A5003292433- Mitochondrial Function and Pathology
- ATP Synthase and ATPases Research
- Metabolism and Genetic Disorders
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Neurological diseases and metabolism
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Diet, Metabolism, and Disease
- Coenzyme Q10 studies and effects
- Cardiac Ischemia and Reperfusion
- Redox biology and oxidative stress
- Liver Diseases and Immunity
- Cell death mechanisms and regulation
- Retinoids in leukemia and cellular processes
- Trace Elements in Health
- Genetics, Aging, and Longevity in Model Organisms
- Diet and metabolism studies
- Adenosine and Purinergic Signaling
- Selenium in Biological Systems
- Metabolism, Diabetes, and Cancer
- Algal biology and biofuel production
- Photosynthetic Processes and Mechanisms
- Biochemical Acid Research Studies
Polish Academy of Sciences
2008-2025
Instytut Biologii Doświadczalnej im. Marcelego Nenckiego
2015-2024
University of Ferrara
2013-2018
General Department of Preventive Medicine
2013
University of Warsaw
2006-2008
The term "mitochondrial permeability transition" (MPT) refers to an abrupt increase in the of inner mitochondrial membrane low molecular weight solutes. Due osmotic forces, MPT is paralleled by a massive influx water into matrix, eventually leading structural collapse organelle. Thus, can initiate outer permeabilization (MOMP), promoting activation apoptotic caspase cascade as well caspase-independent cell death mechanisms. appears be mediated opening so-called "permeability transition pore...
The promyelocytic leukemia (PML) tumor suppressor is a pleiotropic modulator of apoptosis. However, the molecular basis for such diverse proapoptotic role currently unknown. We show that extranuclear Pml was specifically enriched at endoplasmic reticulum (ER) and mitochondria-associated membranes, signaling domains involved in ER-to-mitochondria calcium ion (Ca(2+)) transport induction found complexes large size with inositol 1,4,5-trisphosphate receptor (IP(3)R), protein kinase Akt,...
The pro-oncogenic transcription factor STAT3 is constitutively activated in a wide variety of tumours that often become addicted to its activity, but no unifying view core function determining this widespread STAT3-dependence has yet emerged. We show here active acts as master regulator cell metabolism, inducing aerobic glycolysis and down-regulating mitochondrial activity both primary fibroblasts STAT3-dependent tumour lines. As result, cells are protected from apoptosis senescence while...
Leber's hereditary optic neuropathy (LHON), a disease associated with mitochondrial DNA mutation, is characterized by blindness due to degeneration of retinal ganglion cells (RGCs) and their axons, which form the nerve.We show that sustained pathological autophagy compartment-specific mitophagy activity affects LHON patient-derived cybrids, as well induced pluripotent-stem-cell-derived neurons.This variably counterbalanced compensatory mitobiogenesis.The aberrant quality control disrupts...
The order of Cyanidiales comprises seven acido-thermophilic red microalgal species thriving in hot springs volcanic origin characterized by extremely low pH, moderately high temperatures and the presence concentrations sulphites heavy metals that are prohibitive for most other organisms. Little is known about physiological processes underlying long-term adaptation these extremophiles to such hostile environments. Here, we investigated adaptive responses a microalga Cyanidioschyzon merolae,...
Abstract Despite decades of research, the pathogenesis metabolic dysfunction‐associated steatotic liver disease (MASLD) is still not completely understood. Based on evidence from preclinical models, one factors proposed as a main driver development oxidative stress. This study aimed to search for resemblance between profiles stress and antioxidant defense in animal model MASLD group patients. C57BL/6J mice were fed with Western diet up 24 weeks served MASLD. The profile hepatic tissue was...
Preclinical models of ischemia/reperfusion injury (RI) demonstrate the deleterious effects permeability transition pore complex (PTPC) opening in first minutes upon revascularization occluded vessel. The ATP synthase c subunit (Csub) influences PTPC activity cells, thus impacting tissue injury. A conserved glycine-rich domain Csub is classified as critical because, when mutated, it modifies properties, protein interaction with mitochondrial calcium (Ca2+) uniporter complex, and conductance...
<title>Abstract</title> Leukemia cells residing in the bone marrow often exhibit resistance to tyrosine kinase inhibitors. Metabolic rearrangement of cancer has recently gained particular attention as a possible cause adaptation and insensitivity drug treatment. We demonstrated here that stromal directly transferred membrane vesicles together with proteins related tricarboxylic acid (TCA/Krebs) cycle leukemic cells. This transfer was dependent on direct cell-to-cell contact led increased...