A5040826605- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Vitamin C and Antioxidants Research
- Tryptophan and brain disorders
- Vitamin K Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Paraoxonase enzyme and polymorphisms
- Biochemical effects in animals
- Circadian rhythm and melatonin
- Migraine and Headache Studies
- Folate and B Vitamins Research
- Trace Elements in Health
- Renin-Angiotensin System Studies
- DNA Repair Mechanisms
- Biochemical Analysis and Sensing Techniques
- Peripheral Artery Disease Management
- Liver Disease Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Diet and metabolism studies
- Stress Responses and Cortisol
- Pharmacological Effects of Natural Compounds
Istanbul University
2013-2024
Haliç University
2016-2018
Istanbul Yeni Yüzyıl University
2018
Kırklareli University
2016
Neuroscience Institute
2009
Tiroid hastalıkları, tiroid hormonlarının aşırı veya yetersiz salgılanmasından kaynaklanabilen hastalıklardır. Otoimmün tetiklenen ve hipotiroidi ile seyreden Hashimoto tiroidit (HT) de yüksek prelavansa sahip hastalıklarından biridir. Bezin hormon üreritimi metabolik işlevlerini yerine getirebilmesi için birçok eser elemente ihtiyaç duymaktadır. Bu çalışmadaki amacımız HT tanısı almış hastalarda serum element elektrolit profilini incelemektir. amaçla erişkin- hastalar (HT Grubu)...
There is a growing interest in the understanding of possible role DNA repair systems ageing and neurodegenerative diseases after damage observed brain individuals affected by diseases. In light these findings, we investigated whether gene polymorphisms (XRCC1 Arg399Gln, XRCC3 Thr241Met XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, HOGG1 Ser326Cys) account for an increased risk Parkinson's disease (PD).The present analyses are based on 60 case subjects with PD 108 unrelated healthy controls....
Family, twin and adoption studies have provided major evidence for the role of genetics in numerous psychiatric disorders including schizophrenia (SZ) bipolar (BDs). As SZ BD some susceptibility genes common since unaffected first-degree relatives these patients carry a high likelihood genes, we aimed to elucidate angiotensin-converting enzyme (ACE) genetic variants with SZ, their relatives.The study sample comprised 239 184 BD, 284 biological 301 210 healthy controls. The ACE genotypes were...
Introduction Stress is a stimulus that activates the hypothalamic pituitary adrenal (HPA) axis and sympathetic nervous system (SNS). Increased activity of SNS causes to increment or impairment in blood pressure, heart rate, body temperature plasma glucose adrenocorticotrophic hormone (ACTH) levels. Angiotensin II (Ang II), which product renin-angiotensin (RAS), an important factor affecting responses stress. We suggest blockade Ang may be worthwhile prevention treatment diabetes mellitus...
Migraine is a primary headache disorder which involves both genetic and environmental components. Since angiotensin-converting enzyme (ACE) matrix metalloproteinase (MMP) share the same homology, we investigated whether MMP-3 ACE I/D gene variants are involved in migraine risk variant might act combination with patients migraine. This first study to evaluate association between polymorphisms, Genotypes were determined by polymerase chain reaction. The frequencies of 5A5A genotypes D allele...
Introduction: During the course of systemic inflammation, most immune cell types get activated to a certain degree as part of, or contributing to, cascade physiopathological events.Whether for some cells, classically phagocytes innate system, it is clear that direct sensing pathogen-associated molecular patterns leads activation initiating picture not so natural killer (NK) cells.While NK cells have been shown express toll-like receptors (TLR), role these on NKs during inflammation has...
Nitric oxide synthase (eNOS/NOS3) is responsible for the endothelial synthesis of nitric (NO • ). G894T polymorphism leads to amino acid substitution from Glu298Asp that causes lower NOS3 activity and basal NO production in 894T (298Asp) allele carriers compared with GG homozygotes. acts as an antioxidant protecting against Fenton’s reaction which generates highly reactive hydroxyl radicals. Allelic variation may influence individual’s risk laryngeal cancer (LC). In current study we have...
Abstract We investigated the association of PON1 55/192 polymorphisms with type, severity and prognosis stroke oxidative markers. Paraoxonase1 (PON1), Glutathione Reductase (GSH‐Rd) Malondialdehyde (MDA) levels were measured at day 1 5 following onset stroke. Genotypes determined by polymerase chain reaction restriction digestion. The frequencies QQ MM genotypes 192 55, respectively, significantly higher in controls than patients. However, allele R 55 L more frequent patients compared to...
In the literature, few studies have investigated effects of melatonin on energy metabolism in skeletal muscle endotoxemia. We tissue structure, muscle, and antioxidant level rats with divided into 4 groups, control, lipopolysaccharide (LPS) (20 mg/kg, i.p., single dose), (10 three times), + LPS. Melatonin was injected i.p. 30 min before after 2nd 4th hours LPS injection. Antioxidant status determined by glutathione (GSH) measurement blood. Muscle stained using modified Gomori trichrome...
Background Oxidative stress and free radical-induced toxicity have been implicated in the pathophysiology of schizophrenia. In this study, we examined paraoxonase (PON1)-55/192 polymorphisms PON1 activity patients with schizophrenia, first-degree relatives schizophrenic patients, healthy controls. Methods This study consisted 292 participants, 267 unrelated schizophrenia 311 patients. 55 (rs 854560) 192 662) were performed by restriction fragment length polymorphism. Results The frequencies...
We aimed to investigate the effects of melatonin administered before and during endotoxemia on lung tissue rats, cytokine, YKL-40, matrix metalloproteinase (MMP) inhibitor levels, oxidative stress parameters, energy balance. Sepsis was induced with lipopolysaccharide (LPS), cell wall molecule gram negative bacteria. Rats were divided into four groups, Control, LPS (Escherichia coli O127:B8, 20 mg/kg), (10 melatonin+LPS (M+LPS). After injections, tissues samples taken for experimental...
Peripheral vascular disease is an atherosclerotic process. It has been suggested that angiotensin converting enzyme insertion/deletion polymorphism associated with atherosclerosis. The aim of this study was to investigate the role angiotensin-converting in Turkish patients peripheral Western part Turkey. We also investigated relationship between serum activity and distribution genotypes both control group. group consisted 78 disease. 73 healthy adults. Serum activities were higher than those...
Primary objective: The present study was undertaken to evaluate whether enoant, which is rich in polyphenols, has any effect on electroencephalogram (EEG), oxidative stress and inflammation ischemia/reperfusion (I/R) injury.Methods: Ischemia induced by 2-hour occlusion of bilateral common carotid artery. Animals orally received enoant. Group 1 the ischemic control group. 2 treated with enoant 1.25 g kg−1 per day for 15 days after I/R. 3 same concentration as group before 4 sham operation EEG...
OBJECTIVE: We aimed to investigate the effects of exogenous ghrelin on cytokine and levels, oxidant parameters, apoptotic genes in lung tissue during sepsis.BACKGROUND: There was evidence that changes apoptosis are linked with morbidity mortality sepsis.There were scarce studies effect endogenous levels sepsis.METHODS: Male Wistar albino rats 200-250 g separated into four groups; Control, LPS (5 mg/kg), Ghrelin (10 nmol/kg i.v.), LPS+Ghrelin.Tumor necrosis factor-alpha (TNF-α),...