A5039746879- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Infectious Diseases and Tuberculosis
- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Infections and bacterial resistance
- Pneumocystis jirovecii pneumonia detection and treatment
- Vibrio bacteria research studies
- Infectious Diseases and Mycology
- Radiation Dose and Imaging
- Streptococcal Infections and Treatments
- COVID-19 diagnosis using AI
- Radiology practices and education
- Autoimmune and Inflammatory Disorders
- Leprosy Research and Treatment
- Parasite Biology and Host Interactions
- Bacterial Infections and Vaccines
- COVID-19 and healthcare impacts
- Enterobacteriaceae and Cronobacter Research
- Bacterial Identification and Susceptibility Testing
- Effects of Radiation Exposure
- Immunodeficiency and Autoimmune Disorders
- Respiratory viral infections research
- Lower Extremity Biomechanics and Pathologies
Singapore General Hospital
2009-2023
Sengkang General Hospital
2020-2023
Singapore Institute of Technology
2020-2021
National University of Singapore
2020
SingHealth
2020
Centers for Disease Control and Prevention
2014
Cleveland Foundation
1998
Cleveland Clinic
1998
ABSTRACT Mycobacterium tuberculosis Beijing strains represent targets of special importance for molecular surveillance (TB), especially because they are associated with spread multidrug resistance in some world regions. Standard 24-locus mycobacterial interspersed repetitive-unit–variable-number tandem-repeat (MIRU-VNTR) typing lacks resolution power accurately discriminating closely related clones that often compose strain populations. Therefore, we evaluated a set 7 additional,...
ObjectiveTo compare the incidence of carbapenemase genes in Acinetobacter baumannii between two time periods.
Information on non-tuberculosis mycobacterial (NTM) diseases remains limited in Singapore and other Southeast Asian countries. This study aimed to delineate epidemiological clinical features of pulmonary NTM disease. A retrospective review was performed all isolates identified General Hospital from 2012 2016 using the 2007 ATS/IDSA diagnostic criteria. total 2026 852 patients were identified. M. abscessus-chelonae group (1010, 49.9%) most commonly isolated implicated Pulmonary cases (352,...
Summary We describe three zoonotic streptococcal soft tissue infections resulting from fresh seafood contact. One was a localized thumb infection with Streptococcus iniae in an immunocompetent healthy young male puncture wound crab pincer. The other two were cases of ascending upper limb cellulitis associated bacteraemia mastectomy patients. these caused by S. while the dysgalactiae subsp. , species that has not been previously described as cause infection. Hence when cleaning raw seafood,...
Nontuberculous mycobacteria infection is a growing global concern, but data from Asia are limited. This study aimed to describe the distribution and antibiotic susceptibility profiles of rapidly mycobacterium (RGM) isolates in Singapore. Clinical RGM with tests performed between 2006 2011 were identified using microbiology laboratory databases minimum inhibitory concentrations amikacin, cefoxitin, clarithromycin, ciprofloxacin, doxycycline, imipenem, linezolid, moxifloxacin, sulfamethoxazole...
We reevaluated the BACTEC MGIT 960 antimicrobial susceptibility testing system (MGIT AST) by using 1,112 isolates of Mycobacterium tuberculosis. When results AST were compared with that proportion method Ogawa medium (Ogawa PM), discrepant obtained for 30 strains isoniazid, all resistant but susceptible PM. For 93% produced results, MIC was 0.4 or 0.8 microg/ml, showing resistance Middlebrook agar plates. Furthermore, it also established analyses katG and inhA genes only have a low level...
Gordonia species have been recognized as pathogens in immunocompromised and immunocompetent patients. We report the first case of bacteremia due to bronchialis a diabetic patient with sequestrated lung. Species identification was confirmed mycolic acid analysis by high-performance liquid chromatography sequencing 16S rRNA gene.
ABSTRACT Four carbapenem-resistant Pseudomonas spp. were isolated from patients in Singapore. One putida isolate contained a bla IMP-1 identical to that first described Japan. The sequence of variant fluorescens four silent mutations compared with the original sequence. remaining P. isolates VIM-6 , novel VIM gene variant.
IntroductionWith the current Covid-19 pandemic, general wards have been converted into cohort for patients who are stable and ambulant. A 2-radiographer mobile radiography team is required to perform bedside Chest X-rays (CXR) these patients. Hospital guidelines require both radiographers be in full Personal Protective Equipment (PPE) throughout image acquisition process radiographic unit needs disinfected twice after each case. This affects efficiency of procedure an increase usage limited...
Abstract Background Unfamiliarity with the presentation, diagnostic process, and treatment of cutaneous non‐tuberculous mycobacterium ( NTM ) infection leads to poorer outcomes. We describe our experience managing in a regional hospital Singapore from 2005 2014. Methods Adult patients infections were identified through positive skin tissue cultures this retrospective case series. excluded younger than 21 years age, whose care was transferred another hospital, catheter‐related infections....
The Mycobacteria Growth Indicator Tube (MGIT 960) system was evaluated against Lowenstein-Jensen (LJ) medium and the BACTEC 460 TB for recovery of mycobacteria from 1393 consecutive urine specimens. MGIT had a sensitivity 91.3% [95% confidence interval (CI), 83.2-99.4] when combination LJ used as reference method. mean time positivity 19.3 days 20 days, respectively, while that 35 days.The incidence contamination highest (n=148), followed by 960 (n=81), lowest (n=50). In conclusion,...
ABSTRACT Thirty-six isolates of carbapenem-resistant Pseudomonas aeruginosa were studied. Pulsed-field gel electrophoresis revealed the presence two clones. One clone carried a bla IMP-1 gene identical to that first described in Japan. The other variant containing four silent mutations. isolate with unique pulsed-field pattern contained IMP-7 .
We report the first outbreak of vancomycin-resistant Enterococcus faecium colonization and infection among inpatients in hematology ward an acute tertiary care public hospital Singapore. Two cases bacteremia 4 gastrointestinal carriage were uncovered before implementation strict control measures resulted outbreak.
Abstract Background Nontuberculous mycobacterium ( NTM ) infections are rare in children, with limited published studies. The course of the disease can be variable and there no accepted treatment guidelines for management children. Objective To review a cohort pediatric patients admitted to tertiary hospital Singapore cutaneous infections. Methods A retrospective was performed all children KK Women's Children's Hospital from 2002 2012. Results Sixty‐seven positive cultures various body sites...
A chest X-ray (CXR), taken in full inspiration, is important to ensure pathology the lungs will not be missed. To achieve this, effective communication on breathing instructions for patients crucial. During COVID-19 pandemic, radiographers Sengkang General Hospital (SKH) were challenged when performing CXR whose native language English. Most of these foreign workers living same dormitory which had formed largest cluster Singapore. These residents found it difficult understand and adhere...