A5016002845- Infectious Diseases and Tuberculosis
- Bacterial Infections and Vaccines
- Hepatitis B Virus Studies
- Antimicrobial Resistance in Staphylococcus
- Hepatitis C virus research
- Burkholderia infections and melioidosis
- Brucella: diagnosis, epidemiology, treatment
- Antibiotic Resistance in Bacteria
- Streptococcal Infections and Treatments
- HIV/AIDS drug development and treatment
- Orthopedic Infections and Treatments
- Antibiotic Use and Resistance
- HIV/AIDS Research and Interventions
- Hepatitis Viruses Studies and Epidemiology
- Viral Infections and Vectors
- Bacterial Identification and Susceptibility Testing
- HIV Research and Treatment
- Urinary Tract Infections Management
- Nosocomial Infections in ICU
- Tuberculosis Research and Epidemiology
- HIV, Drug Use, Sexual Risk
- Syphilis Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Malaria Research and Control
Haydarpaşa Numune Eğitim ve Araştırma Hastanesi
2012-2022
Sağlık Bilimleri Üniversitesi
2019-2022
Sivas State Hospital
2019
<h2>Abstract</h2><h3>Objectives</h3> We described the clinical outcomes of diabetic patients who had foot infections with multidrug resistant organisms. <h3>Methods</h3> included (DFI) from 19 centers, between May 2011 and December 2015. Infection was defined according to IDSA DFI guidelines. Patients severe infection, complicated moderate infection were hospitalized. The followed-up for 6 months after discharge. <h3>Results</h3> In total, 791 included, 531(67%) male, median age 62 (19–90)....
Brucellosis is a zoonotic infection and has endemic characteristics. Neurobrucellosis an uncommon complication of this infection. The aim study was to present unusual clinical manifestations discuss the management outcome series 18 neurobrucellosis cases. Initial consist pseudotumor cerebri in one case, white matter lesions demyelinating syndrome three cases, intracranial granuloma transverse myelitis two sagittal sinus thrombosis spinal arachnoiditis vasculitis addition meningitis all...
ABSTRACT No data on whether brucellar meningitis or meningoencephalitis can be treated with oral antibiotics an intravenous extended-spectrum cephalosporin, namely, ceftriaxone, which does not accumulate in phagocytes, should added to the regimen exist literature. The aim of a study conducted Istanbul, Turkey, was compare efficacy and tolerability ceftriaxone-based antibiotic treatment regimens those protocol patients these conditions. This retrospective enrolled 215 adult 28 health care...
We aimed to investigate the predictors for limb loss among patients with diabetes who have complicated skin/soft-tissue infections. In this observational study, consecutive diabetic foot infection (DFI) from 17 centres in Turkey, between May 2011 and 2013 were included. The Turkish DFI Working Group performed study. Predictors of investigated by multivariate analysis. total, 455 Median age was 61 years, 68% male, 65% hospitalized, 52% had used antibiotics within last month, 121 (27%)...
Objective: Treponema pallidum and HIV are transmitted frequently through sexual contact, these agents with epidemiological similarities co-infect the same host. The current number of HIV-infected cases in Turkey is increasing. For this reason, we aimed to reveal characteristics syphilis HIV/AIDS cases. Methods: A retrospective longitudinal cohort study was performed, patients were followed up at 24 clinics 16 cities from all seven regions between January 2010 April 2018. We examined...
Background: Nosocomial meningitis is a rare complication following neurosurgical procedures and associated with high morbidity mortality. Aim: The aim of this study was to describe the clinical characteristics risk factors mortality in patients who developed nosocomial operations. Setting design: Tertiary care hospital an observational study. Materials Methods: subjects included 2265 underwent various operations during 2003-05. diagnosis based on Center for Disease Control criteria....
Hepatitis A is a widespread infectious disease. The prevalence of the disease closely related to socioeconomic status (SES) and environmental factors. Understanding its essential for instituting appropriate precautions. aim this study was determine hepatitis evaluate associated demographic features in children young adults Istanbul. In total, 630 individuals between ages 5-24 were included study. They classified into four age groups (5-9, 10-14, 15-19 20-24 years). seropositivity whole...
Investigational approaches based on genome-wide association studies have proven useful in identifying genetic predictors for many diseases, including susceptibility to chronic hepatitis B and C. In these studies, the majority of variants that shown a positive been identified genes involved immune response. this study IFN-γ, IFNGR-1, IRF-1 were analyzed their role development C Turkish population.Polymorphic (-410, -388), IFNGR-1 (-56, -611), IFN-γ (+874) total 400 individuals: 100 patients,...
The identification of microorganisms causing ventilator-associated pneumonia (VAP) is important for formulating appropriate therapies. In this study, we report the incidence, etiology, and antibiotic resistance patterns Gram-negative isolated from patients diagnosed with VAP in our medical-surgical intensive care unit (ICU) during years 2004-2006. was by using clinical criteria Centers Disease Control Prevention. Antibiotic were defined standard methods. incidence rate 22.6/1,000 ventilator...
Central nervous system involvement is a rare but serious manifestation of brucellosis. We present an unusual case neurobrucellosis with transient ischemic attack, intracerebral vasculopathy granulomas, seizures, and paralysis sixth seventh cranial nerves. A 17-year-old Caucasian man presented nausea vomiting, headache, double vision he gave history weakness in the left arm, speech disturbance imbalance. Physical examination revealed fever, doubtful neck stiffness abducens nerve paralysis. An...
Brucellosis is a zoonotic infection and has endemic characteristics. Neurobrucellosis an uncommon complication of this infection. The aim study was to present unusual clinical manifestations discuss the management outcome series 18 neurobrucellosis cases. Initial consist pseudotumor cerebri in one case, white matter lesions demyelinating syndrome three cases, intracranial granuloma transverse myelitis two sagittal sinus thrombosis spinal arachnoiditis vasculitis addition meningitis all...
The aim of the present study was to determine rate device-associated infection (DAI) and change in profiles antimicrobial resistance patterns causative microorganisms a medical-surgical intensive care unit (ICU), as well evaluate effect new nationwide hospital control program (NHICP), which has been implemented Turkey. In this study, 5,772 patients that were hospitalized for total 43,658 days acquired 1,321 DAIs, with an overall 30.2% per 1,000 ICU days. Between 2004 (before NHICP) 2010,...
Tuberculous meningitis (TBM) caused by Mycobacterium tuberculosis resistant to antituberculosis drugs is an increasingly common clinical problem. This study aimed evaluate drug resistance profiles of TBM isolates in adult patients nine European countries involving 32 centers provide insight into the empiric treatment TBM. was cultured from cerebrospinal fluid (CSF) 142 and tested for susceptibility first-line drugs, streptomycin (SM), isoniazid (INH), rifampicin (RIF) ethambutol (EMB)....
HIV-1 replication is rapid and highly error-prone. Transmission of a drug-resistant strain possible occurs within the HIV-1-infected population. In this study, we aimed to determine prevalence transmitted drug resistance mutations (TDRMs) in 1,306 newly diagnosed untreated patients from 21 cities across six regions Turkey between 2010 2015. TDRMs were identified according criteria provided by World Health Organization's 2009 list surveillance mutations. The TDRM was 10.1% (133/1,306) Turkey....
The incidence of drug-resistant pathogens differs greatly between countries according to differences in the usage antibiotics. purpose this study was investigate phenotypic resistance 321 methicillin Staphylococcus aureus (MRSA) and 195 susceptible S. (MSSA) a total 516 strains macrolide, lincosamide, streptogramin B (MLS B), ketolid, linezolid. Disk diffusion method applied determine MLS phenotype susceptibility different antibiotic agents. It found that 54.6% isolates were resistant...
The incidence of drug-resistant pathogens differs greatly between countries according to differences in the usage antibiotics. purpose this study was investigate phenotypic resistance 321 methicillin Staphylococcus aureus (MRSA) and 195 susceptible S. (MSSA) a total 516 strains macrolide, lincosamide, streptogramin B (MLSB), ketolid, linezolid. Disk diffusion method applied determine MLSB phenotype susceptibility different antibiotic agents. It found that 54.6% isolates were resistant...
Background: Broad-spectrum empirical antimicrobials are frequently prescribed for patients with coronavirus disease 2019 (COVID-19) despite the lack of evidence bacterial coinfection.Aims: We aimed to cross-sectionally determine frequency antibiotics use, type prescribed, and factors influencing use in hospitalized COVID-19 confirmed by polymerase chain reaction. Study Design:The study was a national, multicenter, retrospective, single-day point prevalence study.Methods: This singleday...
The aim of this study was to determine the incidence, etiology and risk factors for mortality patients with nosocomial candidemia.This observational performed at Haydarpasa Numune Training Research Hospital, a tertiary care hospital 750 beds, between years 2004 2007. Fifty defined cases bloodstream infection caused by Candida species were included in study. All demographic, microbiological clinical records each patient collected using standardized form. Blood culture automated blood system,...