A5073051115- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Sleep and Wakefulness Research
- Autoimmune and Inflammatory Disorders Research
- Ubiquitin and proteasome pathways
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Tryptophan and brain disorders
- Amyotrophic Lateral Sclerosis Research
- Neurogenesis and neuroplasticity mechanisms
- Immune Response and Inflammation
- Cerebrospinal fluid and hydrocephalus
- Prion Diseases and Protein Misfolding
- Genomic variations and chromosomal abnormalities
- Skin and Cellular Biology Research
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Circadian rhythm and melatonin
- Viral Infections and Immunology Research
- T-cell and B-cell Immunology
- RNA regulation and disease
- Neurological diseases and metabolism
- Studies on Chitinases and Chitosanases
Istanbul University
2019-2024
Creative Commons
2021
Haydarpaşa Numune Eğitim ve Araştırma Hastanesi
2021
Neurological symptoms (neuro-Behçet's disease; NBD) occur in a fraction of Behçet's disease (BD) patients and often present with parenchymal brain lesions clinical exacerbations. Our aim was to identify genes associated attack remission periods NBD.Microarray analysis performed using peripheral blood mononuclear cell (PBMC) samples obtained during five NBD patients. Expression levels the most significantly up-regulated were measured real-time PCR PBMC 15 20 healthy controls.During attacks,...
Context/Objective: Clinical disease activity in multiple sclerosis (MS) may manifest as predominant involvement of optic nerves and spinal cord, exemplified by opticospinal (OSMS) often encountered Asian countries. Our aim was to compare the clinical features, neuropsychological profile cytokine/chemokine levels patients with conventional MS (CMS) presenting predominantly cord nerve attacks (MS-SCON).Design: Cross-sectional study.Setting: Outpatient Clinic.Participants: Fourteen MS-SCON...
Abstract Chronic inflammatory demyelinating polyneuropathy (CIDP), a common and treatable autoimmune neuropathy, is frequently misdiagnosed. The aim of this study to evaluate the relationship between immunological markers clinical outcome measures in mixed cohort patients with typical CIDP variants at different disease stages. Twenty-three typical, 16 multifocal five distal were included. Twenty-five sex age-matched healthy controls 12 Charcot–Marie–Tooth type 1A (CMT1A) served as controls....
Ocrelizumab is a CD20-targeting monoclonal antibody used for treatment of multiple sclerosis (MS). Serum and cerebrospinal fluid (CSF) neurofilament light (NFL) chain levels are reduced in MS patients under ocrelizumab indicating preventive action against neuro-axonal degeneration. Our aim, this preliminary study, was to explore the impact on synaptic integrity through assessment neurogranin levels.
Clinical exacerbations characterized with neurological symptoms are observed in around 10% of Behçet's disease (BD) patients and may culminate severe disability. Although certain immunological factors have been associated activity neuro-Behçet's (NBD), biomarkers for monitoring the clinical outcome NBD not properly investigated.Levels neurofilament light chain (NFL), homeobox protein Hox-B3 (HoxB3), YKL-40 were measured cerebrospinal fluid (CSF) samples 23 parenchymal (n = 16) nonparenchymal...
<strong>Objective</strong>: Multiple Sclerosis (MS) is a progresive and an immune mediated inflammatory central nervous disease. The focus of this study was to determine the possible relationship between B cell immunophenotypes related gene expressions in benign MS (BMS) group with disease cognitive processes. <br> <strong>Material Method</strong>: Twenty BMS patients, 16 non-BMS 28 healthy volunteers were included study. Gene expression performed by real-time PCR (RT-PCR). Immunophenotyping...
Objective: We have previously shown altered blood B cells in the first attack samples of clinically isolated syndrome (CIS) patients, who converted to multiple sclerosis (MS). Our aim was investigate levels cell receptor (BCR)-associated genes expression converting CIS (CIS-c) and non-converting patients (CISnc) with a 5-year follow-up. Methods: Seven CIS-c 12 CIS-nc 10 agesex matched healthy donors were enrolled this study. RNA extracted from frozen peripheral subjects that obtained using...
Objective: Multiple Sclerosis (MS) is an autoimmune, demyelinating, and neurological disorder of the central nervous system (CNS).For years, cellular immunity thought to be possible potential mechanism in immunopathogenesis disease; however, nowadays, studies show that humoral has a major part also plays important role.Neuropsychological tests known detect mild, moderate, or severe cognitive impairments occur patients, particularly memory executive functions are affected.Studies showed...
Introduction: Prevision of conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) is required avoid unnecessary use immunomodulating agents and recognize patients with high disease activity. Our aim was evaluate the value phosphorylated neurofilament heavy chain (pNFH, a marker for neuroaxonal degeneration) Cyclic adenosine monophosphate response element-binding protein (cAMP [CREB], neuroregeneration) levels in prediction CIS MS. Methods: Twenty-three consecutively...