A5041438857- Immune cells in cancer
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Dermatological and COVID-19 studies
- Fibroblast Growth Factor Research
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Congenital Anomalies and Fetal Surgery
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Parasitic Infections and Diagnostics
- Cancer-related gene regulation
- Parasitic infections in humans and animals
Hacettepe University Hospital
2014-2023
Science for Life Laboratory
2023
Uppsala University
2023
Institute for Biomedicine
2023
University of Gothenburg
2023
Hacettepe University
2016
Abstract Interferon (IFN)-γ is the major mediator of anti-tumor immune responses; nevertheless, cancer cells use intrigue strategies to alter IFN-γ signaling and avoid elimination. Understanding regulatory mechanisms employed by acute myeloid leukemia (AML) myelodysplastic syndrome (MDS) upon exposure critical for development immunotherapy checkpoint blockade therapy approaches. This study aims explore influence maturation on IFN-γ-induced PD-L1 PD-L2 expression pro-leukemogenic...
Inflammatory mediators released by cancer cells promote the induction of immune suppression and tolerance in myeloid cells. IL-1 receptor–associated kinase-3 (IRAK3) is a pseudokinase that inhibits IL-1/TLR signaling, but its role patients treated with checkpoint blockade (ICB) therapy remains unclear. Using RNA-Seq data from IMvigor210 trial, we found tumors high IRAK3 expressions showed enriched antiinflammatory pathways worse clinical response to ICB therapy. Upon protein deletion...
A possible relationship between cancer and Echinococcus granulosus infection has been postulated. As T cells are critical players in immune responses against both infections malignancies, an experimental model of secondary echinococcosis breast cancer, this study aims to observe the progression determine characters T-cell responses. 4T1 tumour were subcutaneously injected into mammary region, whereas protoscoleces intraperitoneally inoculated mice. Hydatid cysts, tumours metastases...
Certain subtypes of acute myeloid leukemia (AML) in children have inferior outcome, such as AML with translocation t(7;12)(q36;p13) leading to an MNX1::ETV6 fusion along high expression MNX1. We identified the transforming event this and possible ways treatment. Retroviral MNX1 was able induce mice, similar gene pathway enrichment t(7;12) patient data. Importantly, only induced immune incompetent mice using fetal but not adult hematopoietic stem progenitor cells. The restriction capacity...
Inflammatory alterations of the extracellular matrix shape tumor microenvironment and promote all stages carcinogenesis. This study aims to determine impact cellular fibronectin on inflammatory facets tumor-associated macrophages (TAMs) in breast cancer. Cellular (FN) harboring alternatively spliced extra domain A (FN-EDA) was determined be a component produced by triple-negative cancer (TNBC) cells. High levels FN-EDA correlated with poor survival patients. The proinflammatory cytokine...