A5056402672- Heat shock proteins research
- Respiratory Support and Mechanisms
- Cancer Treatment and Pharmacology
- Extracellular vesicles in disease
- Endoplasmic Reticulum Stress and Disease
- Computational Drug Discovery Methods
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Neonatal Respiratory Health Research
- Protein Structure and Dynamics
- Tissue Engineering and Regenerative Medicine
- thermodynamics and calorimetric analyses
- Sepsis Diagnosis and Treatment
- Exercise and Physiological Responses
- Pleural and Pulmonary Diseases
- Adipose Tissue and Metabolism
- Electrospun Nanofibers in Biomedical Applications
- Occupational and environmental lung diseases
- Cardiac Arrest and Resuscitation
- Gut microbiota and health
- HER2/EGFR in Cancer Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- SARS-CoV-2 and COVID-19 Research
- Alcohol Consumption and Health Effects
University of Palermo
2016-2025
Federico II University Hospital
2024
Ospedale Papa Giovanni XXIII
2021-2023
University of Naples Federico II
2022-2023
Polytechnic University of Bari
2020-2022
Advanced Cell Diagnostics (United States)
2021
University of Palermo
2017-2021
Istituto Euro Mediterraneo di Scienza e Tecnologia
2011-2020
Ospedale A. Perrino
2011-2020
Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo
2019
Rationale: Pressures and volumes needed to induce ventilator-induced lung injury in healthy lungs are far greater than those applied diseased lungs. A possible explanation may be the presence of local inhomogeneities acting as pressure multipliers (stress raisers).Objectives: To quantify patients with acute respiratory distress syndrome (ARDS).Methods: Retrospective quantitative analysis CT scan images 148 ARDS 100 control subjects. An ideally homogeneous would have same expansion all...
BACKGROUND Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation tumor development and progression not well understood value as biomarker has been fully elucidated. In the current study, authors presented evidence supporting theory that Hsp60 potential therapeutic target patients with large bowel cancer. METHODS The studied population of 97 subjects, including controls. Immunomorphology, Western blot analysis, quantitative real‐time polymerase chain...
Positive end-expiratory pressure exerts its effects keeping open at end-expiration previously collapsed areas of the lung; consequently, higher positive should be limited to patients with high recruitability. We aimed determine which bedside method would provide better related lung recruitability.Prospective study performed between 2008 and 2011.Two university hospitals (Italy Germany).Fifty-one acute respiratory distress syndrome.Whole CT scans were taken in static conditions 5 45 cm H2O...
The assessment of lung recruitability in patients with acute respiratory distress syndrome (ARDS) may be important for planning recruitment maneuvers and setting positive end-expiratory pressure (PEEP).To determine whether measured by mechanics is comparable computed tomography (CT).In 22 ARDS, was assessed at 5 15 cm H2O PEEP using mechanics-based methods: (1) increase gas volume between two pressure-volume curves (P-Vrs curve); (2) predicted on the basis expected static compliance system...
Intestinal dysbiosis seems to be the leading cause of inflammatory bowel diseases, and probiotics represent proper support against their occurrence. Actually, probiotic blends anti-inflammatory drugs a weapon diseases. The present study evaluates long-term (2 years) effects combination therapy (mesalazine plus blend Lactobacillus salivarius, acidophilus Bifidobacterium bifidus strain BGN4) on ulcerative colitis activity.Sixty patients with moderate-to-severe were enrolled: 30 them treated...
Alzheimer's disease (AD) is an aging-related multi-factorial disorder to which metabolic factors contribute at what has canonically been considered a centrally mediated process. Although the exact underlying mechanisms are still unknown, obesity recognized as risk factor for AD and condition of insulin resistance seems be link between two pathologies. Using mice with high fat diet (HFD) we dissected molecular shared by disorders. Brains HFD fed showed elevated levels APP Aβ40/Aβ42 together...
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), the cause of COVID-19 disease, has potential to elicit autoimmunity because mimicry human molecular chaperones by viral proteins. We compared proteins with chaperones, many which are heat shock proteins, determine if they share amino acid-sequence segments immunogenic-antigenic potential, can cross-reactive antibodies and effector immune cells capacity damage-destroy a mechanism autoimmunity. identified that putatively...
Liraglutide is a glucagon-like peptide-1 analog and glucose-lowering agent whose effects on cardiovascular risk markers have not been fully elucidated.
Abstract Background Septic shock is characterized by breakdown of the endothelial glycocalyx and damage, contributing to fluid extravasation, organ failure death. Albumin has shown benefit in septic patients. Our aims were: (1) identify relations between circulating levels syndecan-1 (SYN-1), sphingosine-1-phosphate (S1P) (endothelial glycocalyx), VE-cadherin cell junctions), severity disease, survival; (2) evaluate effects albumin supplementation on dysfunction patients with shock. Methods...
Dysbiosis of the maternal gut microbiome during pregnancy is associated with adverse neurodevelopmental outcomes. We previously showed that high-fat diet (MHFD) in mice induces dysbiosis, social dysfunction, and underlying synaptic plasticity deficits male offspring (F1). Here, we reason that, if HFD-mediated changes microbiota drive deficits, then MHFD-induced dysbiosis F1 female MHFD would likewise impair F2 behavior. Metataxonomic sequencing reveals reduced microbial richness among...
Abstract Background Endometrial cancer is the most common gynecologic malignancy found in developed countries. Because therapy can be curative at first, early detection and diagnosis are crucial for successful treatment. Early allows patients to avoid radical therapies offers conservative management options. There currently no proven biomarkers that predict risk of disease occurrence, enable identification or support prognostic evaluation. Consequently, there increasing interest discovering...
Abstract Heat shock protein 60 (Hsp60) is a chaperone localizing in skeletal muscle mitochondria, whose role poorly understood. In the present study, levels of Hsp60 fibres entire posterior group hindlimb muscles ( gastrocnemius , soleus and plantaris ) were evaluated mice after completing 6-week endurance training program. The correlation between expression four isoforms peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1α) investigated only . Short-term...
Although computed tomography (CT) is widely used to investigate different pathologies, quantitative data from normal populations are scarce. Reference values may be useful estimate the anatomical or physiological changes induced by various diseases.We analyzed 100 helical CT scans taken for clinical purposes and referred as nonpathological radiologist. Profiles were manually outlined on each scan slice voxel was classified according its gas/tissue ratio. For regional analysis, lungs divided...