A5060795981- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Bacterial Infections and Vaccines
- Antimicrobial Resistance in Staphylococcus
- Diagnosis and treatment of tuberculosis
- Bacterial biofilms and quorum sensing
- Lung Cancer Diagnosis and Treatment
- Actinomycetales infections and treatment
- Pneumonia and Respiratory Infections
- Infective Endocarditis Diagnosis and Management
- Aquaculture disease management and microbiota
- Infectious Diseases and Mycology
- Antimicrobial Peptides and Activities
- Abdominal Trauma and Injuries
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Peripheral Neuropathies and Disorders
- Appendicitis Diagnosis and Management
- Sarcoidosis and Beryllium Toxicity Research
- Microbial Metabolism and Applications
- Orthopedic Infections and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Electrokinetic Soil Remediation Techniques
- Abdominal Surgery and Complications
University of Belgrade
2001-2020
Czech Academy of Sciences, Institute of Microbiology
2000-2014
Univerzitetski Klinički Centar Srbije
2013
Institut za Reumatologiju
2004-2006
University of Belgrade – Faculty of Medicine
2004
Lund University
1992
ABSTRACT Staphylococcus sciuri is a principally animal-associated bacterial species, but its clinical relevance for humans increasing. Our study aimed to provide the first insight into prevalence of this bacterium in hospital environment. A 3-month surveillance was conducted located Belgrade, Serbia, and 1,028 samples taken from hands medical personnel, devices, various surfaces were screened S. presence. In total, 108 isolates obtained, which resulted relatively high rate colonization...
Tuberculosis remains a major global cause of morbidity and mortality, There is an urgent need for improved bacteriologic diagnosis Mycobacterium tuberculosis infection. Three methods rapid identification M. in sputum samples (direct microscopy, gas chromatography-mass spectrometry [GC-MS], polymerase chain reaction [PCR]), were compared with culture on Lowenstein-Jensen medium. Growth was observed 38 145 samples. Detection acid-fast bacilli by direct microscopy gave sensitivity 66%...
The ability to form biofilms is a recognized trait of Stenotrophomonas maltophilia, but the extent its clinical relevance still unclear. present multicenter prospective study (ANSELM) aims at investigating association between biofilm formation and outcomes S. maltophilia infections. One hundred nine isolates were collected from various geographical origins stratified according their relevance. Biofilm was evaluated by microtiter plate assay correlated with microbiological data associated...
Tuberculous meningitis (TBM) caused by Mycobacterium tuberculosis resistant to antituberculosis drugs is an increasingly common clinical problem. This study aimed evaluate drug resistance profiles of TBM isolates in adult patients nine European countries involving 32 centers provide insight into the empiric treatment TBM. was cultured from cerebrospinal fluid (CSF) 142 and tested for susceptibility first-line drugs, streptomycin (SM), isoniazid (INH), rifampicin (RIF) ethambutol (EMB)....
Abstract Background Tuberculous meningitis (TBM) represents a diagnostic and management challenge to clinicians. The “ Thwaites’ system” “Lancet consensus scoring are utilized differentiate TBM from bacterial but their utility in subacute chronic where is an important consideration unknown. Methods A multicenter retrospective study of adults with meningitis, defined by symptoms greater than 5 days less 30 for (SAM) (CM). “Thwaites’ scores the accuracy sensitivity, specificity, area under...
Actinobacillus actinomycetemcomitans , a constituent of the oral flora, is rare cause brain abscesses. We report case 47‐year‐old male who presented with multiple abscesses due to this organism, presumably originating from his poor dentition. Problems met in isolating and identifying A. suggest that its true rate isolation non‐oral samples may have been underestimated.
Aims: There is no report on the factors affecting resolution of symptoms related to meningitis during treatment tuberculous (TBM). Thus, we examined associated with early therapeutic responses.Materials and Methods: This multicenter study included 507 patients microbiologically confirmed TBM. However, 94 eligible for analysis were in this from 24 centers. Six out died statistical was performed 88 survivors. Early late responder groups compared analysis. P < 0.05 considered show a significant...
In order to gain precise data on the actual epidemiology of tuberculosis (TB) in Belgrade, central Serbia, we conducted molecular epidemiological investigation described herein. IS6110 restriction fragment length polymorphism (RFLP) typing 176 Mycobacterium isolates was performed. These strains were obtained from 48.4% all patients diagnosed with culture-proven pulmonary TB April through September 1998 and May October 1999. Clusters containing identical RFLP patterns assumed have arisen...
The rates of pulmonary colonization and disease due to nontuberculous mycobacteria (NTM) appear be increasing globally, but diversity species recovered as well clinical relevance NTM isolates differ considerably by geographic region. first nationwide study isolation frequency significance in Serbia included all patients with respiratory specimens yielding a positive culture over the six-year period, 2010–2015. We analyzed trends annual (PD) incidence rates, PD cases defined accordance...
Mass mortality of farmed 1 yr old common carp Cyprinus carpio occurred at a farm in April 2022. In addition to high mortality, diseased fish exhibited papillomatous growths on the skin and fins, characteristic pox. To investigate possible viral cause, tissue samples were collected nucleic acid was extracted using standard procedures. pooled sample from gills kidneys, edema virus (CEV) detected by real-time PCR. with growths, cyprinid herpesvirus (CyHV1) conventional PCR targeting conserved...
A retrospective population-based molecular epidemiologic study of multidrug-resistant Mycobacterium tuberculosis complex strains in Serbia (2008-2014) revealed an outbreak TUR genotype a psychiatric hospital starting around 1990. Drug unavailability, poor infection control, and schizophrenia likely fueled acquisition additional resistance bacterial fitness-related mutations over 2 decades.
Between 1960 and 1974 a total of 14 937 patients were treated in 16 German surgical departments for bronchial carcinoma. 70% proved to be inoperable. In 30% the tumour was resected, five-year survival rate those operated on before 1969 being 23%. suitable cases, lobectomy satisfactory radical method resection parallel with pneumonectomy, while operative risk latter twice as high. The decreased by half during period observation. Best results achieved when early stage. prognosis anaplastic...
The new GenoType MTBDRsl assay (Hain Lifescience) detects mutations most frequently associated with resistance to fluoroquinolones (FLQ), aminoglycosides/cyclic peptides (AG/CP), and ethambutol (EMB) thus, enables rapid identification of extensively drug-resistant (XDR) Mycobacterium tuberculosis strains. A set 19 multidrug-resistant (MDR) strains isolated in Serbia 2011 was tested by the conventional drug susceptibility testing (DST). sensitivity specificity were as follows: 100% for both...
Non-tuberculous mycobacteria are rare but important causes of infection in HIV-positive individuals. A 28-year-old male presented with a high fever, non-productive cough, right subcostal pain, splenomegaly, very low CD4 count, elevated C-reactive protein and erythrocyte sedimentation rate, normal white blood cell count. The suspicion tuberculosis (TB) was high, sputum samples were positive for acid-fast bacilli. Standard quadruple anti-TB therapy initiated, once culture the sample revealed...