A5012821442- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Antifungal resistance and susceptibility
- Central Venous Catheters and Hemodialysis
- Burn Injury Management and Outcomes
- Intensive Care Unit Cognitive Disorders
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Fungal Infections and Studies
- Antibiotics Pharmacokinetics and Efficacy
- Family and Patient Care in Intensive Care Units
- Emergency and Acute Care Studies
- Infection Control in Healthcare
- Infective Endocarditis Diagnosis and Management
- Appendicitis Diagnosis and Management
- Pressure Ulcer Prevention and Management
- Streptococcal Infections and Treatments
- Pancreatitis Pathology and Treatment
- Trauma Management and Diagnosis
- Patient Satisfaction in Healthcare
Ghent University Hospital
2016-2025
Ghent University
2016-2025
The University of Queensland
2016-2025
Network Group (Czechia)
2023
University of Macerata
2023
Lagos State Health Service Commission
2023
Ekiti State University
2023
Ospedale di Macerata
2023
Brunel University of London
2023
Sciensano (Belgium)
2023
Chronic pulmonary aspergillosis (CPA) is an uncommon and problematic disease, complicating many other respiratory disorders, thought to affect ~240 000 people in Europe. The most common form of CPA chronic cavitary (CCPA), which untreated may progress fibrosing aspergillosis. Less manifestations include: Aspergillus nodule single aspergilloma. All these entities are found non-immunocompromised patients with prior or current lung disease. Subacute invasive (formerly called necrotising...
Rationale: The clinical relevance of Aspergillus-positive endotracheal aspirates in critically ill patients is difficult to assess.Objectives: We externally validate a algorithm discriminate Aspergillus colonization from putative invasive pulmonary aspergillosis this patient group.Methods: performed multicenter (n = 30) observational study including with one or more aspirate cultures 524). diagnostic accuracy was evaluated using 115 histopathologic data, considered the gold standard....
Staphylococcus aureus bacteremia carries high mortality rates. The clinical impact of methicillin resistance remains controversial: outcome comparisons between patients with involving methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) S are difficult to perform because important differences in severity illness.A retrospective cohort analysis 2 independent case-control analyses were performed determine compare outcomes attributable rates MSSA (n = 38) MRSA 47) critically ill...
Background. Central venous catheters are universally used during the treatment of critically ill patients. Their use, however, is associated with a substantial infection risk, potentially leading to increased mortality and costs. We evaluate clinical economic outcomes nosocomial central catheter-related bloodstream (CR-BSI) in intensive care unit (ICU) Methods. A retrospective (1992–2002), pairwise-matched (ratio case patients control subjects, 1:2 or 1:1), risk-adjusted cohort study was...
Abstract Introduction Invasive aspergillosis (IA) is a fungal infection that particularly affects immunocompromised hosts. Recently, several studies have indicated high incidence of IA in intensive care unit (ICU) patients. However, few data are available on the epidemiology and outcome patients with this setting. Methods An observational study including all positive Aspergillus culture during ICU stay was performed 30 ICUs 8 countries. Cases were classified as proven IA, putative or...
Invasive pulmonary aspergillosis is increasingly reported in patients with influenza admitted to the intensive care unit (ICU). Classification of influenza-associated (IAPA) using current definitions for invasive fungal diseases has proven difficult, and our aim was develop case IAPA that can facilitate clinical studies. A group 29 international experts reviewed insights into epidemiology, diagnosis management proposed a definition through process informal consensus. Since may wide range...
Mainly due to its extremely vulnerable population of critically ill patients, and the high use (invasive) procedures, intensive care unit (ICU) is epicenter infections. These infections are associated with an important rise in morbidity, mortality, healthcare costs. The additional problem multidrug-resistant pathogens boosts adverse impact ICUs. Several factors influence rapid spread ICU, e.g., new mutations, selection resistant strains, suboptimal infection control. Among gram-positive...
Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed provide an international picture of the extent injuries and factors associated with ICU-acquired in adult ICU patients. International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors injury mortality were assessed by generalised linear mixed-effects regression analysis. Data from...
To describe the epidemiology of intra-abdominal infection in an international cohort ICU patients according to a new system that classifies cases setting acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized diffuse peritonitis), severity disease expression (infection, sepsis, septic shock). We performed multicenter (n = 309), observational, epidemiological study including adult diagnosed...
Invasive pulmonary aspergillosis (IPA) is increasingly reported in patients with severe coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Diagnosis and management of COVID-19 associated (CAPA) are challenging our aim was develop practical guidance.A group 28 international experts reviewed current insights epidemiology, diagnosis CAPA developed recommendations using GRADE methodology.The prevalence varied between 0 33%, which may be partly due variable case...
The aim of this document was to develop standardized research definitions invasive fungal diseases (IFD) in non-neutropenic, adult patients without classical host factors for IFD, admitted intensive care units (ICUs). After a systematic assessment the diagnostic performance IFD target population already existing and laboratory tests, consensus were developed by panel experts using RAND/UCLA appropriateness method. Standardized proven candidiasis, probable deep-seated aspergillosis, pulmonary...
Abstract Introduction The diagnosis of invasive pulmonary aspergillosis, according to the criteria as defined by European Organisation for Research and Treatment Cancer/Mycoses Study Group (EORTC/MSG), is difficult establish in critically ill patients. aim this study address clinical significance isolation Aspergillus spp. from lower respiratory tract samples patients on basis medical radiological files using an adapted diagnostic algorithm discriminate proven probable aspergillosis...
Population characteristics and outcomes were retrospectively compared for critically ill patients with nosocomial bacteremia caused by antibiotic-susceptible (AB-S; n = 208) or antibiotic-resistant (AB-R; 120) gram-negative bacteria. No significant differences in severity of illness comorbidity factors seen between groups. Patients AB-R strains had a longer hospitalization before the onset bacteremia. The in-hospital mortality AB-S was 41.8%; infected strains, it 45.0% (P .576). A...
Objectives: To collect reliable, comparable and publicly available data on hospital use of antibiotics in Europe aggregated at the national level (1997–2002). Methods: Consumption systemic Anatomical Therapeutic Chemical (ATC) class J01 were collected expressed defined daily doses (DDD) per 1000 inhabitants day. Valid for 2002 15 countries, 6 year trends 10 countries. Comparison with ambulatory care (AC) consumption was possible 14 Results: In 2002, median antibiotic 2.1 DDD/1000...
Abstract Background The objective was to develop a user-friendly model predict the probability of death from acute burns soon after injury, based on burned surface area, age and presence inhalation injury. Methods This population-based cohort study included all patients admitted one six Belgian burn centres. Data 1999 2003 (5246 patients) were used mortality prediction model, data 2004 (981 for validation. Results Mortality in derivation 4·6 per cent. A score (0–10 points) devised: 0–4...