A5023889029- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Occupational and environmental lung diseases
- Aldose Reductase and Taurine
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Breast Cancer Treatment Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Computational Drug Discovery Methods
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Antimicrobial Peptides and Activities
- Caveolin-1 and cellular processes
- Chronic Kidney Disease and Diabetes
- Multiple and Secondary Primary Cancers
Hacettepe University
2019-2024
Hacettepe University Hospital
2023-2024
Cancer Institute (WIA)
2023-2024
Bilkent University
2017-2023
Eskişehir Osmangazi University
2021
Background: Prognostic biomarkers for cancer have the power to change course of disease if they add value beyond known prognostic factors, can help shape treatment protocols, and are reliable.The aim this study was identify such colon understand molecular mechanisms leading stratifications based on these biomarkers.Methods Findings: We used an in house R script (SSAT) silico discovery stage-independent using two cohorts, GSE17536 GSE17537, that include 177 55 patients, respectively.This...
Despite the availability of various treatment protocols, response to therapy in patients with Acute Myeloid Leukemia (AML) remains largely unpredictable. Transcriptomic profiling studies have thus far revealed presence molecular subtypes AML that are not accounted for by standard clinical parameters or routinely used biomarkers. Such predicted vary chemotherapy targeted therapy. The Renin-Angiotensin System (RAS) is an important group proteins play a critical role regulating blood pressure,...
Glutamine is a non-essential amino acid that critical for cell growth. However, the differential metabolism of l-glutamine in metastatic versus primary colorectal cancer (CRC) has not been evaluated adequately.
Inflammatory alterations of the extracellular matrix shape tumor microenvironment and promote all stages carcinogenesis. This study aims to determine impact cellular fibronectin on inflammatory facets tumor-associated macrophages (TAMs) in breast cancer. Cellular (FN) harboring alternatively spliced extra domain A (FN-EDA) was determined be a component produced by triple-negative cancer (TNBC) cells. High levels FN-EDA correlated with poor survival patients. The proinflammatory cytokine...
AKR1B1 and AKR1B10, members of the aldo-keto reductase family enzymes that participate in polyol pathway aldehyde metabolism, are aberrantly expressed colon cancer. We previously showed high expression (AKR1B1HIGH) was associated with enhanced motility, inflammation poor clinical outcome cancer patients. Using publicly available datasets ex vivo gene analysis (n = 51, Ankara cohort), we have validated our previous silico finding AKR1B1HIGH worse overall survival (OS) compared patients low...
Aims: Molecular heterogeneity of breast cancer results in variation morphology, metastatic potential and response to therapy.We previously showed that cell line sub-groups obtained by a clustering approach using highly variable genes overlapped almost completely with generated drug cytotoxicity-profile based approach.Two distinct populations thus identified were CSC(cancer stem cell)-like non-CSC-like.In this study we asked whether an mRNA gene signature identifying these two types would...
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Known risk factors for this disease are currently insufficient in predicting mortality. In order to better prognosticate patients with PDAC, we identified 20 genes by utilizing publically available high-throughput transcriptomic data from GEO, TCGA and ICGC which associated overall survival event-free survival. A score generated based on expression matrix of these was validated two independent cohorts. We find that...
As in the case of cancer, risk infection increases when host's immune system is not working properly. It has been shown that toxins produced by bacteria responsible for bacterial infections can alter properties cancer cells as well their sensitivity to chemotherapy agents. Staphylococcus aureus (S. aureus) one most prevalent pathogens acute myeloid leukemia (AML) patients and it produces several virulence factors, including Staphylococcal enterotoxin A (SEA) B (SEB). Cytotoxicity, transwell...
Gastric carcinomas consist of a heterogeneous group neoplasms with broad cytological and architectural variations. lymphoid stroma show poor correlation between their histomorphology biological behavior. This contrast causes need for more detailed analysis molecular exploration stroma-rich gastric medullary like features lack glandular differentiation. In this study, we performed retrospective 53 among 654 tumors from surgical resection specimens, all which had no prominent Morphological...
Pancreatic cancer (PCA) is one of the most lethal malignancies worldwide with a 5-year survival rate 9%. Despite advances in field, need for an earlier detection and effective therapies paramount. PCA high heterogeneity suggests that epigenetic alterations play key role tumour development. However, only few biomarkers or therapeutic targets have been identified so far. Here we explored potential distinct DNA methylation signatures as early prognosis PCA. PI3K/AKT-related genes differentially...
Molecular biomarkers that predict disease progression can help identify tumor subtypes and shape treatment plans. In this study, we aimed to robust of prognosis in gastric cancer based on transcriptomic data obtained from primary tumors.Microarray, RNA sequencing, single-cell sequencing-based gene expression tumors were public databases. Freshly frozen (n = 42) matched FFPE (formalin-fixed, paraffin-embedded) 40) tissues a Turkish cohort used for quantitative real-time PCR...
This research paper presents a novel approach to identifying biomarkers that can be used prognosticate patients with triple-negative breast cancer (TNBC) eligible for neoadjuvant therapy. The study utilized survival and RNA sequencing data from cohort of TNBC identified 276 genes whose expression was related in such patients. gene were then classify into two major groups based on the presence or absence Wingless/Integrated-pathway (Wnt-pathway) mesenchymal (Mes) markers (Wnt/Mes). Patients...
Hepatocellular cancer (HCC) is a leading cause of cancer-related mortality worldwide, and chronic hepatitis B virus infection (CHB) has been major risk factor for HCC development. The pathogenesis HBV-related focus revealing the interplay multitude intracellular signaling pathways, yet precise mechanisms their implementations to clinical practice remain be elucidated. This study utilizes publicly available transcriptomic data from livers CHB patients in order identify population with higher...
Background: Claudin 18.2 (CLDN18.2) is a tight junction protein expressed especially in gastric adenocarcinomas. The prognostic and clinicopathologic implications of CLDN18.2 expression currently unknown. Zolbetuximab monoclonal antibody against under investigation as potential treatment for advanced cancer (GC). We aimed to investigate the impact GC on prognosis tumor features large Turkish cohort.
 Methods: Seven tissue microarrays (TMAs) containing 263 cases were constructed....
Abstract Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Known risk factors for this disease are currently insufficient in predicting mortality. The only FDA approved prognostic biomarker PDAC patients CA19-9. This, along with AJCC TNM staging and performance status, considered important indicators clinical practice. In order to better prognosticate PDAC, we identified a novel panel of genes by utilizing publically available microarray RNAseq data tumors from GEO...
The prognosis of malignant pleural mesothelioma (MPM) is poor, with a limited survival time. In this study, we aimed to examine expression levels genes selected from relevant literature and utilize in silico methods determine whose could reflect the patients MPM by ex-vivo validation experiments.The study group consisted 54 treated chemotherapy. Expression 6 - midkine (MDK), syndecan-1 (SDC1), hyaluronan synthase-2 (HAS2), sestrin-1 (SESN1), laminin subunit alpha-4 (LAMA4), fibulin-3 (FBLN3)...
Abstract Breast cancer shows plasticity in terms of classification. Upon drug treatment and metastasis some tumors switch to another subtype leading loss response therapy. In this study, we ask the question which molecular subclasses breast are more switchable upon therapy metastasis. We used silico data classify PAM50 classes before after using gene expression data. Similar analysis was performed for primary their metastatic growth. Our showed that both scenarios shift from one class...
Objective: Stromal cells in the tumor microenvironment (TME) are among main players of carcinogenesis. Cancer-associated fibroblasts (CAFs) residing stroma involved cancer progression through various mechanisms, supporting growth, cellular motility and invasiveness. The discovery markers predicting recurrence risk colorectal (CRC) have led to generation several gene panels, including Coloprint. This study aimed understand impact a CAF-rich CAF-poor TME on performance prognostic Materials...
Replacing equipment and software can improve efficiency allow updates to laboratory procedures, but has the potential introduce changes in established values for a laboratory. Replacement of an electron microscope (EM), fitted with updated digital camera, use new imaging analysis prompted this QA study ensure that equipment, imaging, measurement glomerular basement membrane (GBM) produced data consistent laboratory's range normal width. GBM measurements from 14 randomly selected human renal...
Numerous natural products exhibit antiproliferative activity against cancer cells by modulating various biological pathways. In this study, we investigated the potential use of eight compounds (apigenin, curcumin, epigallocatechin gallate, fisetin, forskolin, procyanidin B2, resveratrol, urolithin A) and two repurposed agents (fulvestrant metformin) as chemotherapy enhancers mesenchymal-to-epithelial (MET) inducers cells. Screening these in colon, breast, pancreatic cell lines revealed...
Background/aim: Cysteine and glycine-rich protein 1 (CSRP1) is involved in the cysteine-rich family a marker of smooth muscle lineages. In colon cancer, expression this gene associated with poor prognosis. study, aim was to reevaluate its prognostic relationship independent cohorts explore potential underlying biological processes that are linked aggressive behavior tumors high CSRP1 expression, such as epithelial-to-mesenchymal transition (EMT), stromal fractions tumor microenvironment,...
Abstract Hepatocellular cancer (HCC) is a leading cause of related mortality worldwide and chronic hepatitis B virus infection (CHB) has been major risk factor for HCC development. Pathogenesis HBV focus revealing the interplay multitude intracellular signaling pathways, yet precise mechanisms their implementations to clinical practice remains be elucidated. This study utilizes publicly available transcriptomic data from livers CHB patients in order identify population with higher-risk...