Therapeutic antibody development requires selection and engineering of molecules with high affinity other drug-like biophysical properties. Co-optimization multiple properties remains a difficult time-consuming process that impedes drug development. Here we evaluate the use machine learning to simplify co-optimization for clinical-stage (emibetuzumab) displays levels both on-target (antigen) off-target (non-specific) binding. We mutate sites in complementarity-determining regions, sort...

A nanometeric plasmonic filter with a symmetrical multiple-teeth-shaped structure is investigated theoretically and numerically. tunable wide bandgap achievable by adjusting the depth number of teeth. This phenomenon can be attributed to interference superposition reflected transmitted waves from each tooth. Moreover, effects varying identical teeth are also discussed. It found that width increases continuously increasing The finite difference time domain method used simulate compute...

Early identification of antibody candidates with drug-like properties is essential for simplifying the development safe and effective therapeutics. For subcutaneous administration, it important to identify low self-association enable their formulation at high concentration while maintaining viscosity, opalescence, aggregation. Here, we report an interpretable machine learning model predicting (IgG1) variants viscosity using only sequences variable (Fv) regions. Our was trained on data (>100...

Maintaining indoor temperature in a suitable range is necessary for modern buildings. Although radiative cooling efficient keeping cool hot weather, it fails to block heat removal cold weather. Here, we presented conceptual design of switchable cooler (SRC) composed coating (RCC) and responsive part (TRP). Relying on the low thermal resistance state SRC can conduct internal external RCC dissipation while automatically switching high chilly inhibiting removal. Theoretically, revealed that...

A new filter structure and optical field modulator with ultra-high resolution based on plasmonic nano-cavity resonators is proposed numerically investigated. The consists of a square resonator connected several waveguides. All waveguides cavity are etched silver film whose size 1.1×0.75 μm. Compared traditional filters, the FWHM (full width at half-maximum) this structure's spectrum curve can be less than 7 nm; namely, has been greatly improved. also presents feature an when both inputs...

A novel and simple polarization independent grating couplers is designed analyzed here, in which the TE TM light can be simultaneously coupled into a silicon waveguide along same direction with high coupling efficiency. For polarization-insensitive coupler, efficiencies of two orthogonal polarizations are more than 60% at 1550 nm wavelength based on our optimized design parameters including period, etching height, filling factor, so on. mode maximum efficiency ~72% 30 1 dB bandwidth,...

A multilayer graphene-based tunable bandpass filter is proposed by using cascaded silicon microring resonators. Six graphene layers are embedded in the silicon-on-insulator waveguide to enhance influence on effective mode index, and a pretreatment has also been implemented compensate coupling-induced resonance frequency shifts. By tuning Fermi level of graphene, position pass band can be dynamically modulated whole communication <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML"...

Asymmetric Y junctions allow the development of a new class optical frequency mixers that utilize higher-order waveguide modes for signal processing. We measure high-contrast (>30 dB) mode sorting in asymmetric by use novel technique: efficient TM00, TM10, and TM20 mixing periodically poled lithium niobate waveguide. also demonstrate an odd-to-even wavelength converter capable spectral inversion without offset or bidirectional conversion.

Alternative to the traditional force cooling technologies, daytime radiative (DRC) has drawn widespread attention for its zero-power. A porous polymer coating based on poly (vinylidene fluoride-hexafluoropropylene) (PVDF-HFP) been reported as it excellent DRC capacity. However, performance of PVDF-HFP is affected substantially by preparation conditions, restricting application. To resolve issue, we utilize an artificial neural network (ANN) predict capacity and obtain best condition...

We propose a device to compensate for group-velocity mismatch (GVM) effects that limit the efficiency-bandwidth product in nonlinear frequency-mixing devices. Integrated wavelength-dependent delay lines are introduced periodically waveguide containing series of quasi-phase-matching (QPM) gratings. Appropriate choice time delays can GVM. have demonstrated two-stage poled lithium niobate waveguide. Two approximately 150-fs-long pulses generated 6 ps apart by second-harmonic generation two QPM...

The transmission characteristics of asymmetrical multi-teeth-shaped plasmonic waveguide structure are investigated theoretically and numerically. tunable dual flat bandgaps achieved in our proposed structure. This feature can provide a promising application for bandstop filter. In addition, according to the hybrid effects first order resonance high <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$N$...

Compared with traditional dyes, structural color has been studied widely due to several outstanding advantages. When choosing materials, both metal and dielectric materials have great potential, however compared metal, material the characteristics of low cost loss, so widely. At present, design metasurface based on is mostly carried out by manually adjusting parameters. Although good results can achieved this method, but cycle too long method not smart enough, which conducive industrial...

Nonlinear imaging in the propagation of a flat-topped circular Gaussian beam under coeffect two parallel wirelike opaque scatterers is investigated through computer simulation. The formation hot images each scatterer proved. Moreover, formations other kinds intense are found; one called interference image and pseudo-second-order image. former corresponds to fringe whose in-beam position at middle point between those scatterers. This plane quarter an object distance away from exit surface...

Switching color dynamically becomes urgent in the field of display, numerous researches have been carried out to actualize controllable structural colors. However, shape freedom has rarely explored existing studies. Here we explore relationship between grating and reflection spectrum by search algorithm, designed structures can reflect colors using Ge2Sb2Te5(GST) as phase-change materials(PCMs) layer. Numerical results establish that 36.4% sRGB space be obtained when GST crystalline state,...

Purpose Robots equipped with LiDAR sensors can continuously perform efficient actions for mapping tasks to gradually build maps. However, the complexity and scale of environment increasing, computation cost is extremely steep. This study aims propose a hybrid autonomous exploration method that makes full use data, shortens time in decision-making process improves efficiency. The experiment proves this feasible. Design/methodology/approach update module proposes full-mapping approach fully...

Based on the optical path model for nonlinear imaging, we systematically investigated propagation of flat-topped Gaussian beam which is modulated by two parallel gain-typed wirelike scatterers through computer simulation. It found that hot image each scatterer can be formed, with plane several centimeters behind predicted conjugated obtained approximate theory attenuation-typed scatterers. object distance, i.e. distance from to incident surface Kerr medium slab, has an important influence...

In order to achieve object grasping in dynamic environments for robotic manipulators, effective decisions should be made after the environment perception. When is moving, a moving tracking algorithm designed track and finally realize manipulation. Based on Robot Operating System (ROS), experiments are carried out 5-DOF manipulator. The manipulator can effectively grasp objects conveyor belt, those with random motion. experimental results indicate that very finish environments.

We demonstrate narrow-linewidth near-degenerate optical parametric generation in reverse-proton-exchange lithium niobate waveguides with quasi-group-velocity-matching, which is realized by using wavelength-selective directional couplers and tight-radius bends. With appropriate designs for 1.6 ps long pump pulses at 785.1 nm we obtained signal (idler) a time-bandwidth product as low 1.1, compared 10.5 conventional devices without quasi-group-velocity-matching. This improvement the temporal...