A5089131537- Influenza Virus Research Studies
- Respiratory viral infections research
- Geriatric Care and Nursing Homes
- Vaccine Coverage and Hesitancy
- Emergency and Acute Care Studies
- COVID-19 epidemiological studies
- Pneumonia and Respiratory Infections
- Health disparities and outcomes
- Frailty in Older Adults
- Intergenerational Family Dynamics and Caregiving
- Data-Driven Disease Surveillance
- Viral gastroenteritis research and epidemiology
- Congenital Diaphragmatic Hernia Studies
- Homelessness and Social Issues
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Neonatal Respiratory Health Research
- Bacterial Infections and Vaccines
- Primary Care and Health Outcomes
- Advanced Causal Inference Techniques
- Clinical Reasoning and Diagnostic Skills
- Infectious Encephalopathies and Encephalitis
- Healthcare Quality and Management
- Innovations in Medical Education
- Hemophilia Treatment and Research
University Medical Center Groningen
2019-2025
Sanofi (United States)
2018-2025
Brown University
2022-2025
Sanofi (France)
2021-2025
University of Groningen
2019-2024
Sanofi (Mexico)
2018-2024
Providence College
2023
Norwich University
2019
White River Junction VA Medical Center
2014-2018
Shine Micro (United States)
2017
We examined whether a high-dose inactivated influenza vaccine was more efficacious in preventing hospitalizations than standard-dose the Veterans Health Administration (VHA) senior population. This study estimated relative effectiveness (rVE) of high dose versus standard using retrospective cohort VHA patients 65 years age or older 2015–2016 season. To adjust for measured confounders, we matched each recipient with up to 4 recipients vaccinated at same location within 2-week period and...
Adults 65 years and older (seniors) experience more complications following influenza infection than younger adults. We estimated the relative vaccine effectiveness (rVE) of a trivalent high dose (HD-IIV3) versus an adjuvanted (aIIV3) in seniors for respiratory-related hospitalizations. conducted retrospective cohort study using claims data from Optum's Clinformatics® Data Mart to compare outcome rates between who received HD-IIV3 aIIV3 during 2016/17 2017/18, predominantly A/H3N2...
We sought to gain insights into the determinants of seasonal influenza vaccine (SIV) uptake by conducting an age-stratified analysis (18–64 and 65+) factors associated with SIV among at-risk adults registered English practices. Records for between 2011 2016 were identified using Clinical Practice Research Datalink database. was assessed annually. The associations patient, practice, characteristics via cross-sectional longitudinal analyses, mixed-effects general estimating equation logistic...
Older adults residing in long-term care facilities (LTCFs) are at a high risk of being infected with respiratory viruses, such as influenza and syncytial virus (RSV). Although these infections commonly have many cardiorespiratory sequelae, the national burden influenza- RSV-attributable events remains unknown for multimorbid vulnerable LTCF population. To estimate incidence hospitalizations that were attributable to RSV among residents quantify economic on US health system by estimating...
Seasonal influenza epidemics have a substantial public health and economic burden in the United States (US). On average, over 200,000 people are hospitalized an estimated 23,000 die from respiratory circulatory complications associated with seasonal virus infections each year. Annual direct medical costs indirect productivity across US been found to average respectively at $10.4 billion $16.3 billion. The objective of this study was estimate impact severe influenza-induced illness on...
In order to secure a safer and healthy work situation, the heavy physical loads imposed on 23 refuse collectors (aged 26-54) working in city of Haarlem, The Netherlands, were studied series three experiments between 1984 1987. aims respectively (1) study load for workers collecting dustbins or polythene bags; (2) introduce changes reduce avoid exceeding overload criteria by individual collectors; (3) investigate effects interventions improve efficiency collecting. maximal isometric lifting...
Observational studies of the relative effectiveness influenza vaccines are essential for public health decision making. Their estimates, however, subject to bias due unmeasured confounders. Instrumental variable (IV) methods can control observed and unobserved confounders.We used linked electronic medical record databases in Veterans Health Administration (VHA) as well Medicare administrative files examine vaccine (rVE) high-dose (HD) versus standard-dose (SD) preventing hospitalizations...
Respiratory syncytial virus (RSV) is a leading cause of infant hospitalization in the United States. Preterm infants and those with select comorbidities are at highest risk RSV-related complications. However, morbidity due to RSV infection not confined high-risk infants. We estimated burden medically attended (MA) RSV-associated lower respiratory tract (LRTI) among analyzed commercial (MarketScan Commercial [MSC], Optum Clinformatics [OC]), Medicaid [MSM]) insurance claims data for born...
Introduction Respiratory syncytial virus (RSV) is the leading cause of hospitalization among US infants. Characterizing service utilization during infant RSV hospitalizations may provide important information for prioritizing resources and interventions. Objective The objective this study was to describe procedures services received by infants hospitalized their first episode in season, addition what proportion died hospitalization. Methods In retrospective observational study, we analyzed...
Abstract Background A growing number of real-world studies are using health administrative data to estimate relative vaccine effectiveness (rVE) due ease access and lower cost. To inform evidence-based decision making, meta-analyses rVE estimates often employed summarize the volume studies; however, low statistical power, unmeasured confounding, publication bias threaten validity meta-analyzed estimates. Our objective was demonstrate impact these biases on simulation. Methods We simulated a...
Abstract Background The emergence of SARS-CoV-2 has profoundly impacted global healthcare systems, raising concerns about its interaction with seasonal influenza and the appropriateness concomitant vaccination campaigns. This study aims to compare burden timing COVID-19 influenza-associated hospitalizations during post-pandemic period.Figure 1:Evolution Influenza Covid-19 activity by season over 2022-2023 2023-2024 Methods We retrospectively analyzed laboratory-confirmed hospitalization data...
Abstract Background Patient-reported outcomes (PRO) and self-swab studies may offer to improve monitoring of infectious diseases. The DANFLU-2 HomeSwab PRO study aimed assess the practicality self-administered swabs digital tracking monitor influenza-like illness (ILI). Methods As part a sub-study trial, participants were instructed self-report ILI quality life (QoL) using Respiratory Intensity Impact Questionnaire (RiiQ) for 14 days following symptom onset. If symptomatic, home-based was...
Background Respiratory syncytial virus (RSV) is the leading cause of infant hospitalization in United States. Understanding healthcare utilization associated with medically attended (MA) RSV lower respiratory tract infection (LRTI) might inform research priorities aimed at reducing RSV-associated pediatric morbidity. We described during acute MA LRTI episodes within a geographically diverse cohort infants Methods created retrospective cohorts born States from July 1, 2016 through February...
Older adults who reside in long-term care facilities (LTCFs) are at particularly high risk for infection, morbidity and mortality from pneumonia influenza (P&I) compared to individuals of younger age those living outside institutional settings. The factors P&I hospitalizations that specific LTCFs remain poorly understood. Our objective was evaluate the incidence hospitalization associated person- facility-level among post-acute (short-stay) (long-stay) residents residing 2013 2015. In this...
Respiratory syncytial virus (RSV) is a major cause of morbidity and mortality among US infants. A child's calendar birth month determines their age at first exposure(s) to RSV. We estimated month-specific risk medically attended (MA) RSV lower respiratory tract infection (LRTI) infants during season year life (FYOL). analyzed born in the USA between July 2016 February 2020 using three insurance claims databases (two commercial, one Medicaid). classified infants' MA LRTI episode by highest...
Learning about quality improvement (QI) in resident physician training is often relegated to elective or noncore clinical activities. The authors integrated teaching, learning, and doing QI into the routine work of inpatient internal medicine teams at a Veterans Affairs (VA) hospital. This study describes design factors that facilitated inhibited integration curriculum-including real work-into teams.A realist evaluation framework used three data sources: field notes from faculty;...
Integrating teaching and hands-on experience in quality improvement (QI) may increase the learning impact of resident QI work.We sought to determine clinical educational an integrated curriculum.This clustered, randomized trial with early late intervention groups used mixed methods evaluation. For almost 2 years, internal medicine residents from Dartmouth-Hitchcock Medical Center on inpatient teams at White River Junction VA participated curriculum. project effectiveness was assessed using...
Pneumonia and influenza (P&I) increase morbidity mortality among older adults, especially those residing in long-term care facilities (LTCFs). Facility-level characteristics may affect the risk of P&I beyond resident-level factors. However, relationship between facility is poorly understood. To address this, we identified potentially modifiable facility-level that influence incidence across LTCFs. We conducted a retrospective cohort study using 2013-2015 Medicare claims linked to Minimum...
Influenza may contribute to coronary/cerebrovascular events and exacerbate underlying conditions. We used self-controlled case series (SCCS) design analyze data from US Veterans ≥18 years with or exacerbation event +/-1 year of lab-confirmed influenza (LCI) during 2010-2018. estimated the incidence ratio (IR) (95% CI) for risk interval (Days 1-7 post-LCI) versus control (all other times LCI) fixed-effects conditional Poisson regression. included biomarker mediation analysis. identified 3439...
Background Pneumonia and sepsis are among the most common causes of hospitalization in United States often result discharges to a skilled nursing facility (SNF) for rehabilitation. We described timing 30-day unplanned hospital readmission following an index pneumonia or sepsis. Methods findings This national retrospective cohort study included adults ≥65 years who were hospitalized discharged SNF between July 1, 2012 4, 2015. quantified ten diagnoses estimated daily risk first...
To compare the economic impact of high-dose trivalent (HD) versus standard-dose (SD) influenza vaccination on direct medical costs for cardio-respiratory hospitalizations in adults aged 65 years or older enrolled United States (US) Veteran's Health Administration (VHA).Leveraging a relative vaccine effectiveness study HD SD over five respiratory seasons (2010/11 through 2014/15), we collected cost data healthcare provided to same population both at VHA and Medicare services. Our assessment...
Abstract There is large county-level geographic variation in pneumonia and influenza hospitalizations among short-stay long-stay long-term care facility residents the United States. Long-term facilities counties Southern Midwestern regions had highest rates of from 2013 to 2015. Future research should identify reasons for these differences.