A5002875646- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Hemodynamic Monitoring and Therapy
- COVID-19 Clinical Research Studies
- Neonatal Respiratory Health Research
- Anesthesia and Sedative Agents
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Tracheal and airway disorders
- Mechanical Circulatory Support Devices
- Anesthesia and Neurotoxicity Research
- Nosocomial Infections in ICU
- Anesthesia and Pain Management
- Non-Invasive Vital Sign Monitoring
- Cell death mechanisms and regulation
- Clinical Nutrition and Gastroenterology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Nutrition and Health in Aging
- Liver Disease Diagnosis and Treatment
- Aortic aneurysm repair treatments
Acıbadem University
2020-2024
Acıbadem Adana Hospital
2019-2023
Istanbul University
2013-2022
Sabancı Üniversitesi
2021
Taksim German Hospital
2020
Kent Hastanesi
2020
Türk Anesteziyoloji ve Reanimasyon Derneği
2011-2020
University of Iowa
2020
Türkisch-Deutsche Universität
2020
Northwestern University
2004-2005
Exposure of animals to hyperoxia results in respiratory failure and death within 72 h. Histologic evaluation the lungs these demonstrates epithelial apoptosis necrosis. Although generation reactive oxygen species (ROS) is widely thought be responsible for cell observed following exposure hyperoxia, it not clear whether they act upstream activation pathway or are generated as a result mitochondrial membrane permeabilization caspase activation. We hypothesized that ROS was required...
Objective To investigate whether the response to sustained inflation and postinflation positive end-expiratory pressure varies between acute respiratory distress syndrome with pulmonary (ARDSp) extrapulmonary origin (ARDSexp). Design Prospective clinical study. Setting Multidisciplinary intensive care unit in a university hospital. Patients A total of 11 patients ARDSp 13 ARDSexp. Interventions 7 ml/kg tidal volume, 12–15 breaths/min rate, an inspiratory/expiratory ratio 1:2 was used during...
Exposure to bleomycin in rodents induces lung injury and fibrosis. Alveolar epithelial cell death has been hypothesized as an initiating mechanism underlying bleomycin-induced In the present study we evaluated contribution of mitochondrial receptor-meditated pathways mouse alveolar cells (MLE-12 cells) primary rat type II cells. Control MLE-12 died after 48 h exposure bleomycin. Both overexpressing Bcl-X(L) did not undergo response Dominant negative Fas-associating protein with a domain...
In this prospective, randomized controlled study, we aimed to evaluate the effect of IgM-enriched immunoglobulin treatment on progression organ failure and septic shock in patients with severe sepsis.
Abstract LPS has been implicated in the pathogenesis of endothelial cell death associated with Gram-negative bacterial sepsis. The binding to TLR-4 on surface cells initiates formation a death-inducing signaling complex at surface. subsequent pathways that result apoptotic remain unclear and may differ among different organs. We sought determine whether cycloheximide-induced human lung microvascular (HmVECs) was dependent upon activation intrinsic pathway generation reactive oxygen species....
In the present study, we hypothesized that 3% hypertonic saline (HS) is more effective than 20% mannitol to reduce intracranial pressure (ICP) and modify brain bulk in patients undergoing an elective supratentorial craniotomy.After institutional review board approval, scheduled undergo craniotomy were enrolled into this prospective, randomized, double-blind study. The monitored for routine hemodynamic parameters, depth of anesthesia, ICP. They received 5 mL/kg (n=20) or HS (n=19) as infusion...
An outbreak of a new coronavirus causing severe respiratory disease (COVID-19) was first reported in China and rapidly spread worldwide. Clinical spectrum changes from asymptomatic infection to illness even death, no specific treatment is currently available. A range antiviral, antimalarial antibiotic agents are being used. We report case COVID-19 patient that progressed requiring intubation intensive care. performed mesenchymal stem cell (MSC) transplantation considering the signs showing...
Objective High peak airway opening pressures (Pao) are used routinely during recruitment maneuvers to open collapsed lung units. Pao, however, can cause injury as evidenced by translocation of intratracheally inoculated bacteria. In this study we explored whether that high Pao could the Pseudomonas aeruginosa from alveoli into systemic circulation. Design Prospective, randomized, animal study. Setting Experimental care laboratory. Subjects Eighteen male Sprague Dawley rats. Interventions...
Procalcitonin (PCT) is increasingly recognised as an important diagnostic parameter in clinical evaluation of the critically ill. This prospective study was designed to investigate PCT a marker infection ill patients with sepsis. Eighty-five adult ICU were studied. Four groups defined on basis clinical, laboratory and bacteriologic findings systemic inflammatory response syndrome (SIRS) (n = 10), sepsis 16), severe 18) septic shock 41). Data collected including C-reactive protein (CRP),...
Although COVID-19 infection is an immunosuppressant disease, many agents, such as pulse methylprednisolone (PMP), dexamethasone (DXM), and tocilizumab (TCZ), were used during the pandemic. Secondary infections in patients with have been reported recently. This study investigated these agents' effects on secondary outcomes intensive care units (ICUs). was designed retrospectively, all data collected from tertiary of six hospitals between March 2020 October 2021. All divided into three groups:...
Craniosynostosis is a condition resulting from the premature fusion of cranial sutures. Corrective surgery often associated with large amount blood loss, transfusion red cells (RBC) and fresh frozen plasma (FFP). The aims this study were to determine variables increased loss postoperative complications.A retrospective analysis was performed 42 pediatric patients who underwent craniosynostosis surgery. We analyzed following: demographic parameters, duration surgery, intraoperative RBC, FFP...
Background: Intra-abdominal hypertension due to surgical position increases bleeding at the site. In this study, we evaluated impact of prone and jackknife on intra-abdominal pressure (IAP), lung mechanics, blood loss site, duration procedure lumbar disc operations. Methods: Forty patients operated for single-space lumber herniation were included in our study. All ASA I-II 18 70 years old. Patients who had undergone previous spinal surgery, anticoagulant or anti-aggregant therapy,...
PURPOSE: To compared the effects of sevoflurane and desflurane on early anesthesia recovery in patients undergoing to craniotomy for intracranial lesions. METHODS: After IRB approval, study included 50 aged 18-70 years who had ASA physical statuses I-II were scheduled surgery. Patients randomly divided into two groups: desflurane. Anaesthesia was routinely induced all followed by 5%-6% or 1%-2%. Moreover remifentanil infusion (0.05-0.2 mcg/kg/min) adjusted maintain mean arterial pressure...
Objective: To evaluate the time course of Pao2 change following setting optimal positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome (ARDS). Design: Prospective clinical study. Setting: Multidisciplinary intensive care unit a university hospital. Patients: Twenty-five consecutive ARDS. Interventions: ARDS was diagnosed during pressure-regulated volume control ventilation tidal 7 mL/kg actual body weight, rate 12 breaths/min, inspiratory/expiratory...
Pulse pressure variation (PPV) and stroke volume (SVV) can predict fluid responsiveness effectively. However, high Body Mass Index (BMI) restrict their use due to changes in respiratory system compliance (CS), intra-abdominal pressure, (SV) the prone position. Therefore, we aimed investigate effectiveness of mini-fluid challenge (MFC) predicting obese (BMI ≥30 kg/m2) patients position.A total 33 undergoing neurosurgery were included. After standardized anesthesia induction, patients' PPV,...
BACKGROUND: Positive end-expiratory pressure (PEEP) increment induces a decrease in Stroke Volume Index (SVI). We hypothesized that the magnitude of SVI reduction due to 5 cmH2O increase PEEP could predict fluid responsiveness during low tidal volume ventilation.METHODS: Forty-eight patients completed study. Heart rate, mean arterial pressure, SVI, pulse variation (PPV) and stroke (SVV) were recorded before short-time (SLPC) challenge (applied additional for 30 seconds), SLPC after 500 mL...
Hypotension after anesthesia induction is a common problem and partly related to patient volume status. The present study aimed investigate the correlation between blood pressure change pulse variation (PPV), percentage of weight loss while determining threshold for hypotension by receiver operating characteristic analysis.We analyzed 231 neurosurgery patients. In all patients, propofol was used standard induction. Patient demographics, medical histories, fasting duration, loss, baseline...