A5054331050- Cell death mechanisms and regulation
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Mesenchymal stem cell research
- Cancer-related Molecular Pathways
- Synthesis and Characterization of Heterocyclic Compounds
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Genetic factors in colorectal cancer
- HER2/EGFR in Cancer Research
- Genetics, Bioinformatics, and Biomedical Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protein Degradation and Inhibitors
- Pancreatic and Hepatic Oncology Research
- Monoclonal and Polyclonal Antibodies Research
- Neuroendocrine Tumor Research Advances
- Melanoma and MAPK Pathways
- Epigenetics and DNA Methylation
- Drug Transport and Resistance Mechanisms
- Retinoids in leukemia and cellular processes
Semmelweis University
2011-2023
University of Illinois Chicago
2020-2022
National Healthcare Service Center
2008-2015
Hungarian Academy of Sciences
1999-2013
Children's Hospital of Philadelphia
2010
University of Pennsylvania
2010
Meyer Children's Hospital
2010
HUN-REN Institute of Experimental Medicine
1997-2010
Helmholtz-Zentrum Berlin für Materialien und Energie
2010
Szent János Kórház
2006
Adipose-derived mesenchymal stromal/stem cells (AD-MSC) may offer efficient tools for cell-based gene therapy approaches. In this study, we evaluated whether AD-MSC could deliver proapoptotic molecules cancer treatment. Human AD-MSCs were isolated and transduced with a retroviral vector encoding full-length human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), that induces apoptosis in variety of cancers but not normal tissues. Although several studies have documented the...
For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that can also occur in regulated manner. Necroptosis, type of programmed is defined as death receptor-initiated under caspase-compromised conditions. The requires the kinase activity receptor-interacting protein 1 and 3 (RIPK1 RIPK3) mixed lineage domain-like (MLKL), substrate RIPK3. further downstream events remain elusive. We applied known inhibitors characterize contributing enzymes...
Recent studies have identified receptor tyrosine kinase-like orphan 1 (ROR1) on the surface of chronic lymphoid leukaemia (CLL) cells. In order to determine whether ROR1 expression is a suitable surrogate marker for diagnosis CLL we analysed mRNA level in different types non-Hodgkin lymphomas (NHL), and detected elevated levels compared control peripheral mononuclear cells several entities (CLL ≥ mantle cell lymphoma (MCL) > marginal zone (MZL) >> diffuse large B-cell follicular lymphoma)....
Cell death due to thymine (dThd) deficiency, associated with the cytotoxic action of 5-fluorouracil in colon cancer, is regulated thymidylate synthase-deficient (TS(-)) human carcinoma cells via Fas (CD95, APO-1) receptor. This was demonstrated by inhibiting loss clonogenicity TS(-) anti-FasL and enhanced survival clones selected for resistance Fas-mediated apoptosis, following dThd deprivation. During thymineless stress cells, ligand (FasL) expressed, its promoter (hFasLPr) activated....
Abstract 2‐methoxyestradiol (2ME 2 ) is an endogenous metabolite of estradiol with estrogen‐receptor‐independent antitumor and antiangiogenic activity. We examined the effects 2ME on cellular proliferation 8 human melanoma cell lines. show that inhibited by inducing apoptosis arrest in G /M phase, mechanism action involved microtubules, mitochondrial damage caspase activation. In male SCID mice, was effective reducing primary tumor weight number liver metastases after intrasplenic injection...
Precision oncology is currently based on pairing molecularly targeted agents (MTA) to predefined single driver genes or biomarkers. Each tumor harbors a combination of large number potential genetic alterations multiple in complex system that limits the this approach. We have developed an artificial intelligence (AI)-assisted computational method, digital drug-assignment (DDA) system, prioritize MTAs for each cancer patient individual molecular profile their tumor. analyzed clinical benefit...
Energy charge controls intermediary metabolism and cellular regulation. Here we show that inhibition of energy conservation at the level glucose uptake, glycolysis, citric acid cycle, oxidative phosphorylation induces cell death, leading to fragmentation DNA into an oligonucleosomal ladder morphological changes typical for apoptosis. Bc1‐2, prototype oncogenes suppress efficiently inhibits apoptosis induced by metabolic inhibitors. Bcl‐2 does not antagonize inhibitory potential mitochondrial...
The evaluation of the radial electron density profile a drug containing sterically stabilized liposomal system is described. Using synchrotron small-angle X-ray scattering, we were able to characterize hydrophilic shell polyethylene glycol chains. Gaussian model for describing along normal bilayer, got an asymmetric distribution PEGylated lipids in accordance with theoretical considerations. Moreover, used anomalous scattering study localization hydrophobic (a kinase inhibitor), which...
Rheumatoid Arthritis is a chronic disease leading to decreased quality of life with rather variable response rate Disease Modifying Anti Rheumatic Drugs. Methotrexate (MTX) the gold standard therapy in Arthritis. The Multidrug resistance Related Protein and Multi Drug Resistance protein 1, also called P-glycoprotein-170 transporters can alter intracellular concentration different drugs. an MRP1 substrate thus functional activity might have clinical impact on efficiency Methotrexate-therapy...
Gap juctions are transmembrane communication channels known to be involved in the control of cell proliferation by mediating exchange ions and small molecules between cells. junctions composed connexon hemichannels made up 6 connexin proteins, which abnormal expression functions have been linked tumor progression poorer prognosis. Here, we studied prognostic impact most prevalent isotype, 43 (Cx43) head neck squamous carcinomas (HNSCC). Tissue microarrays from samples 90 HNSCC patients were...
// Lilian Zsákai 1 , 3 * Anna Sipos 4 Judit Dobos Dániel Erős Csaba Szántai-Kis Péter Bánhegyi János Pató László Őrfi 2 Zsolt Matula Gábor Mikala György Kéri 6 # István Peták 5 and Vályi-Nagy Vichem Chemie Research Ltd., Budapest, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Hematology Stem Cell Transplantation, Central Hospital Southern Pest...