Clotilde El Guerche‐Séblain

ORCID: 0000-0003-0196-4357
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About
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Research Areas
  • Influenza Virus Research Studies
  • Respiratory viral infections research
  • COVID-19 epidemiological studies
  • Data-Driven Disease Surveillance
  • Vaccine Coverage and Hesitancy
  • Pneumonia and Respiratory Infections
  • SARS-CoV-2 and COVID-19 Research
  • Viral Infections and Outbreaks Research
  • Immune responses and vaccinations
  • Animal Disease Management and Epidemiology
  • Smoking Behavior and Cessation
  • Infectious Encephalopathies and Encephalitis
  • COVID-19 Pandemic Impacts
  • COVID-19 diagnosis using AI
  • COVID-19 and Mental Health
  • COVID-19 Clinical Research Studies
  • COVID-19 Digital Contact Tracing
  • Zoonotic diseases and public health
  • Monoclonal and Polyclonal Antibodies Research
  • Diabetes and associated disorders
  • Viral Infections and Vectors

Sanofi (France)
2016-2025

University of the Witwatersrand
2024

Vrije Universiteit Amsterdam
2023

Geneeskundige en Gezondheidsdienst
2023

AZ Sint-Lucas
2023

Portál (Czechia)
2023

Portal (Norway)
2023

Université Claude Bernard Lyon 1
2020-2022

Hôpital Edouard Herriot
2022

Sanofi (Mexico)
2020-2021

BackgroundData on COVID-19-induced disruption to routine vaccinations in the South-East Asia and Western Pacific regions (SEAR/WPR) have been sparse. This study aimed quantify impact of COVID-19 by country, antigen, sector (public or private), up 1 June 2020, identify reasons for possible solutions.MethodsSanofi Pasteur teams from 19 countries SEAR/WPR completed a structured questionnaire reporting disruptions 13–19 routinely delivered antigens per based sales data, government reports,...

10.1016/j.lanwpc.2021.100140 article EN cc-by The Lancet Regional Health - Western Pacific 2021-04-21

We describe the epidemiological characteristics, pattern of circulation, and geographical distribution influenza B viruses its lineages using data from Global Influenza Study. included over 1.8 million cases occurred in thirty-one countries during 2000–2018. calculated proportion caused by lineages; determined timing A epidemics; compared age B/Victoria B/Yamagata cases; evaluated frequency lineage-level mismatch for trivalent vaccine. The median virus was 23.4%, with a tendency (borderline...

10.1371/journal.pone.0222381 article EN public-domain PLoS ONE 2019-09-12

COVID-19 was an unprecedented challenge worldwide; however, disease epidemiology has evolved, and no longer constitutes a public health emergency of international concern. Nonetheless, remains global threat uncertainties remain, including definition the end pandemic transition to endemicity, understanding true rates SARS-CoV-2 infection/transmission.

10.1080/14760584.2024.2346589 article EN cc-by-nc Expert Review of Vaccines 2024-04-24

Background The Global Influenza Hospital Surveillance Network was established in 2012 to obtain valid epidemiologic data on hospital admissions with influenza-like illness. Here we describe the epidemiology of influenza within Northern Hemisphere sites during 2013/2014 season, identify risk factors for severe outcomes and complications, assess impact different viruses clinically relevant at-risk populations. Methods Eligible consecutive were screened inclusion at 19 hospitals Russia, Turkey,...

10.1371/journal.pone.0154970 article EN cc-by PLoS ONE 2016-05-19

Description of the epidemiology influenza is needed to inform vaccination policy. Here we examined virus circulation in countries Asia-Pacific region and compared timing seasonal epidemics with vaccination. Data were obtained from World Health Organization (WHO) FluNet database for 2010-2017 WHO region. covering ≥5 consecutive seasons ≥ 100 positive cases per year included. Median proportions each type calculated by country season. The amplitude epidemic peaks determined Fourier...

10.1186/s12889-019-6647-y article EN cc-by BMC Public Health 2019-03-21

Abstract Background National Influenza Centers (NICs) have played a crucial role in the surveillance of SARS‐CoV‐2. The FluCov project, covering 22 countries, was initiated to monitor impact SARS‐CoV‐2 pandemic on influenza activity. Methods This project consisted an epidemiological bulletin and NIC survey. survey, designed assess system, shared with 36 NICs located across countries. were invited reply between November 2021 March 2022. Results We received 18 responses from 14 Most (76%)...

10.1111/irv.13140 article EN cc-by Influenza and Other Respiratory Viruses 2023-05-01

Abstract Background Influenza A(H3N2) viruses exhibit significant genetic diversity and mutations may escape acquired host immunity, potentially triggering infections among vaccinees. This study aims to explore associations between changes in vaccinal status of their adult hosts vaccinated with quadrivalent attenuated standard dose (SD-IIV4) vaccine, recombinant (RIV4) or not vaccinated, alongside exploration other demographics. Overview virus populations characteristics. On the left part is...

10.1093/ofid/ofae631.913 article EN cc-by Open Forum Infectious Diseases 2025-01-29

Abstract Background The emergence of SARS-CoV-2 has profoundly impacted global healthcare systems, raising concerns about its interaction with seasonal influenza and the appropriateness concomitant vaccination campaigns. This study aims to compare burden timing COVID-19 influenza-associated hospitalizations during post-pandemic period.Figure 1:Evolution Influenza Covid-19 activity by season over 2022-2023 2023-2024 Methods We retrospectively analyzed laboratory-confirmed hospitalization data...

10.1093/ofid/ofae631.139 article EN cc-by Open Forum Infectious Diseases 2025-01-29

Background: Data on COVID-19-induced disruption to routine vaccinations in the South-East Asia and Western Pacific regions (SEAR/WPR) have been sparse. This study aimed quantify impact of COVID-19 by country, antigen, sector (public or private), up 1 June 2020, identify reasons for possible solutions. Methods: Sanofi Pasteur teams from 19 countries SEAR/WPR completed a structured questionnaire reporting disruptions 13–19 routinely delivered antigens per based sales data, government reports,...

10.2139/ssrn.3754264 article EN SSRN Electronic Journal 2020-01-01

Despite World Health Organization recommendations, in many countries young children are not targeted for influenza vaccination. To help inform vaccination policy, we examined the occurrence and burden of healthy aged 6 to 35 months using data from a recent phase III placebo-controlled vaccine trial conducted Northern Southern Hemispheres. This was an analysis participants included placebo arm clinical (EudraCT no. 2013–001231-51). Included had never been vaccinated were observed one season....

10.1186/s12879-019-3920-8 article EN cc-by BMC Infectious Diseases 2019-04-04

Abstract Background The Western Pacific Region (WPR) is exposed each year to seasonal influenza and often the source of new virus variants novel pathogen emergence. National surveillance systems play a critical role in detecting emerging viruses, monitoring epidemics, improving public disease awareness promoting pandemic preparedness, but vary widely across WPR countries. aim this study improve existing by systematically comparing selected systems. Methods Three national with different...

10.1186/s12889-021-11765-x article EN cc-by BMC Public Health 2021-09-26

Background The risk of hospitalization or death after influenza infection is higher at the extremes age and in individuals with comorbidities. We estimated number hospitalizations characterized cumulative comorbidities on severe outcomes Mexico Brazil. Methods used national hospital discharge data from Brazil (SIH/SUS) 2010–2018 (SAEH) 2010–2017 to estimate admissions using ICD-10 codes, stratified by (0–4, 5–17, 18–49, 50–64, ≥65 years). Duration stay, admission intensive care unit (ICU),...

10.1371/journal.pone.0273837 article EN cc-by PLoS ONE 2022-11-10

•The burden of hospital-acquired influenza (HAI) is not fully understood.•Having an underlying disease important characteristic hospitalized ILI.•HAI occurred at a rate 1 in 13 with influenza-like-illness (ILI) hospital.•The incidence HAI was highest the geriatric ward and increased over time.•HAI rates approximate those reported for Clostridium difficile. BackgroundHospital-acquired potentially leads to significant morbidity mortality already vulnerable patients, but its overall understood....

10.1016/j.ajic.2020.12.003 article EN cc-by-nc-nd American Journal of Infection Control 2020-12-13

Influenza is a common respiratory virus which leads to over 400,000 annual deaths globally. Mortality from influenza highest among those aged 75 years and living in Africa Southeast Asia. To determine the burden of older adults presenting public hospitals with severe acute infection (SARI) during coronavirus disease 2019 (COVID-19) pandemic. This multi-center, prospective, observational study recruited individuals 65 who presented four Malaysian SARI 1 January 31 December 2021. Those prior...

10.3389/fmed.2022.977614 article EN cc-by Frontiers in Medicine 2022-10-10

Background and objectives While influenza circulates year-round in Malaysia, research data on its incidence is scarce. Yet, this information vital to the improvement of public health through evidence-based policies. In cross-sectional study, we aimed determine trends financial costs influenza. Methods Data for years 2016 2018 were gathered retrospectively from several sources. These existing Ministry Health (MOH) sentinel sites data, two teaching hospitals, private medical institutions Klang...

10.1371/journal.pone.0301068 article EN cc-by PLoS ONE 2024-03-22

Background: In this post hoc exploratory study of the APHP-COVIBOOST trial (NCT05124171), we used statistical modeling to describe evolution neutralizing antibody (nAb) titers over time, asses its impact on SARS-CoV-2 infection, and explore potential differences between three booster vaccine formulations (D614, B.1.351, BNT162b2). Methods: Antibody were measured for 208 adult participants at day 28, 3 months, 6 months using a microneutralization assay against different Omicron subvariants....

10.3390/vaccines12091079 article EN cc-by Vaccines 2024-09-21

Abstract Background: The Western Pacific Region (WPR) is exposed each year to seasonal influenza and often the source of new virus variants novel pathogen emergence. National surveillance systems play a critical role in detecting emerging viruses, monitoring epidemics, improving public disease awareness promoting pandemic preparedness, but vary widely across WPR countries. aim this study improve existing by systematically comparing selected systems. Methods: Three national with different...

10.21203/rs.3.rs-360363/v1 preprint EN cc-by Research Square (Research Square) 2021-04-07
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