Bruno Sgromo
A5039218483- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Bariatric Surgery and Outcomes
- Liver Disease Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal disorders and treatments
- Dysphagia Assessment and Management
- Body Contouring and Surgery
- Galectins and Cancer Biology
- Obesity and Health Practices
- Helicobacter pylori-related gastroenterology studies
- Diabetes and associated disorders
- Delphi Technique in Research
- Lymphatic Disorders and Treatments
- Aldose Reductase and Taurine
- Tracheal and airway disorders
- Glycosylation and Glycoproteins Research
- Cardiovascular Function and Risk Factors
- Radiomics and Machine Learning in Medical Imaging
- Gastroesophageal reflux and treatments
- Enhanced Recovery After Surgery
Churchill Hospital
2010-2024
Oxford University Hospitals NHS Trust
2014-2024
University of Oxford
2011-2023
Erasmus University Rotterdam
2022
Royal College of Surgeons of England
2020
Cancer Research UK Oxford Centre
2014
John Radcliffe Hospital
2011
University of Dundee
2007
An important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of metastases depends on tumor characteristics such as location, histology, invasion depth, and neoadjuvant treatment. exact unknown. Neoadjuvant treatment surgical strategy the pattern nodal but consensus extent lymphadenectomy has not been reached. aim this study to determine resectable or gastro-esophageal junction whom a transthoracic esophagectomy 2- 3-field performed. This...
ObjectiveNon-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. Steroid hormones and bile acids are potent regulators carbohydrate lipid metabolism. 5β-reductase (AKR1D1) highly expressed in human where it inactivates steroid catalyzes a fundamental step acid synthesis.MethodsHuman biopsies were obtained from 34 obese patients AKR1D1 mRNA expression levels measured using qPCR. Genetic manipulation was performed HepG2 Huh7 cell lines. Metabolic...
Esophageal wall defects, including perforations and postoperative leaks, are associated with high morbidity mortality pose a significant management challenge. In light of the surgical or revision, in recent years, endoscopic vacuum therapy (EVT) has emerged as novel alternative treatment strategy. EVT involves transoral placement polyurethane sponge connected to an externalized nasogastric tube provide continuous negative pressure intention promoting defect healing, facilitating cavity...
Obesity, a major global health problem, is associated with increased cardiometabolic morbidity and mortality. Protein glycosylation frequent posttranslational modification, highly responsive to inflammation ageing. The prospect of biological age reduction, by changing patterns through metabolic intervention, opens many possibilities. We have investigated whether weight loss interventions affect inflammation- ageing-associated IgG changes, in longitudinal cohort bariatric surgery patients. To...
Significance Infection by the bacterium Helicobacter pylori is main risk factor for stomach cancer. Strains of H. that produce virulence CagA substantially increase cancer compared with strains without CagA. disrupts cell polarity—the specialized asymmetric organization within cells—but mechanism it uses and its influence on colonization are not fully understood. Using a three-dimensional culture cells (human gastric organoids) lines, we find tumor suppressor ASPP2 crucial in disruption...
Introduction Obesity affects cardiac geometry, causing both eccentric (due to increased output) and concentric insulin resistance) remodelling. Following bariatric surgery, reversal of processes should occur. Furthermore, epicardial adipose tissue loss following surgery may reduce pericardial restraint, allowing further chamber expansion. We investigated these changes in a serial imaging study depots geometry surgery. Methods 62 patients underwent magnetic resonance (CMR) before after...
There is considerable controversy regarding optimal management of patients with paraesophageal hiatus hernia (pHH). This survey aims at identifying recommended strategies for work-up, surgical therapy, and postoperative follow-up using Delphi methodology.We conducted a 2-round, 33-question, web-based on perioperative (preoperative procedure follow-up) non-revisional, elective pHH among European surgeons expertise in upper-GI. Responses were graded 5-point Likert scale analyzed descriptive...
Abstract Introduction Bariatric surgery is effective in reversing adverse cardiac remodelling obesity. However, it unclear whether the three commonly performed operations; Roux-en-Y Gastric Bypass (RYGB), Laparoscopic Sleeve Gastrectomy (LSG) and Adjustable Band (LAGB) are equal their ability to reverse remodelling. Methods Fifty-eight patients underwent CMR assess left ventricular mass (LVM), LV mass:volume ratio (LVMVR) eccentricity index (LVei) before after bariatric (26 RYGB, 22 LSG 10...
Enhanced recovery after surgery (ERAS) pathways aim to accelerate functional return and discharge from hospital. They have proven effective in many forms of surgery, most notably colorectal. However, experience esophagectomy has been limited. A recent study reported significant reductions pulmonary complications, mortality, length stay following the introduction an ERAS protocol alone, without any clinical changes. We instituted a similar change 16 months ago, introducing provide formal...
Abstract Delayed gastric conduit emptying (DGCE) after esophagectomy for cancer is associated with adverse outcomes and troubling symptoms. Widely accepted diagnostic criteria a symptom grading tool DGCE are missing. This hampers the interpretation comparison of studies. A modified Delphi process, using repeated web-based questionnaires, combined live interim group discussions was conducted by 33 experts within field, from Europe, North America, Asia. divided into early if present 14 days...
Background Although bariatric surgery is well established as an effective treatment for patients with obesity and type 2 diabetes mellitus (T2DM), there exists reluctance to increase its availability severe T2DM. The aims of this study were examine the impact on T2DM resolution in requiring insulin (T2DM-Ins) using data from a national database develop health economic model evaluate cost-effectiveness cohort when compared best medical (BMT). Methods findings Clinical National Bariatric...
Anastomotic leak (AL) is a common but severe complication after oesophagectomy. It unknown how to determine the severity of AL objectively at diagnosis. Determining may guide treatment decisions and improve future research. This study aimed identify leak-related prognostic factors for mortality, develop Severity oEsophageal Leak (SEAL) score.This international, retrospective cohort in 71 centres worldwide included patients with oesophagectomy between 2011 2019. The primary endpoint was...
To determine the impact of delayed surgical intervention following chemoradiotherapy (CRT) on survival from esophageal cancer.CRT is a core component multimodality treatment for locally advanced cancer. The timing surgery CRT may influence probability performing an oncological resection and associated operative morbidity.This was international, multicenter, cohort study, including patients 17 centers who received followed by between 2010 2020. In main analysis, were divided into 4 groups...
The ability to predict complications following esophagectomy/extended total gastrectomy would be of great clinical value. A recent study demonstrated significant correlations between anastomotic leak (AL) and numerical values C-reactive protein (CRP), white cell count (WCC) albumin measured on postoperative day (POD) 4. predictive model comprising all three (NUn score >10) was found highly sensitive discriminant in predicting AL complications. We attempted a retrospective validation our...
Abstract Background Risk assessment is relevant to predict postoperative outcomes in patients with gastro-oesophageal cancer. This cohort study aimed assess body composition changes during neoadjuvant chemotherapy and investigate their association complications. Methods Consecutive cancer undergoing surgery curative intent between 2016 2019 were identified from a specific database included the study. CT images before after used skeletal muscle index, sarcopenia, subcutaneous visceral fat...
Abstract Background Chyle leaks following oesophagectomy are a frustrating complication of surgery with considerable morbidity. The use near infra-red (NIR) fluorescence in is an emerging technology and the to identify thoracic duct has been demonstrated animal work early human case reports. This study evaluated mesenteric enteral administration indocyanine green (ICG) humans during oesophagectomy. Methods Patients undergoing were recruited study. Administration ICG via route or injection...
Abstract Background Anastomotic leak is a severe complication after oesophagectomy. has diverse clinical manifestations and the optimal treatment strategy unknown. The aim of this study was to assess efficacy strategies for different anastomotic Methods A retrospective cohort performed in 71 centres worldwide included patients with oesophagectomy (2011–2019). Different primary were compared three manifestations: interventional versus supportive-only local (that no intrathoracic collections;...
Oesophageal perforations and post-oesophagectomy anastomotic leaks are associated with high morbidity mortality. Endoscopic vacuum therapy (EVT) is a novel treatment strategy the potential to promote healing ameliorate sepsis. Only two cases of its use have been reported in UK management oesophageal wall defects, representing limited aetiological demographic spectrum.From May December 2019, 7 patients aged 27-85 years underwent EVT for disparate defects. Data regarding technical success...
The left thoracoabdominal approach to esophagectomy is not widely performed, despite offering excellent exposure tumors of the esophagogastric junction. Criticisms have focused on historically high rates mortality, complications, and positive resection margins. Our aim was determine whether could combine a radical oncological with acceptably low mortality morbidity. A retrospective cohort study all esophagectomies performed at single specialist center over an 11-year period. Primary outcomes...