A5075523359- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Genomic variations and chromosomal abnormalities
- Molecular Biology Techniques and Applications
- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Dysphagia Assessment and Management
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Eosinophilic Disorders and Syndromes
- Tracheal and airway disorders
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Arrhythmias and Treatments
- Microscopic Colitis
- Lung Cancer Diagnosis and Treatment
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- Systemic Sclerosis and Related Diseases
- Mycobacterium research and diagnosis
- Potassium and Related Disorders
Guy's and St Thomas' NHS Foundation Trust
2017-2024
King's College Hospital
2023-2024
St Thomas' Hospital
2017-2024
King's College London
2019-2024
Faculty (United Kingdom)
2023
MRC Cancer Unit
2014-2022
University of Cambridge
2014-2022
Medical Research Council
2018-2022
St. Thomas Hospital
2021
Brain Physiology Lab
2021
Distinguishing between the inflammatory bowel disease (IBD), Crohn's (CD), and ulcerative colitis (UC) is important for both management prognostic reasons. Discrimination using noninvasive techniques could be an adjunct to conventional diagnostics. Differences have been shown intestinal microbiota of CD UC patients controls; gut bacteria influence specific urinary metabolites that are quantifiable proton high-resolution nuclear magnetic resonance (NMR) spectroscopy. This study tested...
The Lyon Consensus designates Los Angeles (LA) grade C/D esophagitis or acid exposure time (AET) >6% on impedance-pH monitoring (MII-pH) as conclusive for gastroesophageal reflux disease (GERD). We aimed to evaluate proportions with objective GERD among symptomatic patients LA A, B, and C endoscopy.Demographics, clinical data, endoscopy findings, proton-pump inhibitor response were collected from prospectively enrolled 2 referral centers. Off-therapy MII-pH parameters included AET, number of...
The role of inhaled and swallowed aeroallergens in treatment outcomes adult patients with eosinophilic esophagitis (EoE) is unclear. We hypothesized that the pollen season contributes to failure 6-food elimination diet (SFED) EoE.We compared EoE who underwent SFED during vs outside season. Consecutive skin prick test (SPT) for birch grass were included. Individual sensitization count data analyzed define whether each patient had been assessed or after SFED. All active (≥15...
Over a 16-year period, we conducted clinical study of malaria acquired worldwide in adults from malaria-nonendemic countries, to determine risk factors for severe Plasmodium falciparum malaria.All patients with confirmed who were managed by our unit 1991 2006 prospectively evaluated. Factors predicting disease severity according (1) strict World Health Organization (WHO) criteria, (2) composite measure unfavorable outcome, and (3) length hospital stay identified logistic linear regression...
<h3>Objective</h3> Barrett9s oesophagus shows appearances described as 'intestinal metaplasia', in structures called 'crypts' but do not typically display crypt architecture. Here, we investigate their relationship to gastric glands. <h3>Methods</h3> Cell proliferation and migration within glands was assessed by Ki67 iododeoxyuridine (IdU) labelling. Expression of mucin core proteins (MUC), trefoil family factor (TFF) peptides <i>LGR5</i> mRNA determined immunohistochemistry or situ...
Abstract Background The aim was to define the pathological response in lymph nodes following neoadjuvant chemotherapy for oesophageal adenocarcinoma and quantify any associated survival benefit. Methods Lymph retrieved at oesophagectomy were examined retrospectively by two pathologists evidence of a chemotherapy. Patients classified as node-negative (either negative with no previous tumour involvement or complete regression) positive (allocated node regression score based on proportion...
PURPOSE There is limited evidence regarding the prognostic effects of pathologic lymph node (LN) regression after neoadjuvant chemotherapy for esophageal adenocarcinoma, and a definition LN response lacking. This study aimed to evaluate how influences survival surgery adenocarcinoma. METHODS Multicenter cohort patients with adenocarcinoma treated followed by surgical resection at five high-volume centers in United Kingdom. LNs retrieved esophagectomy were examined given score (LNRS)—LNRS 1,...
Abstract Background Early cancer recurrence after oesophagectomy is a common problem, with an incidence of 20–30 per cent despite the widespread use neoadjuvant treatment. Quantification this risk difficult and existing models perform poorly. This study aimed to develop predictive model for early surgery oesophageal adenocarcinoma using large multinational cohort machine learning approaches. Methods Consecutive patients who underwent had treatment in one Dutch six UK oesophagogastric units...
Summary Background Low‐quality evidence suggests that pre‐operative exclusive enteral nutrition (E/EN) can improve postoperative outcomes in patients with Crohn's disease (CD). It is not standard practice most centres. Aims To test the hypothesis EN undergoing ileal/ileocolonic surgery for CD associated improved outcome. Methods We performed a single centre retrospective observational study comparing surgical receiving (≥600 kcal/day ≥2 weeks) those who received no nutritional optimisation....
Acid exposure time (AET) from ambulatory pH studies and reflux oesophagitis are independent measurements used by the Lyon classification to diagnose GORD. This study aimed validate AET reference ranges diagnostic thresholds analysis of 96-hour wireless healthy, asymptomatic controls (HCs) patients with without oesophagitis.HC consecutive referred for (off acid suppressants >7 days) underwent at two tertiary referral centres. Erosive was categorised Los Angeles (LA) classification. Linear...
Progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) is uncommon but the consequences are serious. Predictors of progression essential optimize resource utilization. This study assessed utility a promising panel biomarkers applicable routine paraffin embedded biopsies (FFPE) predict BE EAC in large population-based, nested case-control study.
Sebastian S Zeki, Ismail Miah, Pierfrancesco Visaggi, Anna Wolak, Minerva deSilva, Jason M Dunn, Andrew Davies, James Gossage, Abrie Botha, Guiping Sui, Jafar Jafari, and Terry Wong. J Neurogastroenterol Motil 2023;29:335-42. https://doi.org/10.5056/jnm22130
Radiofrequency ablation (RFA) is used to successfully eliminate Barrett's esophagus (BE)-related dysplasia or intramucosal carcinoma and aims cause reversion squamous epithelium. However, in 20% of cases RFA fails return the epithelium phenotype. Follow-up studies show a similar recurrence rate. We hypothesize that failed due clonally mutated epithelial populations harbored RFA-privileged sites can select for mutant clonal expansion.
To quantify the effects of COVID-19 on our inflammatory bowel disease (IBD) unit, including service provision, prescribing practices and use therapeutic drug monitoring (TDM).We performed a single centre retrospective observational cohort study. Data was extracted from IBD database, electronic patient records radiology/endoscopy reporting systems between 16/3/20-17/4/20 corresponding period in 2019.A similar number patients commenced biologic therapy before (n = 37) during pandemic 36)....
Previous analyses of the oesophageal circumferential resection margin (CRM) have focused on prognostic validity two different definitions a positive CRM, that College American Pathologists (tumour at margin) and Royal within 1 mm). This study aimed to analyse these explore risk recurrence survival with incremental tumour distances from CRM. cohort included patients who underwent for adenocarcinoma oesophagus between 2000 2014. Kaplan–Meier Cox regression were performed determine hazard ratio...
Lymphocytic esophagitis (LyE) and eosinophilic (EoE) are immune-mediated esophageal diseases. Clinical characteristics, endoscopic findings, treatment outcomes of LyE were compared with EoE. This was an international retrospective study on adults enrolled at 3 centers in Europe. We recorded clinical characteristics endoscopy findings baseline symptoms, histology, after patients Demographics, presentation, comorbidities, largely different 35 59 Proton pump inhibitor response generally lower...
2-deoxy-2[18F]Fluoro-D-glucose (FDG) PET-CT has an emerging role in assessing response to neoadjuvant therapy oesophageal cancer. This study evaluated FDG predicting pathological tumour (pTR), nodal (pNR) and survival.Cohort of 75 patients with or oesophago-gastric junction (GOJ) adenocarcinoma treated chemotherapy then surgery at Guy's St Thomas' NHS Foundation Trust, London (2017-2020). Standardised uptake value (SUV) metrics on pre- post-treatment the primary (mTR) loco-regional lymph...
<h3>ABSTRACT</h3> Barretts oesophagus represents the most significant risk factor for development of oesophageal adenocarcinoma (OAC), although majority patients will not develop cancer. However, early detection OAC and its precursors significantly improves outcome underlines importance endoscopic surveillance programmes. Clearly there is a discrepancy between small number people who need to undergo because they are at progression risk, large that do. Research therefore now concentrated on...
COVID-19 has severely affected UK endoscopy services with an estimate 86% loss of activity during the first wave. Subsequent delays in diagnostic and surveillance procedures highlight need for novel solutions to tackle resultant backlog. Transnasal (TNE) provides attractive option compared conventional upper gastrointestinal given its limited use space, no sedation reduced nursing resources.We describe piloting then establishing outpatient model TNE service pandemic era implications on...