elucidated. Calcium overloading oxidative stress have implicated pathogenesis. Two major isoforms regulator calcineurin 1 (RCAN1), RCAN1.1 RCAN1.4, are detected human In report we defined transcriptional regulation RCAN1.4 by two...
Abstract The aim of this study was to characterize the serum metabolic profiles patients with Alzheimer’s disease (AD) and amnestic mild cognitive impairment (AMCI) using metabolomics based on gas chromatography–mass spectrometry (GC/MS). Serum samples were collected from AD ( n = 30) AMCI 32), normal healthy controls (NOR, 40). Metabolite performed GC/MS in conjunction multivariate statistical analysis, possible biomarker metabolites identified. Thirty‐one kinds endogenous could be...
SARS-CoV-2 viral RNA was found in 21% of the aerosol (n = 38) and 39% mask (n = 23) samples collected from Wuhan hospitals early 2020 Viable virus isolated one surgical mask, but not any positive