Magdalena Grażul

ORCID: 0000-0002-0325-5020
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About
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Research Areas
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Metal complexes synthesis and properties
  • Synthesis of Organic Compounds
  • Synthesis and biological activity
  • Bacterial biofilms and quorum sensing
  • Antimicrobial Resistance in Staphylococcus
  • Organometallic Compounds Synthesis and Characterization
  • Nigella sativa pharmacological applications
  • Molecular Sensors and Ion Detection
  • Click Chemistry and Applications
  • Essential Oils and Antimicrobial Activity
  • MicroRNA in disease regulation
  • Immune cells in cancer
  • Extracellular vesicles in disease
  • Retinoids in leukemia and cellular processes
  • Antimicrobial agents and applications
  • Synthesis and Characterization of Heterocyclic Compounds
  • Biochemical and Structural Characterization
  • Bacterial Identification and Susceptibility Testing
  • Ferrocene Chemistry and Applications
  • Cholinesterase and Neurodegenerative Diseases
  • Pharmacological Effects of Natural Compounds
  • Free Radicals and Antioxidants

Medical University of Lodz
2009-2023

University of Łódź
2019

Medical University of Warsaw
2019

Tumor-driven immune suppression is a major barrier to successful immunotherapy in ovarian carcinomas (OvCa). Among various mechanisms responsible for suppression, arginase-1 (ARG1)-carrying small extracellular vesicles (EVs) emerge as important contributors tumor growth and escape from the host system. Here, we report that EVs found ascites plasma of OvCa patients contain ARG1. suppress proliferation CD4+ CD8+ T-cells vitro vivo mouse models. In mice, ARG1-containing are transported draining...

10.1038/s41467-019-10979-3 article EN cc-by Nature Communications 2019-07-05

Coagulase-negative staphylococci (CoNS) are increasingly becoming a public health issue worldwide due to their growing resistance antibiotics and common involvement in complications related invasive surgical procedures, nosocomial urinary tract infections. Their behavior either as commensal or pathogen is result of strict regulation colonization virulence factors. Although functionality factors processes involved quite well understood S. aureus, little known about them CoNS species....

10.3390/ijerph20065155 article EN International Journal of Environmental Research and Public Health 2023-03-15

Ruthenium(ii) complexes are lately of great scientific interest due to their chemotherapeutic potential as anticancer and antimicrobial agents. Here we present the synthesis new pyrazole carbothioamide derivatives four arene-ruthenium complexes. The title compounds were characterized with application IR, NMR, mass spectrometry, elemental analysis X-ray diffraction. Additionally, for DFT calculations done. Their activity (MIC, MBC/MFC) was examined in vitro against Staphylococcus aureus,...

10.1039/c9ra08736b article EN cc-by-nc RSC Advances 2019-01-01

Coagulase-negative staphylococci belonging to S. haemolyticus, hominis subsp. hominis, simulans, and warneri are often described as etiological factors of infections. Staphylococci a phylogenetically coherent group; nevertheless, there differences among the species which may be important clinicians.We investigated selected virulence antibiotic resistance that were phenotypically demonstrated, presence expression genes encoding factors, type SCCmec cassette.The between tested revealed. A...

10.1186/s12879-020-4841-2 article EN cc-by BMC Infectious Diseases 2020-02-11

To meet the demand for alternatives to commonly used antibiotics, this paper evaluates antimicrobial potential of arene-ruthenium(II) complexes and their salts, which may be value in antibacterial treatment. Their activity (MIC, MBC/MFC) was examined vitro against

10.3390/molecules27020468 article EN cc-by Molecules 2022-01-12
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