A5057606031- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Bariatric Surgery and Outcomes
- Body Contouring and Surgery
- COVID-19 and healthcare impacts
- Diet and metabolism studies
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Gallbladder and Bile Duct Disorders
- Organ Transplantation Techniques and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Ethics in Clinical Research
- Gastrointestinal Tumor Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Breast Implant and Reconstruction
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Nutrition and Health in Aging
- Pharmaceutical industry and healthcare
- Social Media in Health Education
- Tracheal and airway disorders
- Galectins and Cancer Biology
- Sarcoma Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
Inserm
2016-2025
Université de Rennes
2016-2025
Centre Hospitalier Universitaire de Rennes
2016-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2025
Cliniques Universitaires Saint-Luc
2021-2025
Metropolitan University
2025
Nutrition, métabolismes et cancer
2017-2023
Institut de Virologie
2020-2022
Foie, Métabolisme, Cancer
2015-2022
Hôpital Pontchaillou
2016-2022
Few studies have evaluated the efficacy or cost of hypothermic oxygenated perfusion (HOPE) in conservation extended criteria donor (ECD) grafts from donation after brain death (DBD) donors during liver transplantation (LT). We performed a prospective, monocentric study (NCT03376074) designed to evaluate interest HOPE for ECD-DBD grafts. For comparison, control group was selected propensity score matching among patients who received transplants between 2010 and 2017. Between February November...
Background: Total esophageal reconstruction after failure of conventional techniques is a significant surgical challenge, particularly in fragile, multi-operated patients. Traditional options, including gastroplasties, colon transfers, and free jejunal flaps, carry high morbidity, rates, or complexity. Material Methods: We report an innovative four-step strategy for using presternal skin tube created with tissue expanders perforator flap techniques. Six patients prior definitive exclusion...
Intrahepatic cholangiocarcinoma (iCCA) is a deadly liver primary cancer associated with poor prognosis and limited therapeutic opportunities. Active transforming growth factor beta (TGFβ) signaling hallmark of the iCCA microenvironment. However, impact TGFβ on transcriptome tumor cells has been poorly investigated. Here, we have identified specific signature genes commonly deregulated in cell lines, namely HuCCT1 Huh28. Novel coding noncoding targets were identified, including TGFβ-induced...
<h3>Importance</h3> Clinical trial data sharing holds promise for maximizing the value of clinical research. The International Committee Medical Journal Editors (ICMJE) adopted a policy promoting in July 2018. <h3>Objective</h3> To evaluate association ICMJE with availability and reproducibility main conclusions among leading surgical journals. <h3>Design, Setting, Participants</h3> This cross-sectional study, conducted October 2021, examined randomized trials (RCTs) 10 journals before after...
Background Prognosis of distal cholangiocarcinoma (DCC) after pancreaticoduodenectomy (PD) remains poorly assessed. The aims this study were to describe the oncological results PD in DCC and compare its prognosis pancreatic ductal adenocarcinoma (PDAC). Methods All for periampullary carcinoma performed between January 2000 March 2013 extracted from a prospective database. Risk factors likely influence overall (OS) disease‐free (DFS) survivals assessed by multivariable analyses. PDAC...
Sex-determining region Y-box (SRY-box) containing gene 9 (SOX9) expression confers cancer stem cell features. However, SOX9 function in intrahepatic cholangiocarcinoma (iCCA) is unknown. This study investigated the effects and underlying mechanisms of iCCA. 59 iCCA patients was examined by immunohistochemistry. The association between clinical outcome evaluated. Gene signature biological functions were vitro. with high had shorter survival time than those low SOX9. In receiving chemotherapy,...
About 20% hepatocellular carcinomas (HCCs) display wild-type β-catenin, enhanced Wnt signaling, hepatocyte dedifferentiation and bad outcome, suggesting a specific impact of signals on HCC stem/progenitor cells. To study Wnt-specific molecular pathways, cell fates clinical we fine-tuned Wnt/β-catenin signaling in liver progenitor cells, using the prototypical ligand Wnt3a. Cell biology assays transcriptomic profiling were performed HepaRG hepatic progenitors exposed to Wnt3a after β-catenin...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer worldwide, as result of late diagnosis and limited therapeutic options. Tumour microenvironment (or stroma) plays key role in onset progression constitutes an intrinsic histological hallmark PDAC. Thus we hypothesised that relevant prognostic biomarkers targets can be identified the stroma. Methods Laser microdissection stroma from freshly frozen PDAC was combined to gene expression profiling. Protein candidate...
Although standardization of pancreaticoduodenectomy (PD) has improved postoperative outcomes, morbidity remains high. Fast-track surgery programs appear to improve morbidity, and avoiding nasogastric tube decompression (NGTD), already outdated in most major abdominal surgery, is strongly suggested after PD by fast-track but lacks high-level evidence, especially regarding safety.To assess a randomized clinical trial whether the absence systematic NGTD reduces complications.The IPOD study...
Objective: The aim of the study was to evaluate impact use a reinforced stapler (RS) during distal pancreatectomy (DP) on postoperative outcomes. Background: DP remains associated with significant morbidity owing pancreatic fistula (PF). To date, there is no consensus management stump. an RS potentially represents simple way decrease rate PF. Methods: REPLAY (NCT03030170) prospective, multicenter, randomized study. Patients who underwent were (1:1 ratio) in 2 groups for standard (SS) or...
How the side of an extended liver resection impacts postoperative prognosis advanced perihilar cholangiocarcinoma (PHC) is still controversial. We compared outcomes right (RTS) and left trisectionectomies (LTS) in Bismuth-Corlette (BC) type IV PHC resection. All patients undergoing RTS or LTS for BC a single tertiary center between January 2012 December 2019 were retrospectively. The endpoints perioperative outcomes, long-term overall (OS), disease-free survival (DFS). Among 67 hepatic...
The outcomes of bariatric surgery (BS) in patients with chronic inflammatory bowel disease (IBD) remain rarely described. We aimed to evaluate the 90-day morbidity and mortality rates, risk IBD complications 2 years after BS.Patients from French Programme de Médicalisation des Systèmes d'Information (PMSI) database who underwent a primary BS between 2016 2018 were included. identified previous diagnosis IBD. Postoperative (POD90) rates compared two groups. evolution was followed BS.Between...