A5003593981- Growth Hormone and Insulin-like Growth Factors
- Reproductive Physiology in Livestock
- Epigenetics and DNA Methylation
- Angiogenesis and VEGF in Cancer
- Cancer, Lipids, and Metabolism
- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- Birth, Development, and Health
- Ovarian cancer diagnosis and treatment
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Protein Kinase Regulation and GTPase Signaling
- Galectins and Cancer Biology
- TGF-β signaling in diseases
- Virus-based gene therapy research
- Systemic Sclerosis and Related Diseases
- Psoriasis: Treatment and Pathogenesis
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Caveolin-1 and cellular processes
- Multiple Sclerosis Research Studies
- Adrenal Hormones and Disorders
- Cancer-related Molecular Pathways
- Genomics, phytochemicals, and oxidative stress
- Cancer Immunotherapy and Biomarkers
Medical University of Warsaw
2015-2024
Postgraduate School of Molecular Medicine
2011
Kielanowski Institute of Animal Physiology and Nutrition
1975-1982
Tumor-driven immune suppression is a major barrier to successful immunotherapy in ovarian carcinomas (OvCa). Among various mechanisms responsible for suppression, arginase-1 (ARG1)-carrying small extracellular vesicles (EVs) emerge as important contributors tumor growth and escape from the host system. Here, we report that EVs found ascites plasma of OvCa patients contain ARG1. suppress proliferation CD4+ CD8+ T-cells vitro vivo mouse models. In mice, ARG1-containing are transported draining...
Lesions made in the anterior medial basal hypothalamus (MBH) pregnant or lactating ewes caused lack of development mammary gland and depressed milk yield, a decrease plasma prolactin concentration structural changes cells as manifested by expected degranulation (lack hormone release) atrophic diminished cell granulation (or granule synthesis). caudal MBH during pregnancy advanced gland, induced rapid increase extensive cells. These results indicate that at least two functional systems...
Serotonin or melatonin was infused into the 3rd cerebral ventricle (3rd V) medial basal hypothalamus (MBH) of both intact ewes and with lesions anterior hypothalamic area (AHA). Prolongation estrous cycle delay ovulation were obtained after infusions serotonin in lesioned ewes. Statistically, proved to be more effective this respect than The also blocked prevulatory peak LH. Furthermore, infusion behavior, while that did not affect function. effect indoleamine ewes, which inhibitory action...
AMA Kapka-Skrzypczak L, Wolinska E, Szparecki G, Czajka M, Skrzypczak M. The immunohistochemical analysis of membrane-bound CD55, CD59 and fluid-phase FH FH-like complement inhibitors in cancers ovary corpus uteri origin. Central European Journal Immunology. 2015;40(3):349-353. doi:10.5114/ceji.2015.54598. APA Kapka-Skrzypczak, L., Wolinska, E., Szparecki, G., Czajka, M., & Skrzypczak, (2015). Immunology, 40(3), 349-353. https://doi.org/10.5114/ceji.2015.54598 Chicago Lucyna, Ewa Grzegorz...
Summary. The relative proportions of prolactin cells, somatotrophs and gonadotrophs were determined in the adenohypophyses 28 Merino ewes on selected days during oestrous cycle. Plasma levels measured 16 animals at 3-hr intervals 24 hr before autopsy. From Days 1 to 5 cycle (Day 0=day ovulation), plasma 20-40 ng/ml cells filled with granules. increased 168 between 6 9, marked degranulation occurred. greatest was found 0, associated a surge concentration 610 ng/ml. rise intensive time...
True epithelial-lined cysts are rare forms of adrenal cystic lesions, the pathogenesis which is still not fully understood. In this report we present a case an cyst diagnosed incidentally on imaging in 31-year-old, previously healthy, obese woman. Due to non-specific hormonal disorders and enlargement lesion, right-sided laparoscopic adrenalectomy was performed. The lined predominantly by ciliated cuboidal-to-columnar, Müllerian-type epithelium, focally flat-to-cuboidal, mesothelium-like...
The aim of the present study was to evaluate role interleukin (IL)-6 and IL-8 on expression membrane-bound complement inhibitors membrane attack complex-inhibitory protein (CD59) decay-accelerating factor (CD55), in human ovarian carcinoma A2780 cell line, which is a non-producing IL-6 line that does exhibit responsiveness, due presence receptors. Extracellular levels system were evaluated by western blotting reverse transcription-quantitative polymerase chain reaction. Cellular localization...
Deleted in Liver Cancer (DLC) proteins belong to the family of RhoGAPs and are believed operate as negative regulators Rho small GTPases. So far, role first identified member from DLC family, DLC1, was established a tumor suppressor hepatocellular carcinoma. The function its close relative, DLC2 is unequivocal. In present study we attempted determine whether loss common feature carcinoma tissue. We examined two types carcinoma- typical fibrolamellar one. Our analysis revealed that protein...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Poletajew S, Wolińska E, Wasiutyński A, Dybowski B, Radziszewski P, Górnicka B. Immunohistochemical differentiation between muscularis mucosae and propria for improving the staging of bladder cancer in patients undergoing transurethral resection tumours. Polish Journal Pathology. 2017;68(3):218-224. doi:10.5114/pjp.2017.71529. APA Poletajew, S., Wolińska, E., Wasiutyński, A., Dybowski, B., Radziszewski, P., &...
Ovarian cancer remains one of the leading causes cancer-related deaths in women. There are several processes that described to have a causal relationship ovarian development, progression, and metastasis formation, occur both at genetic epigenetic level. One mechanisms involved its pathogenesis progression is estrogen signaling. Estrogen receptors ERα, ERβ GPER1, concert with various coregulators pioneer transcription factors, mediate effects estrogens primarily by transcriptional regulation...
The aim of the present study was to assess role interleukin (IL)‑6 and IL‑8 on expression fluid‑phase complement inhibitor, factor H (FH), FH‑like protein 1 (FHL‑1), in A2780 ovarian carcinoma cell line. This line does not normally produce IL‑6, however, is IL‑6 responsive due presence receptor for IL‑6. FH FHL‑1 lysates confirmed by western blotting. levels medium were determined enzyme‑linked immunosorbent assay. To evaluate gene expression, reverse transcription‑quantitative polymerase...
1. Heasman SJ, Ridley AJ. Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol. 2008; 9: 690–701. CrossRef Google Scholar
Abstract Purpose The aim of this study was to estimate endothelin‐ 1 (ET‐1) plasma level in multiple sclerosis patients. Methods Material 49 patients (13 males, 36 females, mean age: 40 year, range: 22‐ 62 years) suffering from according McDonalds rule. healthy controls consisted 3 males and 28 females (mean 38 19‐ 61 years). protocol approved by the Ethical Committee Postgraduate Medical Education Centre Warsaw, Poland. Endothelin‐ levels were determined ELISA Test (Immuno‐ Biological...