A5032419325- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Iron Metabolism and Disorders
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Hemoglobinopathies and Related Disorders
- Diabetes and associated disorders
- Diabetes Management and Research
- Bariatric Surgery and Outcomes
- Cellular transport and secretion
- Neuropeptides and Animal Physiology
- Erythrocyte Function and Pathophysiology
- Neuroendocrine Tumor Research Advances
- Genetics and Physical Performance
- Neonatal and fetal brain pathology
- Historical and Environmental Studies
- Photosynthetic Processes and Mechanisms
- Regulation of Appetite and Obesity
- Thermal Regulation in Medicine
- Microtubule and mitosis dynamics
- Lysosomal Storage Disorders Research
- RNA modifications and cancer
- Optimism, Hope, and Well-being
- CRISPR and Genetic Engineering
- Diverse academic and cultural studies
University of Oxford
2017-2024
Oxford Centre for Diabetes, Endocrinology and Metabolism
2017-2024
Churchill Hospital
2017-2023
University of Catania
2021
Heidelberg University
2014-2019
University Hospital Heidelberg
2019
European Molecular Biology Laboratory
2014-2019
European Institute of Oncology
2011
By restoring glucose-regulated insulin secretion, glucagon-like peptide-1–based (GLP-1–based) therapies are becoming increasingly important in diabetes care. Normally, the incretins GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) jointly maintain normal blood glucose levels by stimulation of secretion pancreatic β cells. However, reason why only GLP-1–based drugs effective improving after presentation has not been resolved. ATP-sensitive K+ (KATP) channels play a crucial role...
Abstract Aims/hypothesis Diabetes mellitus is associated with impaired insulin secretion, often aggravated by oversecretion of glucagon. Therapeutic interventions should ideally correct both defects. Glucagon-like peptide 1 (GLP-1) has this capability but exactly how it exerts its glucagonostatic effect remains obscure. Following release GLP-1 rapidly degraded from GLP-1(7–36) to GLP-1(9–36). We hypothesised that the metabolite GLP-1(9–36) (previously believed be biologically inactive) a...
Aims The gut hormone peptide tyrosine (PYY) is critical for maintaining islet integrity and restoring function following Roux‐en‐Y gastric bypass (RYGB). expression of PYY its receptors (NPYRs) in islets has been documented but not fully characterized. Modulation by the proteolytic enzyme dipeptidyl peptidase IV (DPP‐IV) investigated impact DPP‐IV inhibition on remains unexplored. Here we have addressed these gaps their effects glucose‐stimulated insulin secretion (GSIS). We also changes...
Summary The incretin hormone glucagon-like peptide 1(7-36) (GLP-1(7-36)) stimulates insulin and inhibits glucagon secretion. mechanisms by which GLP-1 suppresses release are unclear as glucagon-secreting α-cells express receptors (GLP-1Rs) at very low levels. Here, we examine the underlying mechanisms. We find that both GLP-1(7-36) its degradation product GLP-1(9-36) inhibit secretion physiological (pM) concentrations. Whereas effect of is sensitive to PKA inhibition, exerts a...
Mus musculus BL6 strains, specifically C57BL/6N and C57BL/6J, are frequently analyzed in an interchangeable manner as ‘wildtype’ controls without indication of the substrain. We hematological iron-related parameters C57BL/6J mice show differences hematocrit, mean corpuscular volume well non-heme iron content spleen, which was significantly higher compared to At molecular level, elevated splenic levels were associated with ferritin (FTL FTH) lower transferrin receptor 1 (TfR1) protein levels....
Mucopolysaccharidosis III (Sanfilippo syndromes) types A–D are rare lysosomal storage disorders characterized by heparan sulfate accumulation and neurodegeneration. Patients with MPS present developmental stagnation and/or regression, sleep disturbance, behavioral abnormalities usually in the first years of life. Epilepsy may occur a proportion patients during disease course. However, progression epilepsy EEG changes have not been systematically investigated. We report electroclinical...
The thesis is the renewed relationship between man and environment highlights need for a new conception of urban territory Government establishment sustainable cities. Cities are real engines regional development national and, in recent years, have become focus attention Community policies that consider completely different innovative than before.