A5000308084- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Helicobacter pylori-related gastroenterology studies
- Respiratory and Cough-Related Research
- Connective tissue disorders research
- Esophageal Cancer Research and Treatment
- Potassium and Related Disorders
- Cardiovascular Function and Risk Factors
- Gastrointestinal motility and disorders
- Eosinophilic Disorders and Syndromes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Wireless Body Area Networks
- Antenna Design and Analysis
- Obstructive Sleep Apnea Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Systemic Sclerosis and Related Diseases
- Ion Transport and Channel Regulation
- Intestinal and Peritoneal Adhesions
- Heart Rate Variability and Autonomic Control
- Hip disorders and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Issues in Pregnancy
Guy's and St Thomas' NHS Foundation Trust
2015-2024
Guy's Hospital
2016-2024
Faculty (United Kingdom)
2023
St Thomas' Hospital
2015-2023
King's College London
2023
King's College Hospital
2023
Brain Physiology Lab
2021
Queen Mary University of London
2010-2017
University of Edinburgh
2010
Wingate Institute
2010
Abstract Background Normal values of the esophageal motor function parameters for high‐resolution manometry ( HRM ‐ EPT ) adopted by Chicago classification were established using proprietary system Given Imaging. It is conceivable that normal a do not apply to data from others. Most studies based on supine swallows, whereas deglutition occurs mostly in upright position. We wished establish obtained with Sandhill's and compare results sitting positions. Methods Sixty‐nine healthy volunteers,...
Objective Gastro-oesophageal reflux is considered to be an important contributing factor in chronic unexplained cough. It remains unclear why some episodes the same patient causes cough while others do not. To understand more about mechanism by which induces cough, we aimed identify factors are triggering Design In this multicentre study, 49 patients with reflux-associated were analysed using 24-hour pH-impedance-pressure monitoring. The characteristics of that followed compared not...
High-resolution esophageal manometry (HRM) is a recent development used in the evaluation of function. Our aim was to assess inter-observer agreement for diagnosis motility disorders using this technology. Practitioners registered on HRM Working Group website were invited review and classify (i) 147 individual water swallows (ii) 40 diagnostic studies comprising 10 drop-down menu that followed Chicago Classification system. Data presented standardized format with pressure contours without...
ㅋSwallowing induces an inhibitory wave that is followed by a contractile along the esophageal body.Deglutitive inhibition in skeletal muscle of esophagus controlled brain stem whilst smooth muscle, intrinsic peripheral control mechanism critical.The latency between swallow and contractions determined pattern activation excitatory vagal pathways, regional gradients myenteric nerves, properties muscle.A precedes swallow-induced peristaltic contraction part human oesophagus involving both...
Pain is a ubiquitous yet highly variable experience. The psychophysiological and genetic factors responsible for this variability remain unresolved. We hypothesised the existence of distinct human pain clusters (PCs) composed profiles coupled with differences in perception brain processing pain. studied 120 healthy subjects whom baseline personality anxiety traits serotonin transporter-linked polymorphic region (5-HTTLPR) genotype were measured. Real-time autonomic nervous system parameters...
Acid exposure time (AET) from ambulatory pH studies and reflux oesophagitis are independent measurements used by the Lyon classification to diagnose GORD. This study aimed validate AET reference ranges diagnostic thresholds analysis of 96-hour wireless healthy, asymptomatic controls (HCs) patients with without oesophagitis.HC consecutive referred for (off acid suppressants >7 days) underwent at two tertiary referral centres. Erosive was categorised Los Angeles (LA) classification. Linear...
Summary Background Acid infusion in humans induces primary and secondary oesophageal hypersensitivity. The effects of pregabalin, a centrally‐acting modulator voltage‐sensitive calcium channels, on development acid‐induced hypersensitivity remain unknown. Aim To study the pregabalin healthy humans. Methods Placebo‐controlled, double‐blind, randomised, cross‐over 15 volunteers (six women, age 21–56 years). After manometry, baseline pain thresholds (PTs) to proximal electrical stimulation were...
Gastroesophageal reflux is considered to be a significant contributing factor chronic unexplained cough. Patients are often presumed have reflux-induced cough and exposed high-dose long-term empirical therapy with proton pump inhibitors (PPIs) despite the limited treatment efficacy in this population. We aimed assess diagnostic value of 24-hour ambulatory pH-impedance-pressure monitoring for diagnosis In multicenter study, we evaluated 192 patients using off PPIs. Manometry was used detect...
<h3>Introduction</h3> Dysphagia symptoms cannot always be explained by endoscopy or radiology investigations and clinicians may refer their patients for high-resolution manometry (HRM) when suspecting motility related dysphagia. There are a cohort of whom HRM also could not explain In this study, we perform the multichannel intraluminal impedance transit (MIIT) study to assess oesophageal time (OTT) in with unexplained <h3>Method</h3> Patients were selected between January 2018 December 2019...
<h3>Introduction</h3> A significant number of GORD patients (30%) continue to perceive symptoms despite PPI therapy. Impedance-pH studies have shown that proximal extent reflux and presence gas in the refluxate are only parameters associated with perception refractory GORD. Increased air swallowing (aerophagia) is often suspected based on clinical evaluation. More recently, increased between meals was demonstrated, using oesophageal impedance, a group abdominal (x-ray). Aerophagia during...