A5021111328- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Bladder and Urothelial Cancer Treatments
- Adrenal and Paraganglionic Tumors
- Urinary and Genital Oncology Studies
- Hormonal Regulation and Hypertension
- Urological Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Head and Neck Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Pituitary Gland Disorders and Treatments
- Viral-associated cancers and disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Nutrition, Genetics, and Disease
- Polyomavirus and related diseases
- Helicobacter pylori-related gastroenterology studies
- Hepatitis B Virus Studies
- Complement system in diseases
- Organ Donation and Transplantation
Medical University of Warsaw
2016-2025
University Medical Center
2024
Medical University of Silesia
2024
Institute of Cardiology
2024
Poznan University of Medical Sciences
2024
Universitair Ziekenhuis Brussel
2024
Cedars-Sinai Medical Center
2024
Institute of Molecular Pathology and Pathomorphology
2020
University of Warsaw
2009-2010
Centralny Szpital Kliniczny
2010
A single microRNA gene may give rise to several mature products that differ in length, called isomiRs. IsomiRs are known be tissue specific and functionally relevant. The sequence heterogeneity of the thyroid gland has yet determined. objective study was provide a comprehensive view transcriptome normal papillary carcinoma (PTC). We used next-generation deep sequencing analyze length expression profiles PTC tumors (n = 14), unaffected adjacent control, noncancerous 14). results were...
A wide use of imaging techniques results in more frequent diagnosis adrenal incidenataloma.To analyse the current state knowledge on incidentaloma adults order to prepare practical management recommendations.Following a discussion, Polish Society Endocrinology expert working group have analysed available data and summarised analysis form recommendations.Unenhanced computed tomography (CT) may be recommended as an initial assessment examination helpful differentiation between adenomas...
Lifetime risk of biliary tract cancer (BTC) in primary sclerosing cholangitis (PSC) may exceed 20%, and BTC is currently the leading cause death patients with PSC. To open new avenues for management, we aimed to delineate clinically relevant genomic pathological features a large panel PSC-associated (PSC-BTC).We analyzed formalin-fixed, paraffin-embedded tumor tissue from 186 PSC-BTC 11 centers eight countries all anatomical locations included. We performed DNA sequencing at 42 genetic loci...
To assess whether end-ischemic hypothermic oxygenated machine perfusion (HOPE) is superior to static cold storage (SCS) in preserving livers procured from donors after brain death (DBD).There increasing evidence of the benefits HOPE liver transplantation, but predominantly setting high-risk donors.In this randomized clinical trial, DBDs were randomly assigned either dual for at least 2 hours or SCS (1:3 allocation ratio). The Model Early Allograft Function (MEAF) was primary outcome measure....
To compare the efficacy of two quantitative methods for discrimination between benign and malignant focal liver lesions (FLLs): apparent diffusion coefficient (ADC) values T2 relaxation times. Seventy-three patients with 215 confirmed FLLs (115 benign, 100 malignant) underwent 1.5-T MRI respiratory-triggered single-shot SE DWI (b = 50, 400, 800) dual-echo T2TSE (TR 3,000 ms; TE1 84 TE2 228 ms). ADC times were calculated. Sensitivity, specificity accuracy both techniques in diagnosing...
Background: Hypothermic oxygenated machine perfusion has emerged as a strategy to alleviate ischemic-reperfusion injury in liver grafts. Nevertheless, there is limited data on the effectiveness of hypothermic evaluating organ quality. This study aimed introduce readily accessible real-time predictive biomarker measured perfusate for post-transplant graft function. Methods: The evaluated analytes over 90-day postoperative period 26 patients randomly assigned receive following dual prospective...
// Łukasz Koperski 1 , Marta Kotlarek 2 Michał Świerniak 2, 3 Monika Kolanowska Anna Kubiak Barbara Górnicka Krystian Jażdżewski and Wójcicka Department of Pathology, Medical University Warsaw, Poland Laboratory Human Cancer Genetics, Center New Technologies, CENT, Genomic Medicine, Correspondence to: Wójcicka, email: anna.wojcicka@uw.edu.pl Keywords: microRNA, adrenocortical carcinoma, cancer diagnostics, next-generation sequencing, NGS Abbreviations: AA, adenoma; ACC, carcinoma; NA, normal...
In aesthetic medicine, there has been an ongoing search for ideal dermal filler to offer zero complication rate. Polycaprolactone-based (PCL) available since 2009.The purpose of the paper was present a case granuloma as PCL injection, which not reported so far by other researchers. A 68-year-old female injected with PCL. One year later, nodules accompanied bluish skin discoloration developed within injection site. Ultrasound and histopathology studies were performed. The examinations...
A soluble complement inhibitor factor H (FH) and its splice variant H-like protein (FHL) have been recently discovered to play a major role in malignant cell escape from complement-mediated cytotoxicity lung-, ovarian- glia-derived neoplasms. The of FH colon cancer has not yet examined. Here, we studied immunocytochemically FH/FHL expression tumor samples derived 40 patients, with both primary adenocarcinoma metastatic foci the liver. immunoreactivity was present stroma tumors, virtually all...
Background Quantifying the fibrotic and calcific composition of aortic valve at CT angiography (CTA) can be useful for assessing disease severity outcomes patients with stenosis (AS); however, it has not yet been validated against quantitative histologic findings. Purpose To compare quantification tissue CTA versus examination. Materials Methods This prospective study included who underwent before either surgical replacement AS or orthotopic heart transplant (controls) two centers between...
was to analyze indications and results of the first one thousand liver transplantations at Chair Clinic General, Transplantation Liver Surgery, Medical University Warsaw.Data from 1000 (944 patients) performed Surgery between 1994 2011 were analyzed retrospectively. These included 943 55 retransplantations 2 re-retransplantations. Frequency particular for transplantation established. Perioperative mortality defined as death within 30 days after transplantation. Kaplan-Meier survival analysis...
Five germline genetic variants (rs116909374, rs965513, rs944289, rs966423, and rs2439302) have been associated in genome-wide association studies (GWAS) with increased risk of differentiated thyroid cancer (DTC), but their role mortality patients has not established. Also, no preoperative marker the clinical outcome had yet identified. The aim study was to investigate relationship between overall DTC.Retrospective 1,836 (1,643 women, 193 men) median age at diagnosis 49 years follow-up time...
Abstract Background and Aims Liver stiffness measurements (LSM), commonly performed by transient elastography (TE) or two‐dimensional shear wave (2D‐SWE), are used to quantify liver fibrosis. Active hepatitis, a hallmark of autoimmune hepatitis (AIH), could bias LSM. This might be overcome measurement spleen 2D‐SWE. Here, we compare 2D‐SWE TE biopsy (LB) in prospectively recruited patients with AIH. Methods We analysed relation 90 treated ≥ 6 months for were also compared LB 63 individuals...
Mesenteric fibromatosis with intestinal involvement mimicking a gastrointestinal stromal tumourIntroduction. or intra-abdominal desmoid tumour is rare proliferative disease affecting the mesentery. It locally aggressive that lacks metastatic potential, but local recurrence common. can be easily confused other primary tumours, especially of mesenchymal origin.Case report. We report case 44-year-old female who presented an abdominal mass radiologically and pathologically mimicked...
Objectives Staging of fibrosis in chronic liver disease is important for prognosis and treatment planning. Liver biopsy the gold standard assessment; however, new methods stiffness measurement exist which have not been evaluated patients with Wilson’s disease. To evaluate accuracy collagen proportionate area (CPA), transient elastography shear wave (SWE) assessment adult Methods In this retrospective study 60 disease, results percutaneous cutting assessed using Ishak score CPA were compared...
Objective. Some studies have found that people with type 2 diabetes mellitus are at increased risk of neoplasms, especially colorectal cancer (CRC). In other it is also suggested there a higher incidence in patients CRC. The aims this study were to assess whether the and impaired glucose tolerance (IGT) subjects CRC determine difference between diabetic healthy controls regarding metabolism (glycaemia, insulinaemia, serum levels C-peptide) as well insulin resistance sensitivity. Material...
Background and aims: Previous studies demonstrated a close correlation between transient elastography (TE) liver histology in chronic diseases. Data on the accuracy of TE primary sclerosing cholangitis (PSC) remains scarce. Here, we investigated association TE, serum marker injury explanted livers PSC patients.Methods: Thirty patients were prospectively recruited. (Fibroscan®) blood sampling performed during evaluation for transplantation (LT); second was day LT. Fibrosis according to...
The clinical picture of autoimmune hepatitis (AIH) varies markedly between patients, potentially due to genetic modifiers. aim this study was evaluate variants previously associated with fatty liver as potential modulators the AIH phenotype. cohort comprised 313 non-transplanted adults AIH. In all MARC1 (rs2642438), HSD17B13 (rs72613567), PNPLA3 (rs738409), TM6SF2 (rs58542926), and MBOAT7 (rs641738) were genotyped using TaqMan assays. Mitochondrial damage markers in serum analyzed relation...