A5005231071- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Respiratory and Cough-Related Research
- Patient Satisfaction in Healthcare
- Respiratory viral infections research
- Influenza Virus Research Studies
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- Emergency and Acute Care Studies
- COVID-19 Clinical Research Studies
- Healthcare Systems and Technology
- Patient-Provider Communication in Healthcare
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Asthma and respiratory diseases
- COVID-19 and Mental Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammatory Bowel Disease
- Clinical Reasoning and Diagnostic Skills
- Gut microbiota and health
- Healthcare Policy and Management
- Pharmaceutical studies and practices
University of Antwerp
2016-2025
Infectious Diseases Institute
2008-2025
Gouverneur Kinsbergencentrum
2019-2022
RWTH Aachen University
2022
KU Leuven
2005-2021
University of York
2021
University of Maryland, College Park
2021
Geneeskundige en Gezondheidsdienst
2020
Erasmus MC
2019-2020
University of Southampton
2011-2019
<h3>Objective</h3> Resistance to antibiotics is the major cause of treatment failure <i>Helicobacter pylori</i> infection. A study was conducted assess prospectively antibacterial resistance rates <i>H in Europe and link between outpatient antibiotic use levels different countries. <h3>Design</h3> Primary were determined from April 2008 June 2009 18 European Data on yearly cumulative over several years systemic agents ambulatory care for period 2001–8 expressed Defined Daily Doses (DDD) per...
<h3>Background</h3> In 2007, ESAC (http://www.esac.ua.ac.be) published a set of 12 valid drug-specific quality indicators for outpatient antibiotic use in Europe. this study, the authors aimed to develop evidence-based disease-specific prescribing <h3>Methods</h3> Two meetings were convened produce list which conform internationally agreed recommendations, building on similar development indicators, and collaboration with CHAMP HAPPY AUDIT. 62 experts asked complete two scoring rounds...
Background: The ESAC project, granted by DG SANCO of the European Commission, is an international network surveillance systems, aiming to collect comparable and reliable data on antibiotic use in Europe. Data outpatient were collected from 34 countries using ATC/DDD methodology. Methods: For period 1997–2003, systemic antibiotics aggregated at level active substance expressed DDD (WHO, version 2004) per 1000 inhabitants day (DID). Outpatient (ATC J01) 25 countries, able deliver valid data,...
To describe variation in antibiotic prescribing for acute cough contrasting European settings and the impact on recovery.Cross sectional observational study with clinicians from 14 primary care research networks 13 countries who recorded symptoms presentation management. Patients followed up 28 days patient diaries.Primary care.Adults a new or worsening clinical suggestive of lower respiratory tract infection.Prescribing antibiotics by total symptom severity scores over time.3402 patients...
To describe total outpatient systemic antibiotic use in Europe from 1997 to 2009 and analyse statistically trends of composition over time.For the period 1997-2009, data on antibiotics aggregated at level active substance were collected expressed defined daily doses (WHO, version 2011) packages per 1000 inhabitants day (DID PID, respectively). Outpatient (ATC J01) DID 33 European countries able deliver valid was analysed using longitudinal compositional analyses.Total varied by a factor 3.8...
Lower-respiratory-tract infection is one of the most common acute illnesses managed in primary care. Few placebo-controlled studies antibiotics have been done, and overall effectiveness (particularly subgroups such as older people) debated. We aimed to compare benefits harms amoxicillin for lower-respiratory-tract with those placebo both patients aged 60 years or older.Patients than 18 infections (cough ≤28 days' duration) whom pneumonia was not suspected were randomly assigned (1:1) either...
Objective Our aim was to prospectively assess the antibiotic resistance rates in Helicobacter pylori strains Europe 2018 and study link between consumption community H. levels different countries. Design The proportion of primary cases their corresponding risk factors were investigated 24 centres from 18 European countries according a standardised protocol. Data on collected for period 2008–2017. data assessed using generalised linear mixed models. model with best fit selected by means...
<b>Objectives</b> To quantify the diagnostic accuracy of selected inflammatory markers in addition to symptoms and signs for predicting pneumonia derive a tool. <b>Design</b> Diagnostic study performed between 2007 2010. Participants had their history taken, underwent physical examination measurement C reactive protein (CRP) procalcitonin venous blood on day they first consulted, chest radiography within seven days. <b>Setting</b> Primary care centres 12 European countries....
<h3>Background and objective:</h3> Indicators to measure the quality of healthcare are increasingly used by professionals policy makers. In context increasing antimicrobial resistance, this study aimed develop valid drug-specific indicators for outpatient antibiotic use in Europe, derived from European Surveillance Antimicrobial Consumption (ESAC) data. <h3>Methods:</h3> 27 experts (15 countries), a Science Foundation workshop, built on expertise within Drug Utilisation Research Group,...
The European Surveillance of Antimicrobial Consumption (ESAC) project collects data on antibacterial use in Europe, applying the Anatomic Therapeutic Chemical classification system and defined daily dose methodology, as recommended by World Health Organization. Comparable for United States have been collected from IMS Health. sales data, processed according to ESAC suggest that outpatient is high (only 3 27 countries used more) mainly characterized a shift towards newer antibiotics.
BackgroundData on 13 years (1997–2009) of outpatient penicillin use were collected from 33 European countries within the Surveillance Antimicrobial Consumption (ESAC) project and analysed in detail.
Outpatients with acute cough who expect, hope for or ask antibiotics may be more unwell, benefit from antibiotic treatment, and satisfied care when they are prescribed antibiotics. Clinicians not accurately identify those patients.To explore whether patient views (expecting, hoping asking antibiotics) associated illness presentation resolution, perceived by clinicians, the association of all these factors prescribing satisfaction care.Prospective observational study 3402 adult patients...
Mixed methods are commonly used in health services research; however, data not often integrated to explore complementarity of findings. A triangulation protocol is one approach integrating such data. retrospective was carried out on mixed collected as part a process evaluation trial. The multi-country randomised controlled trial found that web-based training communication skills (including use patient booklet) and the C-reactive protein (CRP) point-of-care test decreased antibiotic...
Background Respiratory syncytial virus (RSV) infection in older adults is recognised as an important health issue. We aimed to assess the community burden of RSV Europe aged ≥60 years. Methods This international, prospective, observational cohort study part work by REspiratory Syncytial Consortium EUrope (RESCEU). Participants were recruited through general practitioners' (GPs) offices before two independent seasons. reported weekly about symptoms acute respiratory tract (ARTI) during one...