A5004608949- Multiple Sclerosis Research Studies
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Autoimmune Neurological Disorders and Treatments
- Lung Cancer Research Studies
- Glycosylation and Glycoproteins Research
- Peripheral Neuropathies and Disorders
- Inflammasome and immune disorders
- Diabetes and associated disorders
- RNA regulation and disease
- Monoclonal and Polyclonal Antibodies Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Hepatitis B Virus Studies
- Cancer-related molecular mechanisms research
- Glutathione Transferases and Polymorphisms
- Cardiovascular Disease and Adiposity
- interferon and immune responses
- Endoplasmic Reticulum Stress and Disease
- Migraine and Headache Studies
- Bioactive Compounds and Antitumor Agents
- Redox biology and oxidative stress
- Synthesis and biological activity
- Genomics, phytochemicals, and oxidative stress
- Polyomavirus and related diseases
İzmir University of Economics
2025
Istanbul University
2013-2024
Eskişehir Osmangazi University
2007
Ludwig Cancer Research
2004
Memorial Sloan Kettering Cancer Center
2004
Abstract BACKGROUND Expression of neuroectodermal markers is a key feature small cell lung carcinoma (SCLC). Although immune responses against number these proteins have been associated with paraneoplastic neuronal disease (PND), most patients SCLC anti‐neuroectodermal antibodies in the absence PND. Whether affect clinical outcome critical understanding potential value as cancer vaccine targets well pathogenesis METHODS The authors investigated frequency immunoglobulin G autoantibodies...
Patients with the syndrome of headache neurological deficits and lymphocytosis (HaNDL) typically present recurrent temporary attacks symptoms cerebrospinal fluid lymphocytosis.To identify potential HaNDL-associated antibodies directed against neuronal surface and/or synapse antigens, sera four HaNDL patients controls were screened indirect immunohistochemistry, immunofluorescence, cell-based assay, radioimmunoassay, protein macroarray enzyme-linked immunosorbent assay (ELISA).Although did...
<b><i>Background/Aims:</i></b> To better characterize progressive encephalomyelitis with rigidity and myoclonus (PERM) syndrome identify novel PERM phenotypes. <b><i>Methods:</i></b> The clinical features antibody status of patients were investigated using immunoblots, cell-based assays, RIA, protein macroarray ELISA. <b><i>Results:</i></b> Two supratentorial involvement showed abnormal PET or EEG findings. One patient...
Familial Mediterranean fever (FMF) is associated with more than 70 missense mutations in the MEFV gene. The purpose of this study was to investigate relative expression messenger RNA (mRNA) for gene peripheral blood leukocytes (PBLs) obtained from patients FMF during attacks acute abdominal inflammation as well asymptomatic periods.We studied 16 an attack peritonitis and 17 otherwise healthy individuals who were undergoing surgery because appendicitis. Blood samples collected both groups...
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers. Known risk factors for this disease are currently insufficient in predicting mortality. In order to better prognosticate patients with PDAC, we identified 20 genes by utilizing publically available high-throughput transcriptomic data from GEO, TCGA and ICGC which associated overall survival event-free survival. A score generated based on expression matrix of these was validated two independent cohorts. We find that...
Glutathione S-transferase P1 (GSTP1) plays an important role in cellular protection against oxidative stress and toxic chemicals. Polymorphisms within GSTP1 are associated with alterations enzyme activity, which may lead to development of lung disease cancer. In this study, we aimed investigate the Ile105Val Ala114Val polymorphisms patients small cell cancer (SCLC).GSTP1 polymorphism exon 5 6 were determined by using polymerase chain reaction-restriction fragment length techniques 89 SCLC...
Neurological symptoms (neuro-Behçet's disease; NBD) occur in a fraction of Behçet's disease (BD) patients and often present with parenchymal brain lesions clinical exacerbations. Our aim was to identify genes associated attack remission periods NBD.Microarray analysis performed using peripheral blood mononuclear cell (PBMC) samples obtained during five NBD patients. Expression levels the most significantly up-regulated were measured real-time PCR PBMC 15 20 healthy controls.During attacks,...
11β-HSD-1 expressed in ascending aorta of MS patient with CAD activity and mRNA levels are increased visceral subcutaneous adipose tissues metabolic syndrome subjects.We analyzed expression human epicardial (EA) (AA) patients examined their contribution to the development coronary atherosclerosis.The was evaluated by qRT-PCR EA AA 20 artery disease (metabolic group) 10 non-metabolic without (controls).11β-HSD-1 group (4.1-and 5.5-fold, respectively).A significant positive correlation found...
Anti-SOX2 antibody responses are observed in about 10 to 20% of small cell lung cancer (SCLC) patients. The aim this study was determine whether such reflect a particular pattern SOX2 protein expression the tumor and associates with clinical outcome.Paraffin embedded tissues, obtained from SCLC patients who had no evidence paraneoplastic autoimmune degeneration, were evaluated for by immunohistochemistry both intensity extent staining. Sera same tested autologous antibodies against...
Objectives . In our study we aimed to determine VDR gene polymorphisms in patients with Behçet’s disease (BD) and neuro-Behçet’s (NBD) Turkish population. Methods. PBL obtained from 37 BD, 21 NB, 30 healthy controls were investigated. Genomic DNA was extracted whole blood using the QIAamp Blood Kit. ApaI (rs7975232), FokI (rs2228570), TaqI (rs731236) genotyping performed by real-time polymerase chain reaction SimpleProbe melting-curve analysis. Results. The allelic genotype distributions of...
<b><i>Objective:</i></b> This study was conducted to identify a biomarker for multiple sclerosis (MS) that can be used as predictor of relapse and disability. <b><i>Materials Methods:</i></b> Sera 26 consecutive relapsing-remitting MS (RRMS) patients were screened switch-associated protein 70 (SWAP-70) antibody, which previously identified by macroarray. The serum levels several cytokines, chemokines soluble adhesion molecules related attacks...