A5074641986- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Nutrition and Health in Aging
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Virus-based gene therapy research
- Esophageal and GI Pathology
- Radiopharmaceutical Chemistry and Applications
- Enhanced Recovery After Surgery
- Cancer Treatment and Pharmacology
- Intellectual Property and Patents
- Chemokine receptors and signaling
- Lung Cancer Research Studies
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- Renal cell carcinoma treatment
- Metastasis and carcinoma case studies
Molecular Theranostics (United States)
2025
University of California, Los Angeles
2025
St Thomas' Hospital
2021-2023
Centre Hospitalier Universitaire de Bordeaux
2023
King's College London
2022-2023
Guy's and St Thomas' NHS Foundation Trust
2021-2023
St. Thomas Hospital
2021
Royal Adelaide Hospital
2016
University of Richmond
2010
Illinois Institute of Technology
2010
PURPOSE Breast cancer frequently overexpresses the product of HER2 proto-oncogene, a 185-kd growth factor receptor (p185HER2). The recombinant humanized monoclonal antibody (rhuMAb) has high affinity for p185HER2 and inhibits breast cells that overexpress HER2. We evaluated efficacy toxicity weekly intravenous administration rhuMAb in patients with HER2-overexpressing metastatic cancer. PATIENTS AND METHODS treated 46 carcinomas overexpressed Patients received loading dose 250 mg HER2, then...
PURPOSE There is limited evidence regarding the prognostic effects of pathologic lymph node (LN) regression after neoadjuvant chemotherapy for esophageal adenocarcinoma, and a definition LN response lacking. This study aimed to evaluate how influences survival surgery adenocarcinoma. METHODS Multicenter cohort patients with adenocarcinoma treated followed by surgical resection at five high-volume centers in United Kingdom. LNs retrieved esophagectomy were examined given score (LNRS)—LNRS 1,...
336 Background: Salvage radiation therapy (sRT) is standard of care for biochemically recurrent prostate cancer following radical prostatectomy (RP). In this setting, specific membrane antigen (PSMA) PET/CT has superior sensitivity and specificity identifying disease, especially at low (PSA) levels, can guide target volume delineation sRT. We set out to identify how PSMA guidance impacts long term clinical outcomes Methods: retrospectively screened five prospective studies conducted the...
We vaccinated metastatic melanoma patients with irradiated, autologous cells genetically engineered to secrete interleukin 2 (IL-2) investigate whether an anti-tumor immune response would be induced. Melanoma cell cultures were established from surgical specimens and IL-2 by infection recombinant retrovirus. Twelve subcutaneously one, two, or three times approximately 10 7 autologous, IL-2-secreting tumor cells. Treatment was well tolerated, local reactions at 11 of 24 injection sites minor...
Our purpose was to assess the activity of alpha-interferon (IFN-α), interleukin-2 (IL-2) and 5 fluorouracil (5FU) administered by protracted venous infusion (PVI) as opposed bolus injection. 55 patients with advanced renal cell cancer were treated follows: IL-2 IFN-α according schedule originally described Atzpodien, PVI 5FU 200 mg m–2 day–1 during weeks 5–9. 42 (76%) moderate or poor prognosis defined previous studies. The response rate intention treat 31% (17 55, three complete response,...
To determine the impact of delayed surgical intervention following chemoradiotherapy (CRT) on survival from esophageal cancer.CRT is a core component multimodality treatment for locally advanced cancer. The timing surgery CRT may influence probability performing an oncological resection and associated operative morbidity.This was international, multicenter, cohort study, including patients 17 centers who received followed by between 2010 2020. In main analysis, were divided into 4 groups...
Journal Article Prehabilitation exercise before oesophagectomy: long-term follow-up of patients declining/withdrawing from the program Get access William Knight, Knight Guy’s and St Thomas’ Oesophago-gastric Centre, London, UK Correspondence to: Department Gastrointestinal Medicine Surgery, NHS Foundation Trust, Westminster Bridge Road, London SE1 7EH, (e-mail: andrew.davies1@gstt.nhs.uk) https://orcid.org/0000-0002-8473-8402 Search for other works by this author on: Oxford Academic Google...
2-deoxy-2[18F]Fluoro-D-glucose (FDG) PET-CT has an emerging role in assessing response to neoadjuvant therapy oesophageal cancer. This study evaluated FDG predicting pathological tumour (pTR), nodal (pNR) and survival.Cohort of 75 patients with or oesophago-gastric junction (GOJ) adenocarcinoma treated chemotherapy then surgery at Guy's St Thomas' NHS Foundation Trust, London (2017-2020). Standardised uptake value (SUV) metrics on pre- post-treatment the primary (mTR) loco-regional lymph...