A5071715362- Reconstructive Surgery and Microvascular Techniques
- Organ and Tissue Transplantation Research
- Breast Implant and Reconstruction
- Body Contouring and Surgery
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Wound Healing and Treatments
- Bone fractures and treatments
- Transplantation: Methods and Outcomes
- Reconstructive Facial Surgery Techniques
- Orthopedic Surgery and Rehabilitation
- Tissue Engineering and Regenerative Medicine
- Dermatologic Treatments and Research
- Facial Rejuvenation and Surgery Techniques
- Biomedical Ethics and Regulation
- Anorectal Disease Treatments and Outcomes
- Mesenchymal stem cell research
- Colorectal and Anal Carcinomas
- Hidradenitis Suppurativa and Treatments
- Engineering Applied Research
- Transcranial Magnetic Stimulation Studies
- Body Image and Dysmorphia Studies
- Lymphatic System and Diseases
- Skin Diseases and Diabetes
- Male Breast Health Studies
Harvard University
2022-2025
Centre Hospitalier Universitaire de Rennes
2021-2025
Massachusetts General Hospital
2022-2025
Université de Rennes
2021-2025
Inserm
2023-2025
Établissement Français du Sang
2024-2025
Shriners Hospitals for Children - Boston
2022-2024
Hôpital Pontchaillou
2024
Boston Children's Hospital
2024
Pendar Technologies (United States)
2024
Abstract Introduction Graft optimization is a necessity in order to develop uterus transplantation from brain‐dead donors, as complement living these grafts are rare and the last organs retrieved multiple organ donation. The aim of this study was assess feasibility interest hypothermic machine perfusion (HMP) using porcine model; secondary outcomes were evaluation graft's tolerance prolonged cold ischaemia time find new biomarkers viability. Material Methods Fifteen allotransplantations...
Vascularized composite allotransplantations are complex procedures with substantial functional impact on patients. Extended preservation of VCAs is major importance in advancing this field. It would result improved donor-recipient matching as well the potential for ex vivo manipulation gene and cell therapies. Moreover, it make logistically feasible immune tolerance induction protocols through mixed chimerism. Supercooling techniques have shown promising results multi-day liver preservation....
Ex vivo preservation of transplanted organs is undergoing spectacular advances. Machine perfusion now used in common practice for abdominal and thoracic organ transportation preservation, early results are favor substantially improved outcomes. It based on decreasing ischemia-reperfusion phenomena by providing physiological or sub-physiological conditions until transplantation. Alternatively, supercooling techniques involving static at negative temperatures while avoiding ice formation have...
Background. Warm ischemia time (WIT) and ischemia–reperfusion injury are limiting factors for vascularized composite allograft (VCA) transplantation. Subnormothermic machine perfusion (SNMP) has demonstrated the potential to extend WIT in organ This study evaluates effect of SNMP on VCA viability after prolonged WIT. Methods. Rat hindlimbs underwent 30, 45, 60, 120, 150, or 210 min, followed by 3-h SNMP. Monitoring parameters outflow determined maximum compatible with limb Thereafter, 2...
Background: Total esophageal reconstruction after failure of conventional techniques is a significant surgical challenge, particularly in fragile, multi-operated patients. Traditional options, including gastroplasties, colon transfers, and free jejunal flaps, carry high morbidity, rates, or complexity. Material Methods: We report an innovative four-step strategy for using presternal skin tube created with tissue expanders perforator flap techniques. Six patients prior definitive exclusion...
The current gold standard for preserving vascularized composite allografts (VCA) is 4°C static cold storage (SCS), albeit muscle vulnerability to ischemia can be described as early after 2 h of SCS. Alternatively, machine perfusion (MP) growing in the world organ preservation. Herein, we investigated outcomes oxygenated acellular subnormothermic (SNMP) 24-h VCA preservation before allotransplantation a swine model. Six partial hindlimbs were procured on adult pigs and preserved
Fasciocutaneous flaps (FCF) have become the gold standard for complex defect reconstruction in plastic and reconstructive surgery. This muscle-sparing technique allows transferring vascularized tissues to cover any large defect. FCF can be used as pedicled or free flaps; however, literature, failure rates are above 5%, leaving room improvement these techniques further knowledge expansion this area. Ischemic preconditioning (I.P.) has been widely studied, but mechanisms optimization of I.P....
Machine perfusion has developed rapidly since its first use in solid organ transplantation. Likewise, reconstructive surgery kept pace, and ex vivo appears as a new trend vascularized composite allotransplants preservation. In autologous reconstruction, fasciocutaneous flaps are now the gold standard due to their low morbidity (muscle sparing) favorable functional cosmetic results. However, failures still occasionally arise difficulties encountered with vessels during free flap transfer. The...
Vascularized composite allografts (VCA) face ischemic challenges due to their limited availability. Reperfusion following ischemia triggers oxidative stress and immune reactions, scavenger molecules could mitigate ischemia–reperfusion injuries and, therefore, rejection. We compared two scavengers in a myocutaneous flap VCA model. In total, 18 transplants were performed Major histocompatibility complex (MHC)-defined miniature swine. the MATCH group (n = 9), donors recipients had minor antigen...
Background: With the increasing demand for facial feminization surgery, there is a growing need reliable and reproducible techniques to enhance outcomes. Objective: This study aimed evaluate effectiveness of single-stage Naso-Orbito-Frontal (NOF) complex reshaping in surgery. Effectiveness was gauged by CT scan assessments an unvalidated patient satisfaction survey at 6 months post-operative. Methods: The included 155 transfeminine patients undergoing surgery upper third face. Outcomes were...
Abdominoperineal amputation (AAP) is a gold standard procedure treating advanced abdominal and pelvic cancers. The defect resulting from this extensive surgery must be reconstructed to avoid complications, such as infection, dehiscence, delayed healing, or even death. Several approaches can chosen depending on the patient. Muscle-based reconstructions are reliable solution but responsible for additional morbidity these fragile patients. We present discuss our experience in AAP reconstruction...