A5090133177- AI in cancer detection
- Renal cell carcinoma treatment
- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Urinary and Genital Oncology Studies
- Lung Cancer Treatments and Mutations
- Oral Health Pathology and Treatment
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Fibroblast Growth Factor Research
- Urological Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Silk-based biomaterials and applications
- Sarcoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Laser Applications in Dentistry and Medicine
- Inflammasome and immune disorders
- Meningioma and schwannoma management
- Advanced X-ray and CT Imaging
- Digital Imaging for Blood Diseases
- Lipid metabolism and disorders
- Multiple and Secondary Primary Cancers
Wojskowy Instytut Medycyny Lotniczej
2015-2024
Central Clinical Hospital
2020-2023
Wojskowy Instytut Medyczny
2022
National Academy of Medicine
2012-2020
Ministry of National Defense
2020
Tumor-driven immune suppression is a major barrier to successful immunotherapy in ovarian carcinomas (OvCa). Among various mechanisms responsible for suppression, arginase-1 (ARG1)-carrying small extracellular vesicles (EVs) emerge as important contributors tumor growth and escape from the host system. Here, we report that EVs found ascites plasma of OvCa patients contain ARG1. suppress proliferation CD4+ CD8+ T-cells vitro vivo mouse models. In mice, ARG1-containing are transported draining...
Abstract During the diagnostic workup of lung adenocarcinomas (LAC), pathologists evaluate distinct histological tumor growth patterns. The percentage each pattern on multiple slides bears prognostic significance. To assist with quantification patterns, we constructed a pipeline equipped convolutional neural network (CNN) and soft-voting as decision function to recognize solid, micropapillary, acinar, cribriform non-tumor areas. Slides primary LAC were obtained from Cedars-Sinai Medical...
β-catenin is the key protein in WNT signalling pathway and it forms adherent junctions together with E-cadherin. In ovarian carcinoma, abnormal expression of β-catenin, E-cadherin WNT-1 was observed, but their prognostic predictive role unclear. The aim this study to clarify E-cadherin, advanced epithelial carcinoma (AEOC). determined by immunohistochemistry AEOC. correlation between these proteins progression-free survival (PFS) overall (OS) evaluated. Statistical analyses included...
The aim of the study was to determine prognostic value expression levels biomarkers selected on basis literature: p53, Ki-67, survivin, β-catenin, E-cadherin and N-cadherin in patients with non-muscle invasive bladder cancer. Immunohistochemistry performed sections primary papillary carcinoma removed during transurethral resection tumor 134 patients. β-catenin found all analyzed cases demonstrated 3.73% tissues examined. p53 protein confirmed 96.27% Ki-67 cases. Survivin 95.52% group....
The aim of this study was to evaluate association expression survivin and p53 with the effects neoadjuvant chemotherapy (NAC) in patients advanced ovarian cancer (AOC).We retrospectively evaluated 60 consecutive AOC (International Federation Gynecology Obstetrics stage IIIC-IV) treated NAC. assessed immunohistochemically. median total score equals 2 adopted dichotomize group. positive negative used group.The tumor tissue taken before after NAC a significant difference percentage stained...
Ovarian cancer has one of the highest death/incidence rates and is commonly diagnosed at an advanced stage. In recent WHO classification, new histotypes were classified which respond differently to chemotherapy. The e-standardized synoptic pathology reports offer clinicians essential reliable information. aim our project was develop e-template for standardized reporting ovarian carcinoma [based on checklist College American Pathologists (CAP) WHO/FIGO classification] introduce a uniform...
Skin wounds remain a significant problem for the healthcare system, affecting clinical outcome, patients' quality of life, and financial costs. Reduced wound healing times would improve clinical, economic, social aspects both patients system. has been studied years, but effective therapy that leads to accelerated remains be discovered. This study aimed evaluate potential MELK silencing accelerate healing. A vectorless, transient knockdown gene using siRNA was performed in murine skin model....
The paper presents the automatic method to examine histological Whole Slide Images of hemorrhoids. specimen were stained by Hematoxiline and Eosine, evaluated number vessels, occurrence blood clots hemorrhage. proposed is based on colour deconvolution, mathematical morphology, decision tree classification, region growing operation reconstruction. results algorithm compared with medical expert results, what confirmed efficiency presented algorithm. In 80% cases, vessels correctly detected....
Abstract Introduction After transurethral resection of a bladder tumor, patients frequently have recurrence the disease, thereby requiring adjuvant therapy. Purpose The study aimed to determine prognostic value expression levels p53, Ki-67, and survivin, develop new model for with non-muscle-invasive cancer (NMIBC) after tumor. Methods group consisted 101 primary NMIBC. Univariate followed by multivariate Cox proportional hazard regression analysis was performed obtain including smallest...
Although the role of melanoma risk factors is well documented, their correlation with patients' age less frequently analyzed.The analysis was performed among 189 patients in different groups, including <30 years, 31-60 and >60 to investigate factors, topography, coexistence morphological features 209 melanomas (dermoscopic histopathological).Among youngest group, no presence estimated found. The most common dermoscopic pattern spitzoid multicomponent asymmetric. group middle-aged diverse...
New scaffold materials composed of biodegradable components are great interest in regenerative medicine. These should be: stable, nontoxic, and biodegrade slowly steadily, allowing the stable release biologically active substances. We analyzed peptide-polysaccharide conjugates derived from peptides containing RGD motif (H-RGDS-OH (1), H-GRGDS-NH2 (2), cyclo(RGDfC) (3)) polysaccharides as scaffolds to select most appropriate biomaterials for application Based on results MTT Ki-67 assays, we...
<b>Introduction:</b> Tonsillectomy belongs to the most frequently performed surgical treatments; however, necessity of its performance is questioned. Therefore, there are many attempts unify and define indications for procedure. <br><b>Aim:</b> The main objective current dissertation was an analysis clinical symptoms occurring in patients qualified tonsillectomy, as well a comparison those with histopathological image removed tonsils repeatedly carried out,...
Palatine tonsil disease often coexists with dermatological diseases. Correct diagnosis of inflammation the palatine tissue and removal diseased tonsils results in remission disease.To determine similarities differences immunohistochemistry profile between tonsillitis hypertrophy, including location reactions specific histological sites.A prospective analysis 50 that had undergone tonsillectomy due to (30 cases) hypertrophy (20 was performed. The collected material underwent staining for:...
<h3>Introduction/Background</h3> PTEN (phosphatase and tensin homolog deleted on chromosome ten), BCL2 (B-cell lymphoma-2) PIK3CA (phosphatidylinositol 3 kinase) are connected with pathways potentially associated resistance to chemotherapy. <h3>Methodology</h3> The study group included 64 Caucasian women serous high-grade ovarian cancer (HGSOC) stage III-IV TNM/FIGO classification, treated 1st line platinum derivative based chemotherapy between 2004–2014. analysis of clinical data was...
This research paper presents a novel approach to identifying biomarkers that can be used prognosticate patients with triple-negative breast cancer (TNBC) eligible for neoadjuvant therapy. The study utilized survival and RNA sequencing data from cohort of TNBC identified 276 genes whose expression was related in such patients. gene were then classify into two major groups based on the presence or absence Wingless/Integrated-pathway (Wnt-pathway) mesenchymal (Mes) markers (Wnt/Mes). Patients...
Endoscopic sinus surgery is a standard procedure in the treatment of various pathologies such as chronic sinusitis or some types neoplasms. The transnasal approach to tumours paranasal sinuses favourable due functional and aesthetic reasons. We report rare case large primary ectopic meningioma 48-year-old woman referred Otolaryngology Clinic incidental finding pathologic mass visualised on orthopantomography picture. After diagnosis, patient was successfully treated with radical performed...
BACKGROUND: ALK receptor tyrosine kinase (ALK) aberrations have an established role in pathogenesis of many neoplasms, but their clinical significance high grade serous ovarian carcinoma (HGSOC) is unclear. OBJECTIVE: To analyse the frequency overexpression, molecular abnormalities ALK, and impact on progression-free survival (PFS) overall (OS) HGSOC. METHODS: Protein expression was examined by immunohistochemistry (IHC) using three different clones anti-ALK antibody. The presence...
Type 2 autoimmune polyendocrine syndrome (APS-2) is characterized by the presence of at least two three endocrinopathies: Addison's disease, thyroiditis, and diabetes type 1. The prevalence APS-2 estimated to be 1 : 1000 20.000 in general population. Diagnosis often delayed due its rarity wide spectrum clinical symptoms. Case Presentation. A 27-year-old presented with a 6-month history abdominal pain, vomiting, diarrhea, weakness, fatigue, 15 kg weight loss. patient was diagnosed Crohn's...