A5050548152- Astro and Planetary Science
- Stellar, planetary, and galactic studies
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Astrophysics and Star Formation Studies
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Data-Driven Disease Surveillance
- Travel-related health issues
- Astronomy and Astrophysical Research
- Planetary Science and Exploration
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- COVID-19 Pandemic Impacts
- Viral Infections and Vectors
- Innovation Diffusion and Forecasting
- Space Exploration and Technology
- COVID-19 Digital Contact Tracing
- Molecular Spectroscopy and Structure
- Space Science and Extraterrestrial Life
- Animal Disease Management and Epidemiology
- Viral gastroenteritis research and epidemiology
- Infection Control and Ventilation
- Viral Infections and Outbreaks Research
- Health Systems, Economic Evaluations, Quality of Life
University of Guelph
2014-2024
Sanofi (Canada)
2020-2024
Sanofi (France)
2018-2024
Sanofi (United States)
2018-2023
Sanofi (Mexico)
2018-2023
York University
2020-2022
Takeda (Canada)
2017
GlaxoSmithKline (Canada)
2013-2016
Northwestern University
2008-2010
University of Toronto
2005-2007
The ensemble of now more than 250 discovered planetary systems displays a wide range masses, orbits and, in multiple systems, dynamical interactions. These represent the end point complex sequence events, wherein an entire protostellar disk converts itself into small number bodies. Here, we present self-consistent numerical simulations this process, which produce results agreement with some key trends observed properties exoplanets. Analogs to our own solar system do not appear be common,...
Accurate forecasts can enable more effective public health responses during seasonal influenza epidemics. For the 2021-22 and 2022-23 seasons, 26 forecasting teams provided national jurisdiction-specific probabilistic predictions of weekly confirmed hospital admissions for one-to-four weeks ahead. Forecast skill is evaluated using Weighted Interval Score (WIS), relative WIS, coverage. Six out 23 models outperform baseline model across forecast locations in 12 18 2022-23. Averaging all...
One of the most challenging problems we face in our understanding planet formation is how Jupiter and Saturn could have formed before solar nebula dispersed. The popular model giant so-called 'core accretion' model. In this a large planetary embryo first, mainly by two-body accretion. This then followed period inflow nebular gas directly onto growing planet. core accretion has an Achilles heel, namely very first step. We undertaken comprehensive study process to date. numerically integrate...
We examined whether a high-dose inactivated influenza vaccine was more efficacious in preventing hospitalizations than standard-dose the Veterans Health Administration (VHA) senior population. This study estimated relative effectiveness (rVE) of high dose versus standard using retrospective cohort VHA patients 65 years age or older 2015–2016 season. To adjust for measured confounders, we matched each recipient with up to 4 recipients vaccinated at same location within 2-week period and...
We analyze the orbital evolution of terrestrial planetary embryos after oligarchic growth, including effect sweeping Jupiter secular resonance combined with tidal drag during depletion protoplanetary gas disk. Previous studies show that orbits isolated become unstable through long-term gravitational interaction. However, systems formed as a result giant impacts are generally very eccentric, unlike our solar system. Although mechanisms damp eccentricity have been proposed, such not only...
The outer giant planets, Uranus and Neptune, pose a challenge to theories of planet formation. They exist in region the solar system where long dynamical timescales low primordial density material would have conspired make formation such large bodies (∼15 17 times as massive Earth, respectively) very difficult. Previously, we proposed model that addressed this problem: Instead forming trans-Saturnian region, Neptune underwent most their growth among proto-Jupiter proto-Saturn, were scattered...
The tidal interaction between a disk and planet leads to the planet's migration. A long-standing question regarding this mechanism is how stop migration before planets plunge into their central stars. In paper, we propose new, simple significantly slow down migration, test possibility by using hybrid numerical integrator simulate disk-planet interaction. key component of scenario role low viscosity regions in protostellar disks known as dead zones, which affect planetary two ways. First all,...
We revisit the "dynamical shakeup" model of Solar System terrestrial planet formation, wherein whole process is driven by sweeping Jupiter's secular resonance as gas disk removed. Using a large number 0.5 Gyr-long N-body simulations, we investigate different outcomes produced such scenario. confirm that in contrast to existing models, combined with tidal damping can reproduce low eccentricities and inclinations, high radial mass concentration, planets. At same time, this also drives final...
We sought to gain insights into the determinants of seasonal influenza vaccine (SIV) uptake by conducting an age-stratified analysis (18–64 and 65+) factors associated with SIV among at-risk adults registered English practices. Records for between 2011 2016 were identified using Clinical Practice Research Datalink database. was assessed annually. The associations patient, practice, characteristics via cross-sectional longitudinal analyses, mixed-effects general estimating equation logistic...
The outbreak of Coronavirus disease, which originated in Wuhan, China 2019, has affected the lives billions people globally. Throughout 2020, reproduction number COVID-19 was widely used by decision-makers to explain their strategies control pandemic.
The observed orbits of extrasolar planets suggest that many giant migrate a considerable distance towards their parent star as result interactions with the protoplanetary disk, and some these become trapped in eccentricity-exciting mean motion resonances one another during this migration. Using three-dimensional numerical simulations, we find long timescale for damping planets' eccentricities by disk is close to or longer than disk-induced migration timescale, outer planet more half mass...
The discovery of over 400 extrasolar planets allows us to statistically test our understanding formation and dynamics planetary systems via numerical simulations. Traditional N-body simulations multiple-planet without gas disks have successfully reproduced the eccentricity (e) distribution observed systems, by assuming that are relatively closely packed when disk dissipates, so they become dynamically unstable within stellar lifetime. However, such studies cannot explain small semi-major...
Young planets interact with their parent gas disks through tidal torques. An imbalance between inner and outer torques causes bodies of mass $\ga 0.1$ Earth masses to lose angular momentum migrate inward rapidly relative the disk; this is known as ``Type I'' migration. However, protoplanets that grow giant mass, O($10^2) M_\oplus$, open a gap in disk are subsequently constrained more slowly, locked into disk's viscous evolution what called "Type II" In young planetary system, both Type I II...
We show that interaction with a gas disk may produce young planetary systems closely spaced orbits, stabilized by mean motion resonances between neighbors. On longer timescales, after the is gone, remnant planetesimal tends to pull these configurations apart, eventually inducing dynamical instability. find this can lead variety of outcomes; some cases resemble solar system, while others end up high-eccentricity orbits reminiscent observed exoplanets. A similar mechanism has been previously...
The adoption of quadrivalent influenza vaccine (QIV) to replace trivalent (TIV) in immunization programs is growing worldwide, thus helping address the problem B lineage mismatch. However, price per dose QIV higher than that TIV. In such circumstances, cost-effectiveness analyses provide important and relevant information inform national health recommendations implementation decisions. This analysis assessed potential impacts a country-wide switch from TIV QIV, Canada UK, third-party payer...
Background Consideration of cost determinants is crucial to inform delivery public vaccination programs. Objectives To estimate the average total laboratory‐confirmed influenza requiring hospitalization in Canadians prior to, during, and 30 days following discharge. analyze effects patient/disease characteristics, treatment, regional differences costs. Methods Study utilized previously recorded clinical resource use, outcomes patients admitted hospitals Serious Outcomes Surveillance ( SOS ),...
Trivalent inactivated influenza vaccines (IIV3s) protect against 2 A strains and one B lineage; quadrivalent versions (IIV4s) an additional lineage. The objective was to assess projected health economic outcomes associated with IIV4 versus IIV3 for preventing seasonal in the US. cost-effectiveness model developed interact a dynamic transmission model. tracked vaccination, cases, infection-spreading interactions, recovery over 10 y (2012-2022). estimated influenza-related complications,...