Giorgio De Santis

ORCID: 0000-0002-6717-5767
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About
Contact & Profiles
Research Areas
  • Reconstructive Surgery and Microvascular Techniques
  • Reconstructive Facial Surgery Techniques
  • Mesenchymal stem cell research
  • Facial Rejuvenation and Surgery Techniques
  • Dermatologic Treatments and Research
  • Dental Implant Techniques and Outcomes
  • Breast Implant and Reconstruction
  • Orthopedic Surgery and Rehabilitation
  • RNA Interference and Gene Delivery
  • Synthesis and Characterization of Heterocyclic Compounds
  • Wound Healing and Treatments
  • Financial Markets and Investment Strategies
  • Dermatological and COVID-19 studies
  • Cardiovascular Health and Disease Prevention
  • Body Contouring and Surgery
  • Facial Trauma and Fracture Management
  • Systemic Sclerosis and Related Diseases
  • Autoimmune and Inflammatory Disorders
  • Periodontal Regeneration and Treatments
  • Sarcoma Diagnosis and Treatment
  • Coronary Interventions and Diagnostics
  • Aortic aneurysm repair treatments
  • Cerebrovascular and Carotid Artery Diseases
  • Financial Risk and Volatility Modeling
  • Surgical site infection prevention

Azienda Ospedaliero-Universitaria di Modena
2015-2025

University of Modena and Reggio Emilia
2015-2025

Creative Commons
2016-2023

University Hospital of Lausanne
2022

Umicore (Belgium)
2020

Ghent University Hospital
2011-2018

CTO Hospital
2018

University of Insubria
2018

Ghent University
2009-2017

Società Italiana di Cardiologia
2016

ABSTRACT We test the conditional capital asset pricing model (CAPM) for world's eight largest equity markets using a parsimonious generalized autoregressive heteroskedasticity (GARCH) parameterization. Our methodology can be applied simultaneously to many assets and, at same time, accommodate general dynamics of moments. The evidence supports most restrictions model, but some variation in risk‐adjusted excess returns remains predictable during periods high interest rates. estimates indicate...

10.1111/j.1540-6261.1997.tb02745.x article EN The Journal of Finance 1997-12-01

10.1016/s0261-5606(97)00020-x article EN Journal of International Money and Finance 1997-08-01

We test the conditional CAPM for world's eight largest equity markets using a parsimonious GARCH parameterization. Our methodology can be applied simultaneously to many assets and, at same time, accommodate general dynamics of moments. The evidence supports most pricing restrictions model, but some variation in risk-adjusted excess returns remains predictable during periods high interest rates. estimates indicate that, although severe market declines are contagious, expected gains from...

10.2307/2329468 article EN The Journal of Finance 1997-12-01

Adipose-derived mesenchymal stromal/stem cells (AD-MSC) may offer efficient tools for cell-based gene therapy approaches. In this study, we evaluated whether AD-MSC could deliver proapoptotic molecules cancer treatment. Human AD-MSCs were isolated and transduced with a retroviral vector encoding full-length human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), that induces apoptosis in variety of cancers but not normal tissues. Although several studies have documented the...

10.1158/0008-5472.can-09-1865 article EN Cancer Research 2010-04-14

Seventeen benign peripheral nerve sheath tumors were studied using MR. In all cases T2 relaxation time, signal intensity on T1-weighted images (lesion/muscle ratio), detectability of origin, nerve-lesion relationship, and presence a capsule assessed. Sixteen showed marked hyperintensity T2-weighted with times values <95 ms. One schwannoma was almost isointense fat (T2 60 ms). All lesions muscle images. schwannomas the usually situated at periphery lesion only in one case it obliterated by...

10.1097/00004728-199107000-00013 article EN Journal of Computer Assisted Tomography 1991-07-01

We report a long-term follow-up (6.5 years) of phase I/II clinical trial envisaging the use autologous genetically modified cultured epidermal stem cells for gene therapy junctional epidermolysis bullosa, devastating genetic skin disease. The critical goals were to evaluate safety and persistence epidermis. A normal epidermal-dermal junction was restored regenerated transgenic epidermis found be fully functional virtually indistinguishable from control. sustained by discrete number...

10.1016/j.stemcr.2013.11.001 article EN cc-by-nc-nd Stem Cell Reports 2013-12-26

Thighplasty is a widely performed body contouring procedure, utilizing various surgical techniques for thigh lifting, including medial scar positioning, vertical and horizontal procedures, liposuction. Despite its popularity, thighplasty associated with high complication rates suboptimal postoperative outcomes.This article presents novel technique: the J combined helium plasma radiofrequency technology (HPRF) to address moderate skin soft-tissue laxity ptosis in inner thighs. Between 2020...

10.1097/prs.0000000000011962 article EN Plastic & Reconstructive Surgery 2025-01-14

Laminin 332-deficient junctional epidermolysis bullosa (JEB) is a severe genetic skin disease. JEB marked by epidermal stem cell depletion, the origin of which unknown. We show that dysregulation YAP and TAZ pathway underpins such depletion. 332-mediated activity sustains human cells, detected as holoclones. Ablation selectively depletes holoclones, while enforced blocks conversion cells into progenitors indefinitely extends keratinocyte lifespan. dramatically decreased in keratinocytes,...

10.1016/j.celrep.2019.04.055 article EN cc-by-nc-nd Cell Reports 2019-05-01

Postmastectomy pain syndrome (PMPS) represents a common complication following breast surgery defined as chronic neuropathic located in the front of chest, axilla and upper arm that for more than 3 months after surgery. Several medications prove to be ineffective while autologous fat grafting revealed an innovative solution treatment syndromes based on retrospective studies. For this reason, we performed prospective multicenter trial reduce memory bias further increase evidence results. From...

10.1111/tbj.13923 article EN The Breast Journal 2020-06-10

10.1016/s0148-6195(03)00049-3 article EN Journal of Economics and Business 2003-09-01

In this paper we study the dynamic behavior of stock returns and volatility in emerging financial markets. particular, focus our attention on following questions: o Does return markets change over time? If so, are changes predictable? How frequent big surprises markets? Is there any relationship between market risk expected returns? Has liberalization affected Our findings can be summarized as follows. First, is strong evidence predictable time-varying almost all countries. general, highly...

10.21034/dp.93 preprint EN cc-by-nc 1994-07-01

Autologous fat transfer (AFT) is a procedure for adipose tissue (AT) repair after trauma, burns, post-tumor resections and lipodystrophies still negatively impacted by the lack of graft persistence. The reasons behind this poor outcome are unclear seem to involve damages in either harvested/transplanted mature adipocytes or on their mesenchymal progenitors, namely stromal/stem cells (ASC), due post-transplant AT apoptosis involution. A rabbit subcutaneous regeneration model was here...

10.1007/s10495-013-0878-7 article EN cc-by APOPTOSIS 2013-07-04

To compare autologous fat transfer (AFT), injections of reabsorbable [polylactic acid (PLA)] and non-reabsorbable [polyacrylamide hydrogel (PAAG)] filler materials for the treatment HIV-related facial lipoatrophy.Eligible individuals with enough residual subcutaneous in abdomen or dorso-cervical region were offered AFT surgery. Other blindly assigned to two different surgical teams, who administered a set PLA PAAG every 4 weeks. The primary endpoint was measurement Bichat's pad region,...

10.1177/135965350501000606 article EN Antiviral Therapy 2005-08-01

The increasing use of injectable fillers has been the occurrence disfiguring anaerobic infection or granulomas. This study presents two types laser-assisted evacuation filler material and inflammatory necrotic tissue that were used to treat facial nodules after different gel fillers.Infectious lesions hydrogels drained using a lithium triborate laser at 532 nm, with subsequent removal infected pus (laser assisted evacuation). Granuloma gels containing microparticles treated an 808-nm diode...

10.1111/j.1524-4725.2009.01348.x article EN Dermatologic Surgery 2009-10-01
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