A5077811785- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Phylogenetic Studies
- Algal biology and biofuel production
- Physiological and biochemical adaptations
- Protein purification and stability
- Aquatic Ecosystems and Phytoplankton Dynamics
- Water Quality Monitoring Technologies
- Microbial Community Ecology and Physiology
- Pregnancy and preeclampsia studies
- Cancer-related molecular mechanisms research
- Glycosylation and Glycoproteins Research
- Machine Learning in Bioinformatics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- MicroRNA in disease regulation
- Marine and coastal ecosystems
- Marine Toxins and Detection Methods
- Reproductive biology and impacts on aquatic species
- Genetic diversity and population structure
- Neurobiology and Insect Physiology Research
- Aquatic life and conservation
- Biocrusts and Microbial Ecology
- Mycotoxins in Agriculture and Food
- Chromosomal and Genetic Variations
Guangdong Ocean University
2019-2025
Nanjing Medical University
2020-2025
State Key Laboratory of Food Science and Technology
2023-2025
Jiangnan University
2023-2025
Shandong First Medical University
2023-2025
BioSurfaces (United States)
2020-2024
University of Michigan
2020-2024
Shanghai Jiao Tong University
2005-2024
Chinese Academy of Fishery Sciences
2010-2024
Ministry of Agriculture and Rural Affairs
2022-2024
The authors compared the effectiveness of Seeking Safety group, cognitive-behavioral treatment for substance use disorder and posttraumatic stress (PTSD), to an active comparison health education group (Women's Health Education [WHE]) within National Institute on Drug Abuse's Clinical Trials Network. randomized 353 women receive 12 sessions (M = 6.2 sessions) or WHE 6.0 with follow-up assessment 1 week 3, 6, months posttreatment. Primary outcomes were Clinician Administered PTSD Scale...
Therapeutic antibody development requires selection and engineering of molecules with high affinity other drug-like biophysical properties. Co-optimization multiple properties remains a difficult time-consuming process that impedes drug development. Here we evaluate the use machine learning to simplify co-optimization for clinical-stage (emibetuzumab) displays levels both on-target (antigen) off-target (non-specific) binding. We mutate sites in complementarity-determining regions, sort...
Nanotechnology patent applications published during 1991–2008 have been examined using the "title–abstract" keyword search on esp@cenet "worldwide" database. The longitudinal evolution of number applications, their topics, and respective families evaluated for 15 national offices covering 98% total global activity. United States (USA), People's Republic China (PRC), Japan, South Korea largest nanotechnology experienced significant but different growth rates after 2000. In most repositories,...
Acetaldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme detoxifying acetaldehyde and endogenous lipid aldehydes; previous studies suggest protective role of ALDH2 against cardiovascular disease (CVD). Around 40% East Asians carrying the single nucleotide polymorphism (SNP) rs671 have an increased incidence CVD. However, in CVD beyond alcohol consumption remains poorly defined. Here we report that ALDH2/LDLR double knockout (DKO) mice decreased atherosclerosis compared with LDLR-KO...
Abstract Specificity is one of the most important and complex properties that central to both natural antibody function therapeutic efficacy. However, it has proven extremely challenging define robust guidelines for predicting specificity. Here we evaluated physicochemical determinants specificity multiple panels antibodies, including >100 clinical-stage antibodies. Surprisingly, find theoretical net charge complementarity-determining regions (CDRs) a strong predictor Antibodies with...
Bio-based isobutanol has attracted more and attention due to its wide application excellent fuel performance. Compared with ethanol, higher energy density, lower oxygen content, hygroscopicity, making it an ideal gasoline additive or substitute. been commercially produced from a variety of renewable feedstock, including corn, wheat, sorghum, barley, sugar cane by using yeast biocatalyst. The existing facility ethanol plants is acquired separate purify the fermentation broth, meaning that...
The accuracy of noninvasive continuous glucose monitoring (CGM) through near-infrared scattering is challenged by mixed signals from different compartments, where has a positive correlation with blood coefficient but negative tissue coefficient. In this study, we developed high-accuracy CGM based on OCT angiography (OCTA)-purified signals. optical (BOC) was initially extracted the depth attenuation backscattered light in and then purified eliminating surrounding tissues under guidance 3D...
Global climate change has a significant impact on fish survival and the aquaculture industry. Even highly adaptable organisms like Siluriformes are susceptible to these effects. This study investigates consequences of extreme high temperature Hong Kong catfish (Clarias fuscus), species known for its long-term habitation in tropical subtropical regions. In this study, C. fuscus were cultivated 90 days at (HT, 34 °C) normal (NT, 26 °C), followed by subjecting two groups stress (34 recovery (26...
The ability of antibodies to recognize their target antigens with high specificity is fundamental natural function. Nevertheless, therapeutic display variable and difficult-to-predict levels nonspecific self-interactions that can lead various drug development challenges, including antibody aggregation, abnormally viscosity, rapid clearance. Here we report a method for predicting the overall in terms relative risk displaying or at physiological conditions. We find individual combined sets...
The dietary supplementation of Haematococcus pluvialis is a natural, safe, and sustainable method for fish pigmentation. However, astaxanthin-rich H. cysts have poor effect in pigmenting salmonid flesh due to their rigid thick cell wall. thin-walled motile cells recently attracted attention potential advantages maintaining compound stability, easy digestion, enhancing the bioavailability carotenoids, reducing production costs. This study aimed investigate various nitrogen concentrations...
The widespread interest in antibody therapeutics has led to much focus on identifying candidates with favorable developability properties. In particular, there is broad highly repulsive self-interactions standard formulations (e.g., low ionic strength buffers at pH 5–6) for high solubility and viscosity. Likewise, also levels of non-specific interactions physiological solution conditions (PBS, 7.4) promote pharmacokinetic To what extent antibodies that possess both weak can be systematically...
Clarias fuscus, renowned for its resilience and nutritional value, is a significant aquaculture species in China. To facilitate further genetic research breeding programs this species, we generated an improved high-quality chromosome-level genome assembly of female C. fuscus using MGI, PacBio, Hi-C sequencing technologies. The final spans 982.84 Mb, with contig scaffold N50 values 36.16 Mb 37.66 respectively, successfully anchors 99.60% the sequences to 28 pseudochromosomes. We also...