A5100737670- MicroRNA in disease regulation
- Healthcare and Venom Research
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Microbial Natural Products and Biosynthesis
- Circular RNAs in diseases
- Chronic Kidney Disease and Diabetes
- Traditional Chinese Medicine Studies
- Autophagy in Disease and Therapy
- Acupuncture Treatment Research Studies
- Advanced Glycation End Products research
- Congenital Heart Disease Studies
- Mobile Health and mHealth Applications
- Hepatitis B Virus Studies
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Treatment and Research
- Preterm Birth and Chorioamnionitis
- Metabolomics and Mass Spectrometry Studies
- Marine Sponges and Natural Products
- Medical Research and Treatments
- Mental Health Research Topics
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
Suzhou Municipal Hospital
2025
Nanjing University
2019-2025
Children's Hospital of Fudan University
2025
People’s Hospital of Rizhao
2025
State Key Laboratory of Biotherapy
2023-2024
Sichuan University
2020-2024
University of Pennsylvania
2024
Beijing United Family Hospital
2023
Harbin Medical University
2020-2022
First Affiliated Hospital of Harbin Medical University
2020-2022
Macroautophagy (herein referred to as autophagy) is an evolutionarily conserved self-digestive process cells adapt starvation and other stress responses. Upon starvation, autophagy induced, providing with needed nutrient supplies. We report here that Unc-51-like kinase 1 (Ulk1), a key initiator for mammalian autophagy, undergoes dramatic dephosphorylation upon particularly at serine 638 758. Phosphorylations of Ulk1 are mediated by target-of-rapamycin (mTOR) adenosine monophosphate activated...
Diabetic nephropathy (DN) affects about 40% of diabetes mellitus (DM) patients and is the leading cause chronic kidney disease (CKD) end-stage renal (ESRD) all over world, especially in high- middle-income countries. Most DN has been present for years before it diagnosed. Currently, treatment mainly to prevent or delay progression. Although many important molecules have discovered hypothesis-driven research past two decades, advances management new drug development very limited. Moreover,...
Sepsis is a major cause of mortality in intensive care units (ICUs) and continues to pose significant global health challenge, with sepsis-related deaths contributing substantially the overall burden on healthcare systems worldwide. The primary objective was construct evaluate machine learning (ML) model for forecasting 28-day all-cause among ICU sepsis patients. Data study sourced from eICU Collaborative Research Database (eICU-CRD) (version 2.0). main outcome mortality. Predictor selection...
Autism spectrum disorder (ASD) is a severe neurodevelopmental disease with high incidence and effective biomarkers are urgently needed for its diagnosis. A few previous studies have reported the detection of miRNA autism diagnosis, especially those based on bioinformatics approaches. In this study, we developed knowledge-guided model identifying biomarkers. We downloaded gene expression microarray data from GEO Database extracted genes levels that differed in ASD controls. then constructed...
Abstract With the progression of modern information techniques, such as next generation sequencing (NGS), Internet Everything (IoE) based smart sensors, and artificial intelligence algorithms, data-intensive research applications are emerging fourth paradigm for scientific discovery. However, we face many challenges to practical application this paradigm. In article, 10 discovery in precision medicine healthcare summarized future perspectives on discussed.
// Yaqun Zhu 1, 2, 3, * , Qiliang Peng Yuxin Lin 4, Li Zou 3 Peipei Shen Feifei Chen 4 Ming Min 5 Jiajia 6 Bairong 7 1 Department of Radiotherapy and Oncology, Second Affiliated Hospital Soochow University, Suzhou, China 2 Institute Suzhou Key Laboratory for Radiation Center Systems Biology, Biological Sciences Biotechnology, Donghua Shanghai, School Chemistry, Biology Material Engineering, University Science Technology, laboratory Shanghai Sciences, Chinese Academy These authors contributed...
Prostate cancer (PCa) is a fatal malignant tumor among males in the world and metastasis leading cause for PCa death. Biomarkers are therefore urgently needed to detect metastatic signature at early time. MicroRNAs small non-coding RNAs with potential be biomarkers disease prediction. In addition, computer-aided biomarker discovery now becoming an attractive paradigm precision diagnosis prognosis of complex diseases. this study, we identified key microRNAs as predicting based on network...
To compare different periods of cerclage placement in preventing preterm birth singleton pregnancies complicated by cervical incompetence. This retrospective cohort study was conducted at a tertiary hospital Shanghai, China. A total 499 undergoing prophylactic between January 1, 2021, and June 30, 2023, Shanghai East Hospital were included the study. Participants classified into early group (cerclage performed 11+ 0 to 15+ 6 weeks gestation) late 16+ 19+ gestation). The median gestational...
MicroRNAs (miRNAs) are small non-coding RNAs with the potential as biomarkers for disease diagnosis, prognosis and therapy. In era of big data biomedical informatics, computer-aided biomarker discovery has become current frontier. However, most computational models highly dependent on specific prior knowledge training-testing procedures, very few mechanism-guided or evidence-based. To best our knowledge, untill now no general rules have been uncovered applied to miRNA screening. this study,...
The pathogenesis of cancer is influenced by interactions among genes, proteins, metabolites and other small molecules. Understanding progression at the metabolic level propitious to visual decoding changes in living organisms. To date, a large number biomarkers have been measured reported, which provide an alternative method for precision diagnosis, treatment prognosis. systematically understand heterogeneity cancers, we developed database CMBD integrate scattered over literatures PubMed. At...
Introduction: The similarity between ankylosing spondylitis (AS) and ulcerative colitis (UC) in incidence rate pathogenesis has been revealed. But the common that explains relationship AS UC is still lacked, related genetic research limited. We purposed to explore shared biomarkers pathways of through integrated bioinformatics. Methods: Gene expression data were obtained GEO database. applied weighted gene co-expression network analysis (WGCNA) identify AS-related UC-related modules....
BACKGROUND:Existing research evidence indicates that breast cancer patients have different degrees of cognitive dysfunction after chemotherapy, and polymorphisms in 3 genes (catechol-O-methyltransferase, COMT; apolipoprotein E, APOE; brain-derived neurotrophic factor, BDNF) been associated with impairment. However, the role these gene modulating impairment survivors varying hormonal receptor expression is not clear at present.To explore effects genetic BDNF, APOE, COMT on regulation...
Gephyyamycin (1) owned the rare 3,12a-epoxybenz[a]anthracene ring system, and cysrabelomycin (2) possessed an acetylated cysteine group, two new angucyclinone derivatives were isolated from rice solid fermentation of marine-derived Streptomyces sp. HN-A124, actinobacterium marine sediments collected Hainan Province, China. Their structures elucidated on basis MS, NMR spectroscopic, X-ray diffration data analyses quantum chemical calculations electronic circular dichroism (ECD) spectra....