A5031373266- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Nosocomial Infections in ICU
- Mechanical Circulatory Support Devices
- Airway Management and Intubation Techniques
- Renal function and acid-base balance
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Electrolyte and hormonal disorders
- Tracheal and airway disorders
- Antibiotic Resistance in Bacteria
- Clinical Nutrition and Gastroenterology
- Antibiotic Use and Resistance
- Family and Patient Care in Intensive Care Units
- Congenital Diaphragmatic Hernia Studies
- Long-Term Effects of COVID-19
- Pneumonia and Respiratory Infections
- Liver Disease and Transplantation
- Vaccine Coverage and Hesitancy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Organ Donation and Transplantation
Istanbul University
2010-2024
Koç University
2019-2024
Amerikan Hastanesi
2023
Marmara University
2023
Hospital Posadas
2021
Acıbadem University
2015-2019
Acıbadem Kadıköy Hospital
2015
Türk Anesteziyoloji ve Reanimasyon Derneği
2012-2015
Bağcılar Eğitim ve Araştırma Hastanesi
2014
Türkisch-Deutsche Universität
2012
In Brief BACKGROUND: The aim of our study was to evaluate the pulmonary and hemodynamic effects two different recruitment maneuvers after open heart surgery. METHODS: Sixty patients undergoing coronary artery bypass surgery were randomized into three groups operation: maneuver with continuous positive airway pressure (CPAP) (CPAP-40 group, n = 20), by end-expiratory (PEEP) (PEEP-20 5 cm H2O PEEP (PEEP-5 20). CPAP-40 40 peak inspiratory applied for 30 s, then reduced 20 ventilation continued...
Objective: To describe and compare characteristics, ventilatory practices, associated outcomes among mechanically ventilated patients with different types of brain injury between neurologic nonneurologic patients. Design: Secondary analysis a prospective, observational, multicenter study on mechanical ventilation. Setting: Three hundred forty-nine intensive care units from 23 countries. Patients: We included 552 (362 stroke 190 trauma). For comparison we used control group 4,030 mixed who...
<h3>Background</h3> There are limited data on the impact of body mass index outcomes in mechanically ventilated patients. <h3>Methods</h3> Secondary analysis a cohort including 4698 patients ventilated. Patients were screened daily for management mechanical ventilation, complications (acute respiratory distress syndrome, sepsis, ventilator associated pneumonia, barotrauma), organ failure (cardiovascular, respiratory, renal, hepatic, haematological) and mortality intensive care unit. To...
Abstract Background To characterize and identify prognostic factors for 28-day mortality among patients with hospital-acquired fungemia (HAF) in the Intensive Care Unit (ICU). Methods A sub-analysis of a prospective, multicenter non-representative cohort study conducted 162 ICUs 24 countries. Results Of 1156 bloodstream infections (HA-BSI) included EUROBACT study, 96 had HAF. Median time to its diagnosis was 20 days (IQR 10.5–30.5) 9 3–15.5) after hospital ICU admission, respectively....
Currently, no vaccine against Pseudomonas is available. IC43 a new, recombinant, protein (OprF/I)-based the opportunistic pathogen, aeruginosa, major cause of serious hospital-acquired infections. has proven immunogenicity and tolerability in healthy volunteers, patients with burns, chronic lung diseases. In order to assess safety who are most at risk acquiring infections, it was evaluated mechanically ventilated ICU patients. We conducted randomized, placebo-controlled, partially blinded...
The aim of this study was to describe and compare the changes in ventilator management complications over time, as well variables associated with 28-day hospital mortality patients receiving mechanical ventilation (MV) after cardiac arrest.We performed a secondary analysis three prospective, observational multicenter studies conducted 1998, 2004 2010 927 ICUs from 40 countries. We screened 18,302 MV for more than 12 hours during one-month-period. included 812 arrest. collected data on...
Prone position and recruitment maneuvers (RM) are proposed as adjuncts to mechanical ventilation open up the lung keep it open. We studied oxygenation response a RM (composed of 30-s sustained inflation at 60 cm H2O airway pressure) performed in prone supine positions dogs after oleic acid– induced injury using an inspired O2 fraction 0.60. In one group (n = 6) first then were examined 8 15 positive end-expiratory pressure (PEEP). second sequence was reversed. positioning always improved...
Permeability changes in the blood-brain barrier (BBB) and their possible contribution to brain edema formation have a crucial role pathophysiology of septic encephalopathy. Magnesium sulfate has been shown protective effect on BBB integrity multiple experimental models. In this study we determine whether magnesium administration could any effects derangement rat model sepsis.This randomized controlled was performed adult male Sprague-Dawley rats. Intraperitoneal sepsis induced by using...
Rationale: Coronavirus disease (COVID-19) is an ongoing pandemic, in which obesity, hypertension, and diabetes have been linked to poor outcomes. Obstructive sleep apnea (OSA) associated with these conditions may influence the prognosis of adults COVID-19. Objectives: To determine effect OSA on clinical outcomes patients Methods: The current prospective observational study was conducted three hospitals Istanbul, Turkey from March 10 June 22, 2020. participants were categorized as high-risk...
Background Ventilator-associated pneumonia is the leading nosocomial infection in critically ill patients. The frequency of ventilator-associated caused by multidrug-resistant bacteria has increased recent years, and these pathogens cause most deaths attributable to pneumonia. authors, therefore, evaluated factors associated with selected critical care Methods authors prospectively recorded potential risk at time intensive unit admission. An endotracheal aspirate was obtained all patients...
Objective To investigate whether the response to sustained inflation and postinflation positive end-expiratory pressure varies between acute respiratory distress syndrome with pulmonary (ARDSp) extrapulmonary origin (ARDSexp). Design Prospective clinical study. Setting Multidisciplinary intensive care unit in a university hospital. Patients A total of 11 patients ARDSp 13 ARDSexp. Interventions 7 ml/kg tidal volume, 12–15 breaths/min rate, an inspiratory/expiratory ratio 1:2 was used during...
We aimed to describe the increased rate of Acinetobacter baumannii infections during COVID-19 pandemic and define its significance within last five years. This study was performed in a tertiary hospital with 280 beds included all patients infected A. intensive care unit between January 1, 2018, June 30, 2022. baumannii-infected 27 months before were included. Pulsed-field gel electrophoresis assess clonal relatedness. The infection control measures specified based on findings targeted...
In this prospective, randomized controlled study, we aimed to evaluate the effect of IgM-enriched immunoglobulin treatment on progression organ failure and septic shock in patients with severe sepsis.
In this study, we examined the effects of magnesium sulfate administration on brain edema and blood–brain barrier breakdown after experimental traumatic injury in rats. Seventy-one adult male Sprague-Dawley rats were anesthetized, closed head trauma was induced by allowing a 450-g weight to fall from 2-m height onto metallic disk fixed intact skull. Sixty-eight surviving randomly assigned receive an intraperitoneal bolus either 750 μmol/kg (group 4; n = 30) or 1 mL saline 2; 30 minutes...
The irritation effects of ibuprofen, a widely used non-steroidal anti-inflammatory drug (NSAID), were evaluated on mouse gastric and duodenal mucosa when suspended in 0.5% (w/v) sodiumcarboxymethylcellulose (NaCMC) solution loaded alginate beads. ionotropic gelation method was to prepare controlled release beads ibuprofen. influence various formulation factors the encapsulation efficiency, as vitro micromeritic properties, investigated. Other variables included concentration, percentage...
In Brief BACKGROUND: The aim of our study was to evaluate the pulmonary effects noninvasive ventilation (NIV) with or without recruitment maneuver (RM) after open heart surgery. METHODS: One-hundred patients undergoing coronary artery bypass surgery were randomized into four groups operation: 1) RM sustained inflation during mechanical postoperatively (RM group, n = 25); 2) combined NIV applied for 1/2-h periods every 6 h in first postoperative day tracheal extubation (RM-NIV 3) (NIV and 4)...
Abstract Introduction: Artificial liver support systems represent a potential useful option for the treatment of failure. The outcomes patients treated with fractionated plasma separation and adsorption (FPSA) system are presented. Patients methods: FPSA was performed 85 times 27 (median 3 treatments/patient) failure [85.2% acute (ALF) 14.8% acute‐on‐chronic failure] using Prometheus 4008H (Fresenius Medical Care) unit. Citrate used anticoagulation. A variety clinical biochemical parameters...
Legend 1: Figure 1 Long-term transgene expression efficiency in mMSCs after lentiviral vector transduction
BACKGROUND: The risk of muscle weakness is high in the survivors acute respiratory distress syndrome with COVID-19 following discharge from intensive care unit.AIM: To evaluate effects early rehabilitation program unit patients secondary to COVID-19.DESIGN: design study observational.SETTING: setting inpatient.POPULATION: Thirty-five were enrolled.METHODS: This was performed an a university hospital. Early consisting passive or active range motion exercises and neuromuscular electrical...
To describe the changes in ventilator management over time patients with neurologic disease at ICU admission and to estimate factors associated 28-day hospital mortality.Secondary analysis of three prospective, observational, multicenter studies.Cohort studies conducted 2004, 2010, 2016.Adult who received mechanical ventilation for more than 12 hours.None.Among 20,929 enrolled, we included 4,152 (20%) mechanically ventilated due different diseases. Hemorrhagic stroke brain trauma were most...