A5090594476- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- Antibiotics Pharmacokinetics and Efficacy
- HIV, Drug Use, Sexual Risk
- Bacterial Infections and Vaccines
- Nosocomial Infections in ICU
- HIV/AIDS Research and Interventions
- Hematological disorders and diagnostics
- Pneumocystis jirovecii pneumonia detection and treatment
- Long-Term Effects of COVID-19
- Infective Endocarditis Diagnosis and Management
- Urinary Tract Infections Management
- Hepatitis C virus research
- Tuberculosis Research and Epidemiology
- HIV-related health complications and treatments
- Healthcare cost, quality, practices
Hacettepe University
2016-2025
Amsterdam University Medical Centers
2023-2024
Vrije Universiteit Amsterdam
2023-2024
Cancer Center Amsterdam
2023-2024
Ankara Onkoloji Eğitim ve Araştırma Hastanesi
2023-2024
Suleyman Demirel University
2024
Office of Infectious Diseases
1999-2023
Hacettepe University Hospital
2009-2023
Turkish Society of Cardiology
2019-2023
Leiden University Medical Center
2023
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the resulting disease 2019 (Covid-19) have afflicted tens of millions people in a worldwide pandemic. Safe effective vaccines are needed urgently.MethodsIn an ongoing multinational, placebo-controlled, observer-blinded, pivotal efficacy trial, we randomly assigned persons 16 years age or older 1:1 ratio to receive two doses, 21 days apart, either placebo BNT162b2 vaccine candidate (30 μg per dose). is lipid...
BNT162b2 is a lipid nanoparticle-formulated, nucleoside-modified RNA vaccine encoding prefusion-stabilized, membrane-anchored severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) full-length spike protein. highly efficacious against disease 2019 (Covid-19) and currently approved, conditionally or authorized for emergency use worldwide. At the time of initial authorization, data beyond months after vaccination were unavailable.In an ongoing, placebo-controlled, observer-blinded,...
COVID-19 (Coronavirus disease of 2019) is an infectious outbreak later on declared as a pandemic, caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). It spreads very rapidly and can result in severe failure. The clinical studies have shown that advanced age chronic diseases increase risk infection. However, influence blood groups infection its outcome remains to be confirmed. aim this study investigate whether there exists relationship between patients outcomes
ABSTRACT Background BNT162b2 is a lipid nanoparticle-formulated, nucleoside-modified RNA vaccine encoding prefusion-stabilized, membrane-anchored SARS-CoV-2 full-length spike protein. highly efficacious against COVID-19 and currently authorized for emergency use or conditional approval worldwide. At the time of authorization, data beyond 2 months post-vaccination were unavailable. Methods In an ongoing, placebo-controlled, observer-blinded, multinational, pivotal efficacy study, 44,165...
A polymerase chain reaction (PCR)-based test was developed for the detection of mecA in staphylococci. To facilitate this process, a rapid cell lysis procedure established release DNA from staphylococcal strains. Primers based on sequence gene Staphylococcus aureus were used PCRs to screen presence total 98 isolates. Fifty-one isolates positive (17 S. strains and 34 coagulase-negative staphylococci including epidermidis, haemolyticus, simulans). Results obtained with generally consistent...
To estimate the proportion of methicillin-resistant Staphylococcus aureus (MRSA) isolates from humans that were sequence type (ST) 398, we surveyed 24 laboratories in 17 countries Europe 2007. Livestock-associated MRSA ST398 accounted for only a small humans; most Netherlands, Belgium, Denmark, and Austria.
Background: In May 2022, the monkeypox virus outbreak in multiple countries on various continents marked a potential resurgence of disease as global health issue. Considering crucial role physicians mitigating outbreak, we sought to evaluate physicians’ knowledge, attitude, concerns, and vaccine acceptance for monkeypox, shadow COVID-19 pandemic. Methods: A large-scale, cross-sectional survey was conducted among 283 between 20 August−2 September Turkey. The participants’ sociodemographic...
Abstract Background Baricitinib has shown efficacy in hospitalized patients with COVID-19, but no placebo-controlled trials have focused specifically on severe/critical COVID, including vaccinated participants. Methods Bari-SolidAct is a phase-3, multicentre, randomised, double-blind, trial, enrolling participants from June 3, 2021 to March 7, 2022, stopped prematurely for external evidence. Patients COVID-19 were randomised 4 mg once daily or placebo, added standard of care. The primary...
Quinolones have been reported to be active against Brucella species in vitro. In this prospective randomized study, the efficacy and safety of combination ofloxacin plus rifampin were compared with doxycycline rifampin, both combinations administered for a 6-week period treatment brucellosis. Sixty-one patients enrolled 49 had blood or bone marrow cultures positive melitensis. Thirty received 200 mg 600 once daily, 31 treated 400 daily 6 weeks. Nine each group complications disease. There...
To assess the total systemic antiviral use in Europe and to identify substances most commonly used. Within European Surveillance of Antimicrobial Consumption (ESAC; www.esac.ua.ac.be), using anatomical therapeutic chemical (ATC) classification defined daily dose (DDD) measurement unit, data on (out- inpatient) (ATC J05), aggregated at level active substance, were collected for 2008, was expressed DDD (WHO ATC/DDD, version 2010) per 1000 inhabitants day (DID). Antiviral grouped according...
ABSTRACT No data on whether brucellar meningitis or meningoencephalitis can be treated with oral antibiotics an intravenous extended-spectrum cephalosporin, namely, ceftriaxone, which does not accumulate in phagocytes, should added to the regimen exist literature. The aim of a study conducted Istanbul, Turkey, was compare efficacy and tolerability ceftriaxone-based antibiotic treatment regimens those protocol patients these conditions. This retrospective enrolled 215 adult 28 health care...
As of March 2021, COVID-19 has claimed the lives more than 2.7 million people worldwide. Vaccination started in most countries around world. In this study, we estimated cost-effectiveness strategies for vaccination Turkey compared to a baseline absence and imposed measures by using an enhanced SIRD (Susceptible, Infectious, Recovered, Death) model various scenarios first year after vaccination. The results showed that is cost-effective from health care perspective, with incremental ratio...
The coronavirus disease 2019 (COVID-19) pandemic continues to wreak havoc on lives and ravage the world. Several vaccines have been approved for use against COVID-19; however, there may be hesitancy negative perceptions towards vaccination, which reduce willingness vaccinated. Further, studies assessing current perception toward COVID-19 vaccination are scarce. This study aimed assess community knowledge, attitudes, regarding among general population of Turkey.A cross-sectional survey was...
Foot infections and their sequelae are among the most common severe complications of diabetes mellitus. As diabetic patients with foot develop osteomyelitis may progress to amputation, early diagnosis is critical.We compared diagnostic values labelled leucocyte scanning Tc(99)m, magnetic resonance imaging (MRI) microbiological examination bone tissue specimens histopathology, definitive procedure. Thirty-one lesions were enrolled in study histopathological was performed all. Patients had...