A5039741682- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Bariatric Surgery and Outcomes
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Organ Donation and Transplantation
- Body Contouring and Surgery
- Cardiovascular Function and Risk Factors
- COVID-19 diagnosis using AI
- Adversarial Robustness in Machine Learning
- Bacillus and Francisella bacterial research
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Artificial Intelligence in Healthcare and Education
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Intestinal Malrotation and Obstruction Disorders
- Transplantation: Methods and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Mobile Agent-Based Network Management
- Liver physiology and pathology
- Advanced Glycation End Products research
Heidelberg University
2023-2025
German Cancer Research Center
2023-2025
Medical University of Warsaw
2016-2025
University of Oxford
2023
Wrocław University of Science and Technology
2008-2010
Institute of Computer Science
2010
Wojskowy Instytut Medyczny
2007
The nonalcoholic fatty liver disease is the most common abnormality. Up to date, biopsy reference standard for direct steatosis quantification in hepatic tissue samples. In this paper we propose a neural network-based approach assessment ultrasound.We used Inception-ResNet-v2 deep convolutional network pre-trained on ImageNet dataset extract high-level features B-mode ultrasound image sequences. level of each was graded by wedge biopsy. proposed compared with hepatorenal index technique and...
Roux-en-Y gastric bypass (RYGB) is considered the gold standard bariatric procedure with documented safety and effectiveness. Laparoscopic sleeve gastrectomy (LSG) a newer being done increasing frequency. Randomized comparisons of LSG other procedures are limited. We present results first prospective randomized trial comparing RYGB in Polish population.To assess efficacy versus treatment morbid obesity obesity-related comorbidities.Seventy-two morbidly obese patients were to (36 patients) or...
The aim of the study was to compare influence sleeve gastrectomy (SG) versus Roux-en-Y gastric bypass (RYGB) on liver function in bariatric patients with non-alcoholic fatty disease (NAFLD) a randomized clinical trial (NCT01806506).Rapid weight loss and malabsorption after surgery NAFLD or steatohepatitis (NASH) may impair function.Sixty-six morbidly obese SG RYGB were included secondary outcome analysis. Intraoperative biopsies categorized Activity Score (NAS) tests done before 1, 6 12...
Roux-en-Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy (LSG) are the two most frequently performed bariatric operations. These types of metabolic surgery alter anatomy function digestive tract producing significant weight loss in morbidly obese patients but may lead to malnutrition.Analysis incidence severity malnutrition after submitted RYGB or LSG during 12 months follow-up.Retrospective study 98 (n = 47) 51) assessed for nutritional deficiencies was conducted. The differences...
Abstract Despite decades of research, the pathogenesis metabolic dysfunction‐associated steatotic liver disease (MASLD) is still not completely understood. Based on evidence from preclinical models, one factors proposed as a main driver development oxidative stress. This study aimed to search for resemblance between profiles stress and antioxidant defense in animal model MASLD group patients. C57BL/6J mice were fed with Western diet up 24 weeks served MASLD. The profile hepatic tissue was...
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a hepatic manifestation of the metabolic syndrome. It one most common diseases worldwide and shows increasing prevalence rates in countries. MAFLD progressive with severe cases presenting as advanced fibrosis or cirrhosis an increased risk hepatocellular carcinoma. Gut microbiota play significant role pathogenesis progression by disrupting gut-liver axis. The mechanisms involved maintaining axis homeostasis are complex. One...
Abstract Background Liver steatosis is a common, usually asymptomatic hepatic disorder caused most often by insulin resistance and hepatotoxic factors. It currently regarded as sensitive imaging biomarker of the metabolic syndrome an independent risk factor future cardiovascular events. Diagnosis fatty liver in cardiologists office may be potential clinical value, revealing presence previously unknown influencing prognostic assessment, well treatment disease. The assessment during...
The aim of this study was to gain insight into the biochemical status cerebrospinal fluid in presence brain death life-supported patients. determined via vitro NMR spectroscopy (CSF) obtained by lumbar puncture from 22 patients with confirmed and compared that 34 control (without neurological diseases). Forty-one signals raw CSF samples 20 lipid extracts were analyzed using univariate multivariate statistical methods. ANOVA revealed significant differences all signals. No single marker found...
was to analyze indications and results of the first one thousand liver transplantations at Chair Clinic General, Transplantation Liver Surgery, Medical University Warsaw.Data from 1000 (944 patients) performed Surgery between 1994 2011 were analyzed retrospectively. These included 943 55 retransplantations 2 re-retransplantations. Frequency particular for transplantation established. Perioperative mortality defined as death within 30 days after transplantation. Kaplan-Meier survival analysis...
Abstract Purpose Bariatric surgery is no longer considered only as a weight loss but also way of treating obesity-related comorbidities such type 2 diabetes mellitus (T2DM). Short-term T2DM remissions in patients undergoing laparoscopic sleeve gastrectomy (LSG) have been shown, there are very few reports on the mid-term results. We aimed to assess remission rate obese after LSG throughout 5-year follow-up. Materials and Methodology performed retrospective multicenter cohort analysis 240 who...
Gallstone disease (GD) is common but remains asymptomatic in most cases. However, gallstones can lead to complications like choledocholithiasis or gallbladder cancer. In this study, we analyse the genetic risk factor for GD, p.D19H variant sterol transporter ABCG8, Polish patients with and
Convolutional neural networks (CNNs) have achieved remarkable success in medical image analysis tasks. In ultrasound (US) imaging, CNNs been applied to object classification, reconstruction and tissue characterization. However, can be vulnerable adversarial attacks, even small perturbations input data may significantly affect model performance result wrong output. this work, we devise a novel attack, specific imaging. US images are reconstructed based on radio-frequency signals. Since the...
Background The patients with nonalcoholic fatty liver disease demonstrate an increased cardiovascular risk. adverse influence of abnormalities on cardiac function are among many postulated mechanisms behind this association. aim the study was to evaluate morphology and in morbid obesity referred for bariatric surgery biopsy. Methods Results We evaluated echocardiography 171 consecutive without known (median age 42 [interquartile range, 37-48] years, median body mass index 43.7 41.0-47.5],...
Background: The need for safe and efficient dissemination of minimally invasive approach in liver surgery is among the current challenges hepatobiliary surgeons. After stage innovators pioneers, following countries should adopt a laparoscopic approach. aim this study was to assess national experience trend implementing resection (LLR) Poland. Materials Methods: A registry LLR performed Poland established June 2020. All cases before were included retrospectively, followed by prospectively...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Gierej P, B, Kalinowski et al. Expression of resistin in the liver patients with non-alcoholic fatty disease. Polish Journal Pathology. 2017;68(3):225-233. doi:10.5114/pjp.2017.67583. APA Gierej, P., B., Kalinowski, Wróblewski, T., Paluszkiewicz, R., & Kobryń, K. (2017). Pathology, 68(3), 225-233. https://doi.org/10.5114/pjp.2017.67583 Chicago Piotr, Beata Piotr Tadeusz Rafał Konrad and Bogna...
The severity of hepatic steatosis is modulated by genetic variants, such as patatin-like phospholipase domain containing 3 (PNPLA3) rs738409, transmembrane 6 superfamily member 2 (TM6SF2) rs58542926, and membrane-bound O-acyltransferase 7 (MBOAT7) rs641738. Recently, mitochondrial amidoxime reducing component 1 (MTARC1) rs2642438 hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) rs72613567 polymorphisms were shown to have protective effects on liver diseases. Here, we evaluate these...
Abstract Background Obesity increases and surgical weight reduction decreases the risk of atrial fibrillation (AF) heart failure (HF). We hypothesized that surgically induced loss may favorably affect left (LA) mechanical function measured by longitudinal strain, which has recently emerged as an independent imaging biomarker increased AF HF risk. Methods retrospectively evaluated echocardiograms performed before 12.2 ± 2.2 months after bariatric surgery in 65 patients with severe obesity...