A5031255875- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Viral gastroenteritis research and epidemiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Influenza Virus Research Studies
- Antifungal resistance and susceptibility
- Parasitic Infections and Diagnostics
- Advanced Biosensing Techniques and Applications
- Cystic Fibrosis Research Advances
- Energy Harvesting in Wireless Networks
- Urinary Tract Infections Management
- Shoulder Injury and Treatment
- Pediatric Urology and Nephrology Studies
- Mycotoxins in Agriculture and Food
- Trauma Management and Diagnosis
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Asthma and respiratory diseases
- Fungal Infections and Studies
- Shoulder and Clavicle Injuries
- Probiotics and Fermented Foods
- Gut microbiota and health
Amsterdam University Medical Centers
2023-2025
University Medical Center Utrecht
2013-2024
Wilhelmina Children's Hospital
2019-2024
University of Amsterdam
2023-2024
Jeroen Bosch Ziekenhuis
2024
Netherlands Organisation for Health Research and Development
2015
Abbott (Netherlands)
2015
Background Respiratory syncytial virus (RSV) infection in older adults is recognised as an important health issue. We aimed to assess the community burden of RSV Europe aged ≥60 years. Methods This international, prospective, observational cohort study part work by REspiratory Syncytial Consortium EUrope (RESCEU). Participants were recruited through general practitioners' (GPs) offices before two independent seasons. reported weekly about symptoms acute respiratory tract (ARTI) during one...
Abstract Rationale Candidozyma auris (formerly Candida ) is a globally emerging potentially multi-drug resistant human pathogenic yeast. To detect C. we aimed to compare different culture-, and molecular-based methods. Methods Rectal swabs routinely collected in clinical care were spiked with concentrations of . Co-infection/colonization was mimicked by spiking part these samples other species. Spiked materials cultured at 37°C or 42°C using CHROMagar CandidaPlus plates. In parallel,...
Respiratory syncytial virus (RSV) surveillance is heavily dependent on the influenza-like illness (ILI) case definition from World Health Organization (WHO). Because ILI includes fever in its syndromic definition, ability to accurately identify acute respiratory tract infections (ARTI) caused by RSV older adults uncertain.The accuracy of WHO and a modified (requiring only self-reported fever) definitions identifying patients with PCR-confirmed RSV-ARTI was evaluated community-dwelling (≥60...
Abstract Background Respiratory syncytial virus (RSV) and influenza infections result in a considerable mortality morbidity among the aging population globally. Influenza vaccination for older adults before seasonal epidemic has been evaluated to be cost-effective many countries. Interventions against RSV are pipeline, evaluating their cost-effectiveness is crucial decision making. To inform such evaluations, our aim was estimate average costs health-related quality of life (HRQoL) with...
ABSTRACT Background Respiratory syncytial virus can cause severe disease in the older adult population. Three vaccines for RSV are currently market approved but risk of RSV‐hospitalization (older) adults from a community level remains elusive. We aimed to estimate and characterize patients that end up hospital. Methods manually analyzed records aged ≥ 20 with RSV‐infection between 2022 2024 three hospitals Netherlands. These implemented routine RSV‐testing at emergency departments. Using...
Respiratory syncytial virus (RSV) causes significant morbidity and mortality in infants worldwide. Although prematurity cardiopulmonary disease are risk factors for severe disease, the majority of hospitalized with RSV previously healthy. Various vaccines therapeutics under development expected to be available near future. To inform use these new therapeutics, it is necessary determine burden Europe. We will prospectively follow-up a birth cohort obtain incidence data on acute respiratory...
Abstract Background Respiratory syncytial virus (RSV) causes a substantial burden in older adults. Viral load RSV-infected adults is generally lower compared to young children, which could result suboptimal sensitivity of RSV diagnostics. Although the Xpert® Xpress Flu/RSV assay has been used routine clinical care, its diagnose infection largely unknown. We aimed compare performance with real-time reverse-transcription polymerase chain reaction (RT-PCR) home-dwelling (≥60 years age). Methods...
Abstract Background Recurrent wheezing in young infants has a high prevalence, influences quality of life, and generates substantial health care costs. We previously showed that respiratory syncytial virus infection is an important mechanism recurrent moderate preterm infants. aimed to provide population‐attributable risks ( PAR ) risk factors for during the first year life otherwise healthy Methods RISK multicentre prospective birth cohort study 4424 born at 32–35 weeks gestation. estimated...
Abstract Background Knowledge about how older adults get a respiratory infection is crucial for planning preventive strategies. We aimed to determine contact with young children living outside of the household affects risk acute tract infections (ARTI) in community-dwelling adults. Methods This study part European RESCEU adult study. Weekly surveillance was performed detect ARTI throughout 2 winter seasons (2017-2018, 2018-2019). Child exposure, defined as having regular under 5 subject’s...
Abstract Background Urinary tract infections are responsible for a significant worldwide disease burden. Performing urine culture is time consuming and labor intensive. Urine flow cytometry might provide quick reliable method to screen urinary infection. Methods We analyzed routinely collected samples received between 2020 2022 from both inpatients outpatients. The UF‐4000 cytometer was implemented with an optimal threshold positivity of ≥100 bacteria/μL. thereafter validated the prognostic...
Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants. Early detection RSV can optimize clinical management and minimize use antibiotics. BinaxNOW (BN) rapid antigen test that widely used. We aimed to validate the sensitivity BN hospitalized nonhospitalized infants against gold standard molecular diagnosis.We evaluated performance with acute respiratory tract infections different degrees disease severity. Diagnostic accuracy results were compared diagnosis as...
Background Because diagnosing asthma in school-aged children is challenging, a variety of proxies for are used clinical practice and research settings as indicators this disease. We aimed to provide insight into the agreement between various based on parental report, medical diagnosis spirometry. Methods Children from WHISTLER birth cohort performed spirometry were followed up with ISAAC (International Study Asthma Allergies Childhood) questionnaires about at 5 8 years age. Medical data...
After having traveled to California in 2017, a 26-year old Dutch man presented 2020 with persisting cough and shortness of breath. Radiology showed cystic bronchiectasis peri-bronchial consolidation his right upper lobe. Laboratory studies August 2021 an increased total IgE, specific
Respiratory syncytial virus (RSV) causes acute respiratory tract infection (ARTI) and reinfects adults throughout life, posing a risk for hospitalization in older (>60 years) with frailty comorbidities.
ABSTRACT Background Respiratory syncytial virus can cause severe disease in the older adult population. Three vaccines for RSV are currently market approved but risk of RSV-hospitalization (older) adults from a community level remains elusive. We aimed to estimate and characterize patients that end up hospital. Methods manually analyzed records aged ≥20 with RSV-infection between 2022-2024 three hospitals Netherlands. These implemented routine RSV-testing at emergency departments. Using...