A5038440661- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Neuroscience and Neural Engineering
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Nanoparticle-Based Drug Delivery
- Machine Learning in Bioinformatics
- Genetics and Neurodevelopmental Disorders
- CRISPR and Genetic Engineering
- Cell Image Analysis Techniques
- Laser-Ablation Synthesis of Nanoparticles
- Migraine and Headache Studies
- COVID-19 and healthcare impacts
- Anesthesia and Neurotoxicity Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Medicinal Plants and Neuroprotection
- RNA Research and Splicing
- Autoimmune Neurological Disorders and Treatments
- Neurogenetic and Muscular Disorders Research
- Traumatic Brain Injury Research
- Child Nutrition and Feeding Issues
- 3D Printing in Biomedical Research
- Advanced Chemical Sensor Technologies
- Gene expression and cancer classification
Istanbul Medipol University
2012-2024
Van Yüzüncü Yıl Üniversitesi
2011
Abstract Spinal cord injuries are very common worldwide, leading to permanent nerve function loss with devastating effects in the affected patients. The challenges and inadequate results current clinical treatments scientists innovative neural regenerative research. Advances nanoscience tissue engineering have opened new avenues for spinal injury (SCI) treatment. In order designed guidance conduit (NGC) be functionally useful, it must ideal scaffold properties topographic features that...
The axolotl (Ambystoma mexicanum), a neotenic salamander with remarkable regenerative capabilities, serves as key model for studying nervous system regeneration. Despite its potential, the cellular and molecular mechanisms underlying this capacity remain poorly understood, partly due to lack of reliable in vitro models neural cells. In study, we developed novel protocol primary cultures adult telencephalon/pallium, enabling maintenance viable functionally active Using calcium imaging...
Patients with the syndrome of headache neurological deficits and lymphocytosis (HaNDL) typically present recurrent temporary attacks symptoms cerebrospinal fluid lymphocytosis.To identify potential HaNDL-associated antibodies directed against neuronal surface and/or synapse antigens, sera four HaNDL patients controls were screened indirect immunohistochemistry, immunofluorescence, cell-based assay, radioimmunoassay, protein macroarray enzyme-linked immunosorbent assay (ELISA).Although did...
Trauma, vascular events, or neurodegenerative processes can lead to axonal injury and eventual transection (axotomy). Neurons survive axotomy, yet the underlying mechanisms are not fully understood. Excessive water entry into injured neurons poses a particular risk due swelling subsequent death. Using in vitro vivo neurotrauma model systems based on laser surgical nerve cut, we demonstrated that axotomy triggers actomyosin contraction coupled with calpain activity. As consequence, shrink...
G. Öztürk, N. Cengiz, E. Erdoğan, A. Him, K. Oğuz, Yenidünya and Ayşit (2013) Neuropathology Applied Neurobiology 39, 362–376 Two distinct types of dying back axonal degeneration in vitro Aims: In many neurodegenerative diseases following traumas, is a common phenomenon that aggravates the pathology may eventually lead to death affected neurone. We aimed investigate mechanism with an injury model. Methods: cultured adult mouse dorsal root ganglion neurones precise laser beam, cut axons they...
Automated screening systems in conjunction with machine learning-based methods are becoming an essential part of the healthcare for assisting disease diagnosis. Moreover, manually annotating data and hand-crafting features training purposes impractical time-consuming. We propose a segmentation classification-based approach assembling automated system analysis calcium imaging. The method was developed verified using effects IgGs (from Amyotrophic Lateral Sclerosis patients) on (Ca2+)...
Abstract With the development of gold nanorods (AuNRs) for a number biomedical applications, understanding their various biological effects has become important. Surface functionalization AuNRs is attracting increasing attention with regard to toxicity, cellular uptake, localization, therapeutic potential, and biodistribution. The aim study synthesis stable functionalized polyethylenimine (PEI) polyethylene glycol (PEG), multiparametric investigation on dorsal root ganglion (DRG) primary...
Objective: This study aimed to establish a reliable protocol for obtaining healthy and long-lived cortical neurons from newborn mice, providing valuable model studying neuronal function. Materials Methods: Cortical regions of P0 mice were isolated obtained by enzymatic mechanical dissociation. On the seventh day incubation, presence was detected staining with neuron-specific antibodies. Transgenic expressing fluorescent proteins specific neurons, glia oligodendrocytes also used culture....
Aim: Gold nanoparticles (AuNPs) have many biomedical applications due to their unique properties (e.g., chemical stability, optical properties, biocompatibility, easy synthesizability, and multiple functionalizations).This study aimed synthesize two highly monodispersed stable AuNPs of different sizes (AuNP20 AuNP50), modified with polyethyleneimine (PEI) polyethylene glycol (PEG), systematically investigate toxicological effects on histological changes in the organs BALB/c mice.Methods:...
Abstract Trauma, vascular events, or neurodegenerative processes can lead to axonal injury and eventual transection (axotomy). Neurons survive axotomy, yet the underlying mechanisms are not fully understood. Excessive water entry into injured neurons poses a particular risk due swelling subsequent death. Using in vitro vivo neurotrauma model systems based on laser transection, we demonstrated that axotomy triggers actomyosin contraction coupled with calpain activity. As consequence, shrink...
Amaç: Bu araştırmada, üstün zekâlı çocuğu olan annelerin gebelik dönemindeki beslenme alışkanlıklarının araştırılması ve kontrol grubu ile karşılaştırılması amaçlanmıştır. Gereç Yöntemler: Retrospektif tanımlayıcı nitelikteki bu çalışmaya 48'i 46'sı 94 çocuk anne çifti dâhil edilmiştir. Demografik bilgiler, alışkanlıkları fiziksel aktivite durumları anket formu sorgulanmıştır. Bulgular: Üstün zekâ grubundaki çocukların yaş ortalamaları sırasıyla 9,3±1,9 10,3±1,4 yıldır. Annelerin eğitim...
Objectives: Gold nanoparticles are very popular metallic nanomaterials and they have a wide spectrum of biomedical applications. This study was aimed to the production stable monodisperse polyethyleneimine (PEI) polyethylene glycol (PEG) coated gold (AuNP20 AuNP50), investigation their in vivo biochemical effects BALB/c mice. Methods: were synthesized surfaces modified by PEI PEG. All necessary physicochemical characterizations performed. After single high dose i.v. injection (5 mg Au/kg...