A5102868100- Influenza Virus Research Studies
- Bariatric Surgery and Outcomes
- Vaccine Coverage and Hesitancy
- Organ Transplantation Techniques and Outcomes
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Liver Disease and Transplantation
- Hospital Admissions and Outcomes
- Gastroesophageal reflux and treatments
- Bacterial Infections and Vaccines
- Cardiac, Anesthesia and Surgical Outcomes
- Patient Safety and Medication Errors
- Innovations in Medical Education
- Surgical Simulation and Training
- Diversity and Career in Medicine
- Liver physiology and pathology
- Acute Myeloid Leukemia Research
- Appendicitis Diagnosis and Management
- Body Contouring and Surgery
- Chronic Myeloid Leukemia Treatments
- Hernia repair and management
- COVID-19 epidemiological studies
- Healthcare Operations and Scheduling Optimization
- Animal Disease Management and Epidemiology
- Peroxisome Proliferator-Activated Receptors
Brigham and Women's Hospital
2024-2025
Harvard University
2025
Sanofi (United States)
2024-2025
Cleveland Clinic
2019-2024
Sanofi (Canada)
2017-2024
York University
2017-2024
The Ohio State University
2024
Cleveland Clinic Lerner College of Medicine
2021
McMaster University
2021
Public Health Ontario
2018
CXC chemokines and their receptor, chemokine receptor-2 (CXCR2), are important components of the hepatic inflammatory response to ischemia/reperfusion (I/R). However, direct effects on hepatocytes during this have not been studied. Wild-type CXCR2−/− mice were subjected 90 minutes partial ischemia followed by up 96 hours reperfusion. had significantly less liver injury at all reperfusion times compared with wild-type mice. Early neutrophil recruitment (12 hours) was diminished in mice, but...
This case-control study examines the use of glucagon-like peptide-1 receptor agonist before metabolic and bariatric surgery its postoperative outcome.
The function of peroxisome proliferator-activated receptor-γ (PPARγ) in hepatic inflammation and injury is unclear. In this study, we sought to determine the role PPARγ ischemia/reperfusion mice. Male mice were subjected 90 minutes partial ischemia followed by up 8 hours reperfusion. was found be constitutively activated hepatocytes but not nonparenchymal cells. Upon induction ischemia, activation rapidly decreased remained suppressed throughout 8-hour reperfusion period. This reduced a...
Hematopoiesis is a complex process that relies on various cell types, signaling pathways, transcription factors and specific niche. The integration of these components critical importance to normal blood development, as deregulation may lead bone marrow failure or malignancy. Tle4, transcriptional corepressor, acts tumor suppressor gene in subset acute myeloid leukemia, yet little known about its function malignant hematopoiesis mammalian development. We report here Tle4 knockout mice are...
The COVID-19 pandemic created a paradigm shift in medical education with reliance upon alternative teaching methods to deliver meaningful surgery clerkship content. This study examines the efficacy of novel, case-based virtual curriculum determine its impact on student experience during quarantine.Sixteen third-year students enrolled General Surgery between April through June 2020 distancing at quaternary center (Cleveland Clinic, Cleveland, OH) participated this study. Course surveys,...
Abstract Hepatic ischemia/reperfusion (I/R) leads to liver injury and dysfunction through the initiation of a biphasic inflammatory response that is regulated by transcription factor nuclear κB (NF-κB). We have previously shown there an age-dependent difference in hepatic I/R mice correlates with divergent activation NF-κB such young greater activation, but less than old mice. In this study, we investigated mechanism which age alters during I/R. Young (4-5 weeks) (12-14 months) underwent...
Hepatic ischemia/reperfusion (I/R) results in a chain of events that culminate liver dysfunction and injury. I/R injury is characterized by early oxidant stress followed an intense acute inflammatory response involves the transcription factor nuclear (NF)‐κB. In addition to being primary regulator pro‐inflammatory gene expression, NF‐κB may play other roles hepatic I/R, such as mediating expression anti‐apoptotic genes, preventing accumulation damaging reactive oxygen species, facilitating...
Studies of patients who have undergone surgery while infected with COVID-19 shown increased risks for adverse outcomes in both pulmonary complications and mortality. It has become clear that the risk from perioperative infection must be weighed against delayed surgical treatment. also prior bariatric conveys protection mortality obesity is biggest factor adults under 45 years age. fully recovered underwent elective not widely available yet.This multi-institutional case series presented to...
Importance Beginning in 2005, the US implemented routine immunization of adolescents with a quadrivalent conjugate vaccine (MenACWY) for prevention invasive meningococcal disease (IMD). Objectives To assess whether MenACWY was associated reduced IMD burden among adolescent population and how downward trajectory that began mid-1990s might have evolved absence vaccination efforts. Design, Setting, Participants In this decision analytical study, bayesian hierarchical Poisson regression model...
Abstract Background Seasonal influenza poses a significant public health and economic burden, associated with the outcome of infection resulting complications. The true burden disease is difficult to capture due wide range presentation, from asymptomatic cases non-respiratory complications such as cardiovascular events, its seasonal variability. An understanding magnitude annual incidence important support prevention control policy development evaluate impact preventative measures...
At present there exists no commercially available product capable of capturing and broadcasting multimedia audiovisual data from teams performing high-risk work. We have developed such a recording analysis system for the purpose studying team behavior, which we currently use to observe record up 8 people working as co-located in hospital operating room. The has four collection computers, each one video stream 2 audio feeds. A separate software package is used synchronize view audio/video...
The applicability of laparoscopy to many complex intraabdominal colorectal procedures continues expand, and has been shown be feasible safe in experienced hands. Data are available on the elderly, rectal prolapse, diverticulitis, Hartman's takedown, small bowel obstruction, Crohn's disease, ulcerative colitis. Clinically relevant advantages have clearly demonstrated selected patient populations. Laparoscopic surgery for benign disease should considered patients suitable this approach an...