A5061510247- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Drug Solubulity and Delivery Systems
- Advancements in Transdermal Drug Delivery
- Orthopedic Infections and Treatments
- RNA Interference and Gene Delivery
- Protein purification and stability
- Ocular Surface and Contact Lens
- Orthopaedic implants and arthroplasty
- Graphene and Nanomaterials Applications
- Bone Tissue Engineering Materials
- Dendrimers and Hyperbranched Polymers
- Total Knee Arthroplasty Outcomes
- biodegradable polymer synthesis and properties
- Analytical Chemistry and Chromatography
- Antibiotics Pharmacokinetics and Efficacy
- Radiopharmaceutical Chemistry and Applications
- Biosimilars and Bioanalytical Methods
- Enzyme Catalysis and Immobilization
- Microencapsulation and Drying Processes
- Cancer Treatment and Pharmacology
- Microfluidic and Capillary Electrophoresis Applications
- Surgical Sutures and Adhesives
- Antimicrobial agents and applications
- Corneal Surgery and Treatments
Hacettepe University
2016-2025
University of Antwerp
2005-2010
Ghent University
2010
Ankara University
2010
Pharmaceutical Biotechnology (Czechia)
2001-2005
Developing a drug delivery system, which is uniform, biocompatible, stable and non-toxic, challenging issue in anticancer strategies. Ferritin nano-size spherical protein with an internal cavity where molecules can be encapsulated. The apoferritin-doxorubicin complex has been formed by 'opening' 'closing' the apoferritin sphere presence of doxorubicin. doxorubicin encapsulation was carried out using direct step-wise change pH solution from 2.5 to 7.4. Non-denaturing polyacrylamide gels...
The physicochemical properties (size, shape, zeta potential, porosity, elasticity, etc.) of nanocarriers influence their biological behavior directly, which may result in alterations the therapeutic outcome. Understanding effect shape on cellular interaction and biodistribution intravenously injected particles could have fundamental importance for rational design drug delivery systems. In present study, spherical, rod elliptical disk-shaped PLGA nanoparticles were developed examining...
In the present study, influence of freeze-drying with several cryoprotective agents and gamma (gamma)-irradiation sterilization on physicochemical characteristics ciprofloxacin HCl-loaded poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles was evaluated. Nanoparticles were prepared by W/O/W emulsification solvent evaporation followed high-pressure homogenization. They freeze-dried in presence 5.0% (w/v) mannitol, trehalose or glucose, 15.0% dextran as cryoprotectants. The irradiated at a...
The use of polymeric carriers in formulations therapeutic drug delivery systems has gained widespread application, due to their advantage being biodegradable and biocompatible. Among the microparticulate systems, microspheres have a special importance since it is possible target drugs provide controlled release. Diclofenac sodium (DS), potent NSAID group having non-steroidal, anti-inflammatory properties, widely used treatment rheumatoid arthritis, osteoarthritis ankylosing spondylitis. In...
In this study, 5-FU, a potent anticancer drug, is planned to be delivered via new and promising drug delivery system, nanoparticles formed with hydrophobic core polymer triblock copolymers; Poly(DL-lactic acid), Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) copolymer (PLA/PEG-PPG-PEG) Poly(D,L-lactide–co-glycolide)/Poly(ethylene (PLGA/PEG-PPG-PEG) nanoparticles. Particle size range of was found between 145 198 nm, which would promote the passive targeting...
Considering the confusing biodistribution data through literature and few reported alerts as well our preliminary results, we decided to evaluate interaction interference of commonly present 99mTc (technetium-99m)-stannic oxide colloid during direct stannous chloride 99mTc-labeling procedure assess its influence on pattern amphiphilic poly(lactic-co-glycolic acid) nanoparticles. In order confirm thesis, beside chloride, employed two different reducing agents that don't form colloidal...
The irritation effects of ibuprofen, a widely used non-steroidal anti-inflammatory drug (NSAID), were evaluated on mouse gastric and duodenal mucosa when suspended in 0.5% (w/v) sodiumcarboxymethylcellulose (NaCMC) solution loaded alginate beads. ionotropic gelation method was to prepare controlled release beads ibuprofen. influence various formulation factors the encapsulation efficiency, as vitro micromeritic properties, investigated. Other variables included concentration, percentage...
Nanoparticles loaded with 5-fluorouracil (5-FU) for colon cancer therapies were prepared using the solvent evaporation technique, which involved lyophilization by freeze-drying. Formulations produced a substantially high encapsulation efficiency of approximately 93%. A positive correlation was seen when increasing polycaprolactone (PCL) and/or PVA concentrations and size nanoparticles produced. Increasing PCL concentration had considerable influence on PDI while lesser effect. All possessed...