A5070157777- Immune cells in cancer
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Immune Cell Function and Interaction
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- SARS-CoV-2 and COVID-19 Research
- Click Chemistry and Applications
- Long-Term Effects of COVID-19
- Nanoplatforms for cancer theranostics
- Neuroendocrine Tumor Research Advances
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Lung Cancer Research Studies
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Curcumin's Biomedical Applications
- Inhalation and Respiratory Drug Delivery
- Phagocytosis and Immune Regulation
- Turkish Literature and Culture
- Cancer Cells and Metastasis
Cancer Institute (WIA)
2020-2025
Hacettepe University Hospital
2016-2025
University Medical Centre Mannheim
2024
Heidelberg University
2024
German Cancer Research Center
2024
Hacettepe University
2020-2022
NYU Langone Health
2017
K-RAS is a highly relevant oncogene that mutated in approximately 90% of pancreatic cancers and 20-25% lung adenocarcinomas. The aim this work was to develop new anti-KRAS siRNA therapeutic strategy through the engineering functionalized lipid nanoparticles (LNPs). To do this, first, potent pan sequence chosen from literature different chemical modifications were tested for their transfection efficacy (KRAS knockdown) anti-proliferative effects on various cancer cell lines. Second, selected...
The physicochemical properties (size, shape, zeta potential, porosity, elasticity, etc.) of nanocarriers influence their biological behavior directly, which may result in alterations the therapeutic outcome. Understanding effect shape on cellular interaction and biodistribution intravenously injected particles could have fundamental importance for rational design drug delivery systems. In present study, spherical, rod elliptical disk-shaped PLGA nanoparticles were developed examining...
Immunotherapies for malignant melanoma are challenged by the resistance developed in a significant proportion of patients. Myeloid-derived suppressor cells (MDSC), with their ability to inhibit antitumor T-cell responses, major contributor immunosuppression and immune checkpoint therapies melanoma. Damage-associated molecular patterns S100A8, S100A9, HMGB1, acting as toll like receptor 4 (TLR4) advanced glycation endproducts (RAGE) ligands, highly expressed tumor microenvironment drive MDSC...
To cope with immune responses, tumour cells implement elaborate strategies such as adaptive resistance and induction of T-cell exhaustion. exhaustion has been identified a state hyporesponsiveness that arises under continuous antigenic stimulus. Nevertheless, contribution co-stimulatory molecules to in cancer remains be better defined. This study explores the role myeloid leukaemia-derived signals on CD4+ T helper (Th) cell exhaustion, which may limit anti-tumour immunity. Here, CD86...
Abstract Interferon (IFN)-γ is the major mediator of anti-tumor immune responses; nevertheless, cancer cells use intrigue strategies to alter IFN-γ signaling and avoid elimination. Understanding regulatory mechanisms employed by acute myeloid leukemia (AML) myelodysplastic syndrome (MDS) upon exposure critical for development immunotherapy checkpoint blockade therapy approaches. This study aims explore influence maturation on IFN-γ-induced PD-L1 PD-L2 expression pro-leukemogenic...
In contrast to the mouse, functional assets of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) in human spleen remain be better elucidated. Here, we report that gastric and pancreatic cancer adopts an immune regulatory character, harbors excessive amount PMN-MDSC, anatomically enables their interaction with T cells. Compared peripheral blood, from patients contained significantly higher levels low-density but not early-stage MDSC (e-MDSC) monocytic-MDSC (M-MDSC). Low-density...
Small cell lung cancer (SCLC) is an aggressive tumor type with early dissemination and distant metastasis capacity. Even though optimal chemotherapy responses are observed initially in many patients, therapy resistance almost inevitable. Accordingly, SCLC has been regarded as archetype for stem (CSC) dynamics. To determine the immune-modulatory influence of CSC SCLC, this study focused on characterization CD44+CD90+ CSC-like subpopulations SCLC. These cells displayed mesenchymal properties,...
Overexpression of permeability-glycoprotein (P-gp) transporter leads to multidrug resistance (MDR) through cellular exclusion chemotherapeutics. Co-administration P-gp inhibitors and chemotherapeutics is a promising approach for improving the efficacy therapy. Nevertheless, problems in pharmacokinetics, toxicity solubility limit application inhibitors. Herein, we developed novel all-in-one hybrid nanoparticle system overcome MDR doxorubicin (DOX)-resistant breast cancer. First, folic...
Abstract Background Functional status of T cells determines the responsiveness cancer patients to immunotherapeutic interventions. Even though cell‐mediated immunity is inaugurated in tumor‐adjacent lymph nodes, peripheral blood has been routinely sampled for testing immunological assays. The purpose this study determine immune checkpoint molecule expression and exhaustion‐related phenotype cytotoxic regional nodes from breast patients. Patients methods Multicolor immunophenotyping was used...
This study evaluates the functional capacity of CD4+ and CD8+ terminally-differentiated effector (TEMRA), central memory (TCM), (TEM) cells obtained from volunteers vaccinated with an aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac). The were followed for T cell immune responses following termination a randomized phase III clinical trial. Seven days four months after second dose vaccine, subsets collected stimulated by autologous monocyte-derived dendritic (mDCs)...
Depending on the microenvironment conditions, macrophages display phenotypic and functional heterogeneity. This study characterized programmed cell death-ligand 2 (PD-L2)-expressing macrophage-like cells drained from surgical wound zones, investigated their influence helper T (Th) responses. Although all CD14+ myeloid possessed features, CD206+ CD163+ constituted a specific subpopulation with high PD-L2 expression. There was modest correlation between levels amount of interferon (IFN)-γ in...
Tumor cells benefit from some certain signals, which are referred to as “immune checkpoints”, escape immune-mediated destruction. With that in mind, it is believed the blockade of these points, such programmed cell death Ligand-1 (PD-L1) and 1 (PD-1), can restore an adaptative immune response against tumoral cells. In this study, we have designed synthesized novel peptidomimetics with a 2-aminobenzathiazole scaffold, targets PD-1/PDL-1 pathway. viability assay, was found compounds decreased...
Generating memory T cell responses besides humoral immune is essential when it comes to the efficacy of a vaccine. In this study, presence after aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac) in seronegative and seropositive elderly individuals were examined. CD4+ CD8+ proliferation IFN-γ production capacities evaluated. Additionally, clinical frailty scale (CFS) FRAIL scales scored. more prominent than cells. individuals, 80% them had IFN-γ, whereas 50% all...