A5015848857- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Airway Management and Intubation Techniques
- Mechanical Circulatory Support Devices
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Trauma and Emergency Care Studies
- Thermal Regulation in Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Computational Drug Discovery Methods
- Renal function and acid-base balance
- Ion Transport and Channel Regulation
- Family and Patient Care in Intensive Care Units
- COVID-19 and healthcare impacts
- Neonatal and Maternal Infections
- Plant and fungal interactions
- Bariatric Surgery and Outcomes
- Acute Kidney Injury Research
- Anesthesia and Pain Management
- Health and Conflict Studies
Sağlık Bilimleri Üniversitesi
2020-2025
Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi
2017-2025
University of Health Science
2022-2025
Marmara University
2021
İstanbul Eğitim ve Araştırma Hastanesi
2021
Marmara Üniversitesi Eğitim ve Araştırma Hastanesi
2021
University of Health Sciences
2021
Weatherford College
2021
Istanbul University
2021
Türk Anesteziyoloji ve Reanimasyon Derneği
2020
Despite strict measures taken by many countries, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be an issue of global concern. Currently, there are no clinically proven pharmacotherapies for disease 2019, despite promising initial results obtained from drugs such as azithromycin and hydroxychloroquine. Therefore, the repurposing approved use against SARS-CoV-2 has become a viable strategy. Here, we searched that target 3C-like protease (3CLpro) viral RNA-dependent...
The COVID-19 pandemic caused by SARS-CoV-2 commenced in Wuhan China 2019 and soon spread worldwide. enters the cell binding to ACE II receptor begins viral replication. effects clinical findings of on liver, kidney, heart, gastrointestinal (GI) system especially lungs have been widely discussed. However, pancreas-another organ that also expresses II-have not studied.This work prospectively evaluated data from 316 patients who were admitted with a diagnosis pneumonia. categorized into three...
To evaluate the cardiopulmonary effect during prone position (PP) on right ventricular (RV) recovery in coronavirus disease-2019 related acute respiratory distress syndrome (C-ARDS) through transesophageal echocardiography (TEE).
Legend 1: Figure 1 Long-term transgene expression efficiency in mMSCs after lentiviral vector transduction
The early diagnosis of sepsis reduces the risk patient’s death. Gradient-based algorithms are applied to neural network models used in estimation literature. However, these become stuck at local minimum solution space. In recent years, swarm intelligence and an evolutionary approach have shown proper results. this study, a novel hybrid metaheuristic algorithm was proposed for optimization with regard weights deep sepsis. aims reach global search strategy capable exploring exploiting...
Background: The oxygenation index (OI) and oxygen saturation (OSI) are proven mortality predictors in pediatric adult patients, traditionally using mean airway pressure (P ). We introduce novel indices, replacing P with DP (ΔP insp ), MP dyn , tot assessing their potential for predicting COVID-19 acute respiratory distress syndrome (ARDS) mortality, comparing them to traditional indices. Methods: studied 361 ARDS patients 7 days, collecting ΔP OI-ΔP OI-MP OSI-ΔP OSI-MP . compared these...
Background The conflicting results of studies on intensive care unit (ICU) mortality obese patients and with acute kidney injury (AKI) reveal a paradox within paradox. aim this study was to determine the effects body mass index obesity AKI development ICU mortality.Methods 4,459 treated between January 2015 December 2019 in at Tertiary Care Center Turkey were analyzed retrospectively.Results developed more 69.8% (620). rates similar normal-weight (65.1%; 1172) overweight (64.9%; 1149). who...
Mechanical power (MP) is a promising tool for guidance of lung protective ventilation. Different equations have been proposed to calculate MP in pressure control ventilation (PCV). The aim this study introduce an easy use equation MP<inf>pcv(m-simpl)</inf> and compare it by Van der Meijden et al. (MP<inf>pcv</inf>) which considered as the reference PCV.Ventilatory parameters 206 Covid-19 ARDS patients recorded between 24-72 hours after admission intensive care unit. PCV data from these were...
Objective: In late 2019, the Coronavirus disease 2019 (COVID-19) has been pandemic worldwide, starting in Wuhan, China. this study, we aimed to evaluate factors associated with 28-day outcomes patients admitted intensive care unit diagnosis of COVID-19. Methods: This study a retrospective cohort design. COVID-19 identified according World Health Organization guidelines are included. Patient data were recorded centralized system utilizing ImdSoft-Meta vision/QlinICU Clinical Decision Support...
COVID-19 can cause a clinical spectrum from asymptomatic disease to life-threatening respiratory failure and acute distress syndrome (ARDS). There is an ongoing discussion whether the presentation ventilatory parameters are same as typical ARDS or not. no clear understanding of how hemodynamic have been affected in patients. We aimed compare moderate severe non-COVID-19 These patients were monitored with advanced measurement system by transpulmonary thermodilution method prone supine...
Background: The COVID-19 pandemic caused by SARS-CoV-2 commenced in Wuhan China 2019 and soon spread worldwide. It is a viral disease that involves many organs progresses with high mortality. enters the cell binding to ACE II receptor begins replication. A serious immune response occurs where it settles leading tissue damage. effects clinical findings of on liver, kidney, heart, gastrointestinal (GI) system especially lungs have been widely discussed. However, pancreas—another organ also...
ÖZ Amaç: Çin'in Wuhan kentinde ortaya çıkan ve tüm dünyayı etkisi altına alan koronavirüs hastalığı-2019 (COVID-19) pandemisinde mortaliteyi etkileyen risk faktörleri henüz açıkça belirlenmemiştir.Mortalite riski yüksek olan hastaların belirlenmesinde Charlson komorbidite indeksi (CCI) pnömoni şiddet (PSI) değerlendirmesi klinisyenlere yardımcı olabilir.Bu çalışmanın amacı, COVID-19 enfeksiyonunda yükünü gösteren CCI ile
Background: Increasing in emergency department need to critical care, the number of intensive care unit bed worldwide is inadequate meet these applies. Objectives: The aim this study was investigate effect waiting for admission Intensive Care Unit (ICU) Emergency Department (ED) on length stay ICU and mortality critically ill patients. Methods: This retrospective cohort carried out between January 2012 - 2019 patients admitted a training research hospital. data 1297 adult were obtained by...
Mechanical power (MP) is the amount of energy transferred from ventilator to patient within a unit time. It has been emphasized in ventilation-induced lung injury (VILI) and mortality. However, its measurement use clinical practice are challenging. "Electronic recording systems (ERS)" using mechanical ventilation parameters provided by can be helpful measure record MP. The MP (J/minutes) formula 0.098 x tidal volume respiratory rate (Ppeak - ½ ∆P), which ∆P driving pressure Ppeak peak...
Objective: The diagnosis and treatment of electrolyte acid-base imbalances in intensive care unit (ICU) patients have critical importance.The value Stewart's approach revealing disorders is known.There are parameters defined according to this approach.This study investigates the impact chloride effect (Cl Effect ), sodium (Na sodium-chloride (Na-Cl strong ion difference (SID nl ) Cl/Na ratio values calculated on ICU mortality.Materials Methods: Two thousand whose Na, Cl, K, standard base...
Intraoperative mechanical ventilation practices can lead to ventilator-induced lung injury (VILI) and postoperative pulmonary complications in healthy lungs. Mechanical power (MP) has been developed as a new concept reducing the risk of it considers all respiratory mechanics that cause VILI. The most commonly used intraoperative modes are volume control (VCV) pressure (PCV). In this study, VCV PCV were compared terms patients operated supine prone positions.
In this study, we evaluated the efficacy of intercostal nerve block for postoperative pain management in pediatric patients undergoing atrial septal defect closure through a right lateral mini-thoracotomy.Between January 2016 and 2019, total 63 (37 males, 26 females; mean age 34.8±26.8 months; range, 2 to 96 months) who underwent corrective congenital heart surgery mini-thoracotomy were retrospectively reviewed. The divided into two groups as those (Group 1, n=33) receiving general...
Objective: To compare the efficacy of pulsed-dose corticosteroids (≥250 mg methylprednisolone, 3 days) and tocilizumab in treating COVID-19-related hyperinflammation. Methods: This prospective observational study included RT-PCR positive COVID-19 patients with acute respiratory distress syndrome, who were admitted to Adult Intensive Care Unit Prof Dr. Murat Dilmener Emergency Hospital (Istanbul, Turkey) between December 1, 2020 February 28, 2021. Clinical, laboratory radiological...
Objective: This study aimed to determine the factors associated with prolonged intensive care unit length of stay (ICU-LOS), which is increasingly common in ICU, and evaluate its effect on patient outcomes.Methods: retrospective was evaluated by obtaining data 5,022 patients who were followed ICU a tertiary education research hospital between January 2014 2021 met criteria electronic environment.Results: Patients divided into two groups as ICU-LOS <14 days (n=4,083, 81.3%) ≥14 (n=939,...
Objective: To investigate the code blue application at a training and research hospital in Turkey.Methods: The declaration forms database with 238 complete records between January 2016 July 2017 were collected. form involved individual characteristics, reason for issuing call, unit block where was given, time location related properties such as working arrival duration, regarding intervention process its type, duration or result. 24-hour 30-day long survival data of patients to whom...
Objective: To investigate the effect of variability Na s , Cl K lactate values and sodium (Na Effect ), chloride (Cl non-lactate strong ion difference (SID nl ) calculated according to Stewart’s approach on predicting intensive care unit (ICU) mortality. Methods: The study was conducted 1539 patients, retrospectively. Serum serum (K Ca (Ca Mg (Mg lactate, pH SID APACHE II (first, last), SOFA last) scores were recorded. Radiometer ABL 800 (Denmark) used for blood gas analysis. each parameter...
Objective: Serum lipoprotein levels [high-density (HDL), low-density (LDL)], total cholesterol, and triglyceride) have protective functions against sepsis.Reduced are associated with organ dysfunction mortality.This retrospective cohort study aimed to investigate the relationship between serum sepsis in a large population of patients admitted intensive care unit.Methods: 151 diagnosed 450 without were analyzed retrospectively.The level decreased non-sepsis groups, appropriate statistical...
Objective: Mechanical power is a predictor of ventilator-induced lung damage.An automatic recruitment maneuver (ARM) used during anesthesia to adjust the optimal positive end-expiratory pressure (PEEP) level.This study compared total mechanical and dynamic patients who underwent sleeve gastrectomy due morbid obesity are ventilated with PEEP adjusted according anesthesiologists' decision those using ARM.Methods: Patients between ages 18 65 years, American Society Anesthesiologists (ASA) III...
Objective: The importance of prone positioning has increased with the density COVID 19-related acute respiratory distress syndrome (C-ARDS) during pandemic process.It is aimed to investigate effect prolonged duration in C-ARDS patients on blood gas parameters at time after supine (post-prone effect), feasibility, safety, and mortality for 28 days.Materials Methods: This study was a single-center prospective observational 1000 beds, 432 which were intensive care units.Severe moderate ARDS;...